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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/07 03:28:30」(JST)
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Medroxalol
|
Systematic (IUPAC) name |
5-(2-{[4-(1,3-Benzodioxol-5-yl)-2-butanyl]amino}-1-hydroxyethyl)-2-hydroxybenzamide |
Clinical data |
Identifiers |
CAS Registry Number
|
56290-94-9 |
PubChem |
CID 41835 |
ChemSpider |
38173 |
Chemical data |
Formula |
C20H24N2O5 |
Molecular mass
|
372.415 g/mol |
SMILES
- O=C(N)c1cc(ccc1O)C(O)CNC(C)CCc2ccc3OCOc3c2
|
InChI
-
InChI=1S/C20H24N2O5/c1-12(2-3-13-4-7-18-19(8-13)27-11-26-18)22-10-17(24)14-5-6-16(23)15(9-14)20(21)25/h4-9,12,17,22-24H,2-3,10-11H2,1H3,(H2,21,25)
Key:MPQWSYJGFLADEW-UHFFFAOYSA-N
|
Medroxalol is a vasodilator beta blocker also classified as a mixed receptor blocker as it blocks both alpha and beta receptors.
English Journal
- Beta-blocking agents with vasodilator activity.
- Rosendorff C.SourceDepartment of Medicine, Mt. Sinai School of Medicine, New York, New York.
- Journal of hypertension. Supplement : official journal of the International Society of Hypertension.J Hypertens Suppl.1993 Jun;11(4):S37-40.
- Use of non-selective beta-blockers: Non-selective beta-blockers reduce blood pressure by reducing cardiac output. They have a proven record of efficacy, alone or in combination with other drug classes, in the treatment of hypertension, ischemic heart disease and some tachyarrhythmias. They have also
- PMID 8104240
- An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists.
- van Zwieten PA.SourceDepartment of Pharmacotherapy, University of Amsterdam, The Netherlands.
- Drugs.Drugs.1993 Apr;45(4):509-17.
- Haemodynamically, the combination of alpha 1- and beta-adrenoceptor antagonists is a logical one. alpha 1-Adrenoceptor blockade causes vasodilatation and hence counteracts elevated peripheral vascular resistance, the most consistent haemodynamic derangement in established essential hypertension. bet
- PMID 7684671
Related Links
- Medroxalol. From Wikipedia, the free encyclopedia. Jump to: navigation, search ... Medroxalol is a vasodilator beta blocker also classified as a mixed receptor blocker as it blocks both alpha and beta receptors.
- Medroxalol, a new drug which has been reported to possess both alpha- and beta-adrenoceptor antagonist properties, was compared with labetalol in single dose studies in normotensive males. Oral doses of 400 mg of each drug significantly ...
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