メチルアデニン
English Journal
- Glucocorticoids: Dose-related effects on osteoclast formation and function via reactive oxygen species and autophagy.
- Shi J1, Wang L1, Zhang H1, Jie Q1, Li X1, Shi Q2, Huang Q1, Gao B1, Han Y1, Guo K1, Liu J3, Yang L4, Luo Z5.
- Bone.Bone.2015 Oct;79:222-32. doi: 10.1016/j.bone.2015.06.014. Epub 2015 Jun 24.
- Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of gl
- PMID 26115910
- A novel cognitive impairment mechanism that astrocytic p-connexin 43 promotes neuronic autophagy via activation of P2X7R and down-regulation of GLT-1 expression in the hippocampus following traumatic brain injury in rats.
- Sun L1, Gao J2, Zhao M2, Cui J3, Li Y1, Yang X1, Jing X4, Wu Z5.
- Behavioural brain research.Behav Brain Res.2015 Sep 15;291:315-24. doi: 10.1016/j.bbr.2015.05.049. Epub 2015 May 29.
- Connexin 43 (Cx43) is one of the major gap junction proteins in astrocytes. Our previous studies reported that astrocytic phosphorylated Cx43 (p-CX43) regulated neuronic autophagy levels in the rat hippocampus after traumatic brain injury (TBI). In this study, we explored the underlying molecular me
- PMID 26031379
- Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy.
- Yue HW1, Liu J1, Liu PP2, Li WJ1, Chang F1, Miao JY1, Zhao J3.
- Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep;1851(9):1186-93. doi: 10.1016/j.bbalip.2015.04.001. Epub 2015 Apr 12.
- Autophagy, evoked by diverse stresses including myocardial ischemia/reperfusion (I/R), profoundly affects the development of heart failure. However, the specific molecular basis of autophagy remains to be elucidated. Here we report that sphingosylphosphorylcholine (SPC), a bioactive sphingolipid, si
- PMID 25871970
Japanese Journal
- Intrathecal Injection of 3-Methyladenine Reduces Neuronal Damage and Promotes Functional Recovery via Autophagy Attenuation after Spinal Cord Ischemia/Reperfusion Injury in Rats
- Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells
Related Links
- 商品名 3-METHYLADENINE Isotope (METHYL-D3, 98%) 商品コード DLM-7471-50 Quantity 50 mg 価格(税抜), 円 Formula C6D3H4N5 Categories Research Products, RNA/DNA Products
- 3-Methyladenine is a selective autophagy and phosphoinositide 3-kinase (PI3K) inhibitor for Vps34 and PI3Kγ with IC50 of 25 and 60 nM, respectively. Find all the information about 3-Methyladenine for cell signaling research.
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- methyladenine, MeAde
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- メチルアミノプリン methylaminopurine