melanosomal

English Journal

Support and challenges to the melanosomal casing model based on nanoscale distribution of metals within iris melanosomes detected by X-ray fluorescence analysis.

Gorniak T1, Haraszti T, Suhonen H, Yang Y, Hedberg-Buenz A, Koehn D, Heine R, Grunze M, Rosenhahn A, Anderson MG.
Pigment cell & melanoma research.Pigment Cell Melanoma Res.2014 Sep;27(5):831-4. doi: 10.1111/pcmr.12278. Epub 2014 Jun 27.
Melanin within melanosomes exists as eumelanin or pheomelanin. Distributions of these melanins have been studied extensively within tissues, but less often within individual melanosomes. Here, we apply X-ray fluorescence analysis with synchrotron radiation to survey the nanoscale distribution of met
PMID 24903463

Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice.

Boross P1, Jansen JH1, van Tetering G1, Nederend M1, Brandsma A1, Meyer S1, Torfs E1, van den Ham HJ1, Meulenbroek L1, de Haij S1, Leusen JH2.
Immunology letters.Immunol Lett.2014 Aug;160(2):151-7. doi: 10.1016/j.imlet.2014.02.005. Epub 2014 Mar 5.
Patients suffering from advanced melanoma have a very poor prognosis. Despite recent advances in the understanding of oncogenic mechanisms and therapeutic interventions, the median survival of patients with metastatic disease is less than 12 months. Immunotherapy of melanoma has been intensely inves
PMID 24613852

McGlinchey RP1, Jiang Z, Lee JC.
Chembiochem : a European journal of chemical biology.Chembiochem.2014 Jul 21;15(11):1569-72. doi: 10.1002/cbic.201402074. Epub 2014 Jun 20.
Fibrils derived from Pmel17 are functional amyloids upon which melanin is deposited. Fibrils of the repeat domain (RPT) of Pmel17 form under strict melanosomal pH (4.5-5.5) and completely dissolve at pH≥6. To determine which Glu residue is responsible for this reversibility, aggregation of single,
PMID 24954152