メプリン
- 関
- thiopronine、tiopronin
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/09/30 08:42:43」(JST)
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Meprin A |
Identifiers |
EC number |
3.4.24.18 |
CAS number |
148938-24-3 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
Meprin A (EC 3.4.24.18, endopeptidase-2, meprin-a, meprin, N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA-peptide hydrolase, PPH) is an enzyme that cleaves protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.[1]
Meprin A is a dimer composed of the products transcribed from the following two genes:
meprin A, alpha |
Identifiers |
Symbol |
MEP1A |
Entrez |
4224 |
HUGO |
7015 |
OMIM |
600388 |
RefSeq |
NM_005588 |
UniProt |
Q16819 |
Other data |
EC number |
3.4.24.18 |
Locus |
Chr. 6 p12-p11 |
|
meprin A, beta |
Identifiers |
Symbol |
MEP1B |
Entrez |
4225 |
HUGO |
7020 |
OMIM |
600389 |
RefSeq |
NM_005925 |
UniProt |
Q16820 |
Other data |
EC number |
3.4.24.18 |
Locus |
Chr. 18 q12.2-12.3 |
|
References
- ^ Sterchi EE, Stöcker W, Bond JS (October 2008). "Meprins, membrane-bound and secreted astacin metalloproteinases". Mol. Aspects Med. 29 (5): 309–28. doi:10.1016/j.mam.2008.08.002. PMC 2650038. PMID 18783725.
Proteases: metalloendopeptidases (EC 3.4.24)
|
|
ADAM proteins |
- Alpha secretases
- ADAM9
- ADAM10
- ADAM17
- ADAM19
- ADAM2
- ADAM7
- ADAM8
- ADAM11
- ADAM12
- ADAM15
- ADAM18
- ADAM22
- ADAM23
- ADAM28
- ADAM33
- ADAMTS1
- ADAMTS2
- ADAMTS3
- ADAMTS4
- ADAMTS5
- ADAMTS8
- ADAMTS9
- ADAMTS10
- ADAMTS12
- ADAMTS13
|
|
Matrix metalloproteinases |
- Collagenases
- Gelatinases
- MMP3
- MMP7
- MMP10
- MMP11
- MMP12
- MMP13
- MMP14
- MMP15
- MMP16
- MMP17
- MMP19
- MMP20
- MMP21
- MMP23A
- MMP23B
- MMP24
- MMP25
- MMP26
- MMP27
- MMP28
|
|
Other |
- Neprilysin
- Procollagen peptidase
- Thermolysin
- Pregnancy-associated plasma protein A
- Bone morphogenetic protein 1
- Lysostaphin
- Insulin-degrading enzyme
- ZMPSTE24
|
Enzymes
|
|
Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
|
Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
|
Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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|
Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
|
UpToDate Contents
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English Journal
- Identification and functional characterization of TNF receptor associated factor 3 in the sea cucumber Apostichopus japonicus.
- Yang L1, Chang Y2, Wang Y1, Wei J1, Ge C1, Song J1.
- Developmental and comparative immunology.Dev Comp Immunol.2016 Jun;59:128-35. doi: 10.1016/j.dci.2016.01.021. Epub 2016 Jan 30.
- TNF receptor associated factors (TRAFs) are a family of proteins primarily involved in both adaptive and innate immunity. In this study, we identified a novel TRAF3 gene in Apostichopus japonicus by transcriptome sequencing and RACE approaches (designated as AjTRAF3). The full-length of AjTRAF3 was
- PMID 26828393
- The anti-inflammatory peptide Ac-SDKP is released from thymosin β4 by renal meprin α and prolyl oligopeptidase.
- Kumar N1, Nakagawa P2, Janic B2, Romero CA2, Worou ME2, Monu SR2, Peterson EL1, Shaw J1, Valeriote F1, Ongeri EM3, Niyitegeka JV4, Rhaleb NE2, Carretero OA5.
- American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2016 Mar 9:ajprenal.00562.2015. doi: 10.1152/ajprenal.00562.2015. [Epub ahead of print]
- N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a natural tetra-peptide with anti-inflammatory and anti-fibrotic properties. We have previously shown that prolyl-oligopeptidase (POP) is involved in the Ac-SDKP release from thymosin β4 (Tβ4). However, POP can only hydrolyze peptides shorter than
- PMID 26962108
- Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage.
- Sato Y1, Kobayashi D1, Kohno T2, Kidani Y2, Prox J2, Becker-Pauly C3, Hattori M1.
- Journal of biochemistry.J Biochem.2016 Mar;159(3):305-12. doi: 10.1093/jb/mvv102. Epub 2015 Oct 21.
- Reelin is a secreted glycoprotein whose function is regulated by proteolysis. One of the specific cleavage sites of Reelin, called C-t, is located approximately between the sixth and seventh Reelin repeat but its exact site was unknown. We here show that a metalloprotease present in the culture supe
- PMID 26491063
Japanese Journal
- Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage
- 加齢にともなうⅢ型コラーゲン/Ⅰ型コラーゲンの比率の減少メカニズム:~Ⅲ型コラーゲンプロペプチド切断酵素meprinの加齢変化~
- 血清レクチンとメタロプロテアーゼとの相互作用のもつ生理的・病理的意義 (理工学部/工学部開設50周年記念号)
Related Links
- Whats The Definition Of Meprin? Dictionary.com Word FAQs Dictionary.com presents 366 FAQs, incorporating some of the frequently asked questions from the past with newer queries. Differences Etymology/Origins Spelling ...
- Thesaurus Legend: Synonyms Related Words Antonyms Noun 1. Meprin - a sedative and tranquilizer (trade name Miltown and Equanil and Meprin) used to treat muscle tension and anxiety Equanil, meprobamate, Miltown antianxiety ...
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