関: methampicillin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/08 16:10:23」(JST)

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Metampicillin (INN) is a penicillin antibiotic. It is prepared by the reaction of ampicillin with formaldehyde, and is hydrolysed in aqueous solution with the formation of ampicillin. Hydrolysis is rapid under acid conditions, e.g., in the stomach, less rapid in neutral media, and incomplete in solutions such as human serum.^[1]

References

^ Sutherland R, Elson S, Croydon EA (1972). "Metampicillin. Antibacterial activity and absorption and excretion in man". Chemotherapy 17 (3): 145–60. doi:10.1159/000220849. PMID 4556172.

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English Journal

Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.

Luckner P, Brandsch M.SourceMembrane Transport Group, Biozentrum of the Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.Eur J Pharm Biopharm.2005 Jan;59(1):17-24.
The activity of the renal peptide transporters PEPT2 and PEPT1 determines-among other factors such as metabolic stability in liver and plasma-the circulatory half-life of penicillins and cephalosporins during therapy. This study was initiated to examine systematically the interaction of beta-lactam
PMID 15567297

Deacetoxycephalosporin C synthase isozymes exhibit diverse catalytic activity and substrate specificity.

Chin HS, Sim J, Seah KI, Sim TS.SourceDepartment of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, 117597, Singapore, Singapore.
FEMS microbiology letters.FEMS Microbiol Lett.2003 Jan 28;218(2):251-7.
The biosynthesis of cephalosporins involving a thiozolidine ring expansion is catalyzed by deacetoxycephalosporin C synthase (DAOCS). In this study, three DAOCS isozymes were cloned and expressed as active enzymes together with Streptomyces jumonjinensis DAOCS that was newly isolated and partially c
PMID 12586400

Japanese Journal

Simultaneous determination of ampicillin and metampicillin in biological fluids using high-performance liquid chromatography with column switching

LEE Heeyong,LEE Jung S.,LEE Hye S.
Journal of chromatography. B, Biomedical applications 664(2), 335-340, 1995-02-17
NAID 10024544235

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「methampicillin」

Metampicillin
Systematic (IUPAC) name
	3,3-Dimethyl-6-[[2-(methylideneamino)-2-phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Identifiers
CAS Number	6489-97-0
ATC code	J01CA14
PubChem	CID 4084
UNII	G0H6U7VSTK
ChEMBL	CHEMBL1908324
Chemical data
Formula	C17H19N3O4S
Molar mass	361.415 g/mol
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