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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/11 22:42:01」(JST)
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Methylscopolamine bromide
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| Systematic (IUPAC) name |
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(1R,2S,4R,5S,7R)-{[(2R)-3-hydroxy-2-phenylpropanoyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane
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| Clinical data |
| Trade names |
Pamine, Extendryl, AlleRx, Rescon |
| AHFS/Drugs.com |
monograph |
| MedlinePlus |
a606008 |
| Pharmacokinetic data |
| Biological half-life |
3–4 hrs |
| Identifiers |
| CAS Registry Number |
155-41-9 |
| ATC code |
A03BB03 S01FA03 |
| PubChem |
CID: 441342 |
| DrugBank |
DB00462 Y |
| ChemSpider |
21106347 Y |
| UNII |
RTN51LK7WL Y |
| ChEMBL |
CHEMBL376897 Y |
| Chemical data |
| Formula |
C18H24NO4 |
| Molecular mass |
318.388 g/mol |
SMILES
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OC[C@H](c1ccccc1)C(=O)O[C@H]2C[C@@H]3[N+](C)(C)[C@H](C2)[C@H]4O[C@@H]34
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InChI
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InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/m1/s1 Y
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Key:LZCOQTDXKCNBEE-IKIFYQGPSA-N Y
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| Y (what is this?) (verify) |
Methylscopolamine or methscopolamine, usually provided as the bromide salt (trade name Pamine), is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion.[1] Proton pump inhibitors and antihistamine medications have made this use obsolete. It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications (trade names Extendryl, AlleRx, Rescon).
Methscopolamine, a methylated derivative of scopolamine, is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine. Its mechanism of action involves blocking the muscarinic acetylcholine receptors.
References
- ^ Drugs.com: Methscopolamine
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This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (December 2009) |
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Drugs for functional gastrointestinal disorders (A03)
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Drugs for
functional
bowel disorders |
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Antimuscarinics
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Tertiary
amino group
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- Oxyphencyclimine
- Camylofin
- Mebeverine
- Trimebutine
- Rociverine
- Dicycloverine
- Dihexyverine
- Difemerine
- Piperidolate
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Quaternary
ammonium
compounds |
- Benzilone
- Mepenzolate
- Pipenzolate
- Glycopyrronium
- Oxyphenonium
- Penthienate
- Methantheline
- Propantheline
- Otilonium
- Tridihexethyl
- Isopropamide
- Hexocyclium
- Poldine
- Bevonium
- Diphemanil
- Tiemonium
- Prifinium
- Timepidium
- Fenpiverinium
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|
|
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Phosphodiesterase
inhibitors
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- Papaverine
- Drotaverine
- Moxaverine
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Acting on
serotonin receptors
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- 5-HT3 antagonists
- 5-HT4 agonists
- Mosapride
- Prucalopride
- Tegaserod
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Other
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- Alverine
- Caroverine
- Chlorbenzoxamine
- Diisopromine
- Dimethylaminopropionylphenothiazine
- Fenpiprane
- Fenoverine
- Idanpramine
- Isometheptene
- Phloroglucinol
- Pinaverium
- Proxazole
- Silicones
- Tiropramide
- Trepibutone
- Trimethyldiphenylpropylamine
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Belladonna
and derivatives
(antimuscarinics) |
- tertiary amines: Atropine
- Hyoscyamine
- quaternary ammonium compounds:
- Scopolamine
- Butylscopolamine
- Methylscopolamine
- Methylatropine
- Fentonium
- Cimetropium bromide
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| Propulsives |
- primarily dopamine antagonists
- Metoclopramide/Bromopride
- Clebopride
- Domperidone
- Alizapride
- 5-HT4 agonists
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Index of digestion
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| Description |
- Anatomy
- Physiology
- Development
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| Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
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| Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
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English Journal
- Regional quantification of muscarinic acetylcholine receptors and β-adrenoceptors in human airways.
- Ikeda T, Anisuzzaman AS, Yoshiki H, Sasaki M, Koshiji T, Uwada J, Nishimune A, Itoh H, Muramatsu I.SourceDivision of Thoracic Surgery, Department of Surgery, School of Medicine, University of Fukui, Eiheiji, Fukui, Japan.
- British journal of pharmacology.Br J Pharmacol.2012 Jul;166(6):1804-14. doi: 10.1111/j.1476-5381.2012.01881.x.
- BACKGROUND AND PURPOSE Muscarinic acetylcholine receptors (mAChRs) and β-adrenoceptors in the airways and lungs are clinically important in chronic obstructive pulmonary disease (COPD) and asthma. However, the quantitative and qualitative estimation of these receptors by radioligand binding approac
- PMID 22300233
- Reversal of scopolamine-induced disruption of prepulse inhibition by clozapine in mice.
- Singer P, Yee BK.SourceLaboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland. psinger@downeurobiology.org
- Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2012 Mar;101(1):107-14. Epub 2011 Dec 21.
- Prepulse inhibition (PPI) of the acoustic startle reflex refers to the reduction of the startle response to an intense acoustic pulse stimulus when it is shortly preceded by a weak non-startling prepulse stimulus and provides a cross-species measure of sensory-motor gating. PPI is typically impaired
- PMID 22210488
Japanese Journal
- Crystal Structure of [7(S)-(1α, 2β, 4β, 5α, 7β]-7-(3-Hydroxy-1-oxo-2-phenylpropoxy)-9, 9-dimethyl-3-oxa-9-azoniatricyclo[3. 3. 1. 0^<2, 4>]nonane Bromide Monohydrate(Methscopolamine Bromide Monohydrate)
- DEL CARMEN RAMIREZ-MEDELES Maria,SORIANO-GARCIA Manuel,AGUIRRE HERNANDEZ Gerardo,ORTEGA CHICOTE Fernando
- Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 15(2), 203-204, 1999-02
- NAID 10002418882
- GABA<SUB>A</SUB> and GABA<SUB>B</SUB>-Receptor Agonists Evoked Vagal Nerve Efferent Transmission in the Rat
- Yamasaki Katsuya,Goto Yoshiaki,Hara Nobuyuki,Hara Youichi
- The Japanese Journal of Pharmacology 55(1), 11-18, 1991
- … Methscopolamine (0.25mg/kg, i.v.) inhibited only the hyperacidity evoked by PCPGABA, but not vagal activation. …
- NAID 130000832987
Related Links
- Methscopolamine reduces the secretions of certain organs in the body, such as the stomach. ... Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow ...
- Methscopolamine official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. ... PHARMACOKINETICS Methscopolamine bromide is a quaternary ammonium ...
Related Pictures
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- 英
- methscopolamine
- 化
- 臭化メトスコポラミン methscopolamine bromide
抗コリン薬;鎮痙薬