meglumine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/25 12:30:58」(JST)

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Meglumine

Names
Systematic IUPAC name (2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentol
Other names Methylglucamine; N-Methylglucamine; 1-Deoxy-1-(methylamino)-D-glucitol; 1-Deoxy-1-methylaminosorbitol; N-Methylsorbitylamine; Meglumin
Identifiers
CAS Number	6284-40-8 Y
ChEBI	CHEBI:59732 N
ChEMBL	ChEMBL1200570 N
ChemSpider	8249 N
Jmol 3D model	Interactive image
PubChem	8567
UNII	6HG8UB2MUY N
InChI InChI=1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1 N Key: MBBZMMPHUWSWHV-BDVNFPICSA-N N
SMILES O[C@H]([C@@H](O)CNC)[C@H](O)[C@H](O)CO
Properties
Chemical formula	C7H17NO5
Molar mass	195.22 g·mol−1
Appearance	White crystals
log P	−2.509
Acidity (pKa)	9.52
Basicity (pKb)	0.526
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Meglumine is an amino sugar derived from sorbitol. It is often used as an excipient in pharmaceuticals and in conjunction with iodinated compounds in contrast media such as diatrizoate meglumine and iodipamide meglumine.

See also

• Flunixin meglumine
• Meglumine antimoniate

References

UpToDate Contents

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• 1. 皮膚リーシュマニア症の治療 treatment of cutaneous leishmaniasis
• 2. 造影剤に対する即時型過敏反応：再発反応の予防 immediate hypersensitivity reactions to radiocontrast media prevention of recurrent reactions
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• 4. 内臓リーシュマニア症の治療 treatment of visceral leishmaniasis
• 5. コントラスト心エコー検査：造影剤、安全性、およびイメージング技術 contrast echocardiography contrast agents safety and imaging technique

English Journal

• Preconditioning With Tauroursodeoxycholic Acid Protects Against Contrast-Induced HK-2 Cell Apoptosis by Inhibiting Endoplasmic Reticulum Stress.

• Peng P1, Ma Q1, Wang L1, Zhang O1, Han H1, Liu X1, Zhou Y2, Zhao Y1.
• Angiology.Angiology.2015 Nov;66(10):941-9. doi: 10.1177/0003319715575965. Epub 2015 Mar 29.
• To investigate whether tauroursodeoxycholic acid (TUDCA) could attenuate contrast media (CM)-induced renal tubular cell apoptosis by inhibiting endoplasmic reticulum stress (ERS), we exposed HK-2 cells to increasing doses of meglumine diatrizoate (20, 40, and 80 mg I/mL) for 2 to 16 hours, with/with
• PMID 25818106

• Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-Weighted Images After Gadobenate Dimeglumine Administration.

• Weberling LD1, Kieslich PJ, Kickingereder P, Wick W, Bendszus M, Schlemmer HP, Radbruch A.
• Investigative radiology.Invest Radiol.2015 Nov;50(11):743-8. doi: 10.1097/RLI.0000000000000206.
• OBJECTIVES: The aim of this study was to compare changes in signal intensity (SI) ratios of the dentate nucleus (DN) to pons and cerebrospinal fluid (CSF) on unenhanced T1-weighted magnetic resonance imaging (MRI) scans between the first and last MRI using the linear gadolinium-based contrast agent
• PMID 26352749

• Intestinal helminth coinfection is associated with mucosal lesions and poor response to therapy in American tegumentary leishmaniasis.

• de Azeredo-Coutinho RB1, Pimentel MI2, Zanini GM3, Madeira MF2, Cataldo JI2, de Oliveira Schubach A2, Quintella LP4, de Mello CX2, Mendonça SC5.
• Acta tropica.Acta Trop.2015 Oct 27. pii: S0001-706X(15)30138-8. doi: 10.1016/j.actatropica.2015.10.015. [Epub ahead of print]
• The most severe clinical form of American tegumentary leishmaniasis (ATL) due to Leishmania braziliensis is mucosal leishmaniasis (ML), characterized by destructive lesions in the facial mucosa. We performed a retrospective cohort study of 109 ATL patients from Rio de Janeiro State, Brazil, where AT
• PMID 26519200

Japanese Journal

• True Primary Enterolith Treated by Balloon-assisted Enteroscopy

• Internal Medicine 54(19), 2439-2442, 2015
• NAID 130005101818

• アントラサイクリンとホスアプレピタントメグルミン(プロイメンド)併用による投与静脈炎,静脈痛についての検討

• がん看護 19(1), 83-86, 2014-01
• NAID 40019949802

• Incidence and Severity of Acute Adverse Reactions to Four Different Gadolinium-based MR Contrast Agents

• Magnetic Resonance in Medical Sciences 13(1), 1-6, 2014
• NAID 130003392983

Related Links

• Meglumine | definition of meglumine by Medical dictionary

meg·lu·mine (meg'lū-mēn), USAN-approved contraction for N-methylglucamine. meglumine /meg·lu·mine/ (meg´loo-mēn) a crystalline base used in preparing salts of certain acids for use as a diagnostic radiopaque media, e.g., diatrizoate m., iothalamate m.

• Flunixin Meglumine - Banamine - Jump Start Recovery ...

Flunixin Meglumine Flunixin meglumine is a potent, non-narcotic, non-steroidal analgesic agent with anti-inflammatory and antipyretic activity. It is a potent inhibitor of the enzyme cyclooxygenase. It has demonstrated ...

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★リンクテーブル★

リンク元	「メグルミン」
拡張検索	「iothalamate meglumine」「meglumine gadopentetate」「meglumine sodium amidotrizoate」「meglumine sodium iodamide」「meglumine antimonate」

「メグルミン」

　　[★]

英

meglumine

ラ

megluminum

同

メチルグルカミン methylglucamine

商

アトルバスタチン、ウログラフイン、ガストログラフイン、ガドペンテト酸メグルミン、コンレイ、ビリスコピン、プロイメンド、マグネスコープ、マグネビスト

• X線造影剤に用いられる。有機ヨウ素化合物と結合する。イオトロクス酸メグルミン、メグルミンジアトリゾエート、メグルミンアイオディパミド、イオタラム酸メグルミンなど

参考

• wikipedia ja

http://ja.wikipedia.org/wiki/%E3%83%A1%E3%82%B0%E3%83%AB%E3%83%9F%E3%83%B3

「iothalamate meglumine」

　　[★]

イオタラム酸メグルミン、イオタラメートメグルミン、メグルミンイオタラメート

関

meglumine iotalamate

「meglumine gadopentetate」

　　[★]

ガドペンテト酸メグルミン

関

gadopentetate dimeglumine

「meglumine sodium amidotrizoate」

　　[★]

アミドトリゾ酸ナトリウムメグルミン

「meglumine sodium iodamide」

　　[★]

ヨーダミドナトリウムメグルミン

「meglumine antimonate」

　　[★] アンチモン酸メグルミン