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any of the salts of hydrobromic acid; formerly used as a sedative but now generally replaced by safer drugs

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〈U〉臭化物(鎮静剤・睡眠剤として用いる) / 〈C〉《話》陳腐なことば

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/25 03:47:52」(JST)

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Methylscopolamine or methscopolamine, usually provided as the bromide salt (trade name Pamine), is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion.^[1] Proton pump inhibitors and antihistamine medications have made this use obsolete. It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications (trade names Extendryl, AlleRx, Rescon).

Methscopolamine, a methylated derivative of scopolamine, is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine. Its mechanism of action involves blocking the muscarinic acetylcholine receptors.

References

^ Drugs.com: Methscopolamine

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1. 物理的（誘発性）蕁麻疹 physical inducible forms of urticaria
2. 12歳未満の小児における慢性喘息：初回評価および診断 asthma in children younger than 12 years rescue treatment for acute symptoms
3. 小児における喘息の急性増悪：救急外来によるマネージメント acute asthma exacerbations in children emergency department management
4. 成人における亜急性および慢性咳嗽の治療 treatment of subacute and chronic cough in adults
5. 小児における喘息の急性増悪：入院患者のマネージメント acute asthma exacerbations in children inpatient management

English Journal

Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β(1-42).

Janíčková H, Rudajev V, Zimčík P, Jakubík J, Tanila H, El-Fakahany EE, Doležal V.SourceInstitute of Physiology CAS, Vídeňská 1083, 14220 Prague 4, Czech Republic. Electronic address: smyckova@biomed.cas.cz.
Neuropharmacology.Neuropharmacology.2012 Nov 30;67C:272-283. doi: 10.1016/j.neuropharm.2012.11.014. [Epub ahead of print]
The overproduction of β-amyloid (Aβ) fragments in transgenic APPswe/PS1dE9 mice results in formation of amyloid deposits in the cerebral cortex and hippocampus starting around four months of age and leading to cognitive impairment much later. We have previously found an age and transgene-dependen
PMID 23206502

Two seizure-onset types reveal specific patterns of high-frequency oscillations in a model of temporal lobe epilepsy.

Lévesque M, Salami P, Gotman J, Avoli M.SourceMontreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada H3A 2B4.
The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2012 Sep 19;32(38):13264-72.
High-frequency oscillations (HFOs; 80-500 Hz) are thought to mirror the pathophysiological changes occurring in epileptic brains. However, the distribution of HFOs during seizures remains undefined. Here, we recorded from the hippocampal CA3 subfield, subiculum, entorhinal cortex, and dentate gyrus
PMID 22993442

Japanese Journal

Crystal Structure of [7(S)-(1α, 2β, 4β, 5α, 7β]-7-(3-Hydroxy-1-oxo-2-phenylpropoxy)-9, 9-dimethyl-3-oxa-9-azoniatricyclo[3. 3. 1. 0^<2, 4>]nonane Bromide Monohydrate(Methscopolamine Bromide Monohydrate)

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 15(2), 203-204, 1999-02
NAID 10002418882

Effect of anticholinergic drugs on striatal acetylcholine release and motor activity in freely moving rats studied by brain microdialysis.

The Japanese Journal of Pharmacology 51(1), 75-82, 1989
NAID 130000832581

「メトスコポラミン」

Methylscopolamine bromide
Systematic (IUPAC) name
	(1R,2S,4R,5S,7R)-{[(2R)-3-hydroxy-2-phenylpropanoyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane
Clinical data
Trade names	Pamine, Extendryl, AlleRx, Rescon
AHFS/Drugs.com	monograph
MedlinePlus	a606008
Pharmacokinetic data
Biological half-life	3–4 hrs
Identifiers
CAS Number	155-41-9
ATC code	A03BB03 S01FA03
PubChem	CID 441342
DrugBank	DB00462
ChemSpider	21106347
UNII	RTN51LK7WL
ChEMBL	CHEMBL376897
Chemical data
Formula	C18H24NO4
Molar mass	318.388 g/mol
	SMILES OC[C@H](c1ccccc1)C(=O)O[C@H]2C[C@@H]3[N+](C)(C)[C@H](C2)[C@H]4O[C@@H]34 ;
	InChI InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/m1/s1 ; Key:LZCOQTDXKCNBEE-IKIFYQGPSA-N ;
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