メタクロマジー
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/29 18:49:54」(JST)
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Metachromasia (var. metachromasy) is a characteristic change in the color of staining carried out in biological tissues, exhibited by certain dyes when they bind to particular substances present in these tissues, called chromotropes. For example, toluidine blue becomes dark blue (with a colour range from blue-red dependant on glycoaminoglycan content) when bound to cartilage. The absence of color change in staining is named orthochromasia.
The underlying mechanism for metachromasia is the presence of polyanions within the tissue. When these tissues are stained with a concentrated basic dye solution, such as toluidine blue, the dye molecules are close enough to form dimeric and polymeric aggregates. The absorption properties of these aggregations differ from those of the individual nonaggregated dye molecules. Cell and tissue structures that have high concentrations of ionized sulfate and phosphate groups—such as the ground substance of cartilage, heparin-containing granules of mast cells, and rough endoplasmic reticulum of plasma cells—exhibit metachromasia. Therefore, toluidine blue will appear purple to red when it stains these components.
Although metachromasia was observed and described since 1875, by Cornil, Ranvier and others, it was the German scientist Paul Ehrlich (1854-1915) who gave its name and studied it more extensively. The modern understanding why metachromasy occurs was advanced by Belgian histologist Lucien Lison, who studied it between 1933 and 1936 and ascertained its value in the quantitative determination of sulfate esters of high molecular weight. He also studied the metachromasia of nucleic acids.
References
- Bergeron JA, Singer M. (1958) Metachromasy: An Experimental and Theoretical Reevaluation. J Cell Biol 4:433-457.
- Lison L, Mutsaars W. (1950) Metachromasy of nucleic acids. Quart. J. Microscop. Sci. 91: 309-314.
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English Journal
- Histochemical Study of Heparin-positive Mast Cells in the Terminal Part of Porcine Ductus Choledochus and Papilla Duodeni Major.
- Stefanov IS1, Vodenicharov AP2, Tsandev NS2, Sevrieva D3.
- Anatomia, histologia, embryologia.Anat Histol Embryol.2016 Oct;45(5):386-91. doi: 10.1111/ahe.12207. Epub 2015 Sep 22.
- The study presented in detail the localization and density of mast cells (MCs) in the intramural part of the common bile duct (CBD) and in the major duodenal papilla (MDP) of domestic swine. MCs' density (number/mm(2) ) in different layers of both of the duct and papilla was evaluated after toluidin
- PMID 26394797
- Mammary analogue secretory carcinoma of parotid: Is preoperative cytological diagnosis possible?
- Oza N1, Sanghvi K1, Shet T2, Patil A2, Menon S2, Ramadwar M2, Kane S2.
- Diagnostic cytopathology.Diagn Cytopathol.2016 Jun;44(6):519-25. doi: 10.1002/dc.23459. Epub 2016 Mar 4.
- Mammary analogue secretory carcinoma is a recently recognized tumor of salivary gland with characteristic t(12;15)(q13;q25) that results in ETV6-NTRK3 fusion product. Distinguishing mammary analogue secretory carcinoma from other salivary gland tumors is important. Present study highlights cytologic
- PMID 26945684
- Incidence of Mast Cells in Gingival and Periapical Inflammation- A Kaleidoscopic Study.
- Singh A1, Sreedhar G2, George J3.
- Journal of clinical and diagnostic research : JCDR.J Clin Diagn Res.2016 May;10(5):ZC06-8. doi: 10.7860/JCDR/2016/16136.7707. Epub 2016 May 1.
- INTRODUCTION: Mast cells are large granular cells that have classically been related to neutrophil stimulation during early step of inflammation.AIM: The objective of this work was to identify the incidence of mast cells in inflammatory lesions like periapical granuloma, pyogenic granuloma, gingival
- PMID 27437338
Japanese Journal
- 耳下腺に発生した myoepithelioma with lipomatous metaplasia の 1 例
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- metachromasia [met″ah-kro-ma´zhah] 1. failure to stain true with a given stain. 2. the different coloration of different tissues produced by the same stain. 3. change of color produced by staining. adj., adj metachromat´ic. met·a·chro ...
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