メカセルミン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/05/28 18:04:18」(JST)
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Mecasermin
 | 
| Clinical data | 
| AHFS/Drugs.com | 
monograph | 
| Pregnancy cat. | 
C (US) | 
| Legal status | 
℞-only (US) | 
| Routes | 
Subcutaneous | 
| Identifiers | 
| CAS number | 
68562-41-4 N | 
| ATC code | 
H01AC03 | 
| DrugBank | 
DB01277 | 
| UNII | 
7GR9I2683O Y | 
| KEGG | 
D04870 N | 
| ChEMBL | 
CHEMBL1201716 N | 
| Chemical data | 
| Formula | 
C331H512N94O101S7 | 
| Mol. mass | 
7648.67 g/mol | 
 N (what is this?)  (verify)
  | 
Mecasermin (INN, brand name Increlex) is recombinant human insulin-like growth factor 1 (IGF-I) which is used for the long-term treatment of growth failure in children with severe primary IGF-I deficiency.[1][2]
This drug is not to be confused with mecasermin rinfabate (trade name: Iplex), which is the binary complex of recombinant human IGF-1 (rhIGF-1) and the binding protein that IGF-1 is naturally adhered to in the human body.
References [edit]
- ^ Fintini, D; Brufani, C; Cappa, M (2009). "Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency". Therapeutics and clinical risk management 5 (3): 553–9. PMC 2724186. PMID 19707272. 
 
- ^ "Increlex". Drugs.com. Retrieved 10 January 2010. 
 
 
| 
 Hypothalamic-pituitary hormones and analogues (H01) 
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| Hypothalamic | 
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 GNRH 
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- Agonists: Gonadorelin
 
- Nafarelin
 
- Histrelin
 
Antagonists: Cetrorelix 
- Ganirelix
 
 
 
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| 
 Somatostatin 
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- Agonists: Lanreotide
 
- Octreotide
 
- Pasireotide
 
- Vapreotide
 
 
 
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| Anterior pituitary | 
| 
 ACTH 
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- Agonists: Corticotropin
 
- Cosyntropin
 
- Tetracosactide
 
 
 
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| 
 GH 
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- Agonists: IGF-1 (Mecasermin/Mecasermin rinfabate)
 
- Sermorelin
 
- Somatrem
 
Antagonists: Pegvisomant 
 
 
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| 
 TSH 
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| Posterior pituitary | 
| 
 Oxytocin 
 | 
- Agonists: Carbetocin
 
- Demoxytocin
 
Antagonists: Atosiban 
 
 
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| 
 Vasopressin 
 | 
- Agonists: Argipressin
 
- Desmopressin
 
- Felypressin
 
- Lypressin
 
- Ornipressin
 
- Terlipressin
 
Antagonists: Conivaptan 
- Demeclocycline
 
- Lixivaptan
 
- Mozavaptan
 
- Nelivaptan
 
- Relcovaptan
 
- Satavaptan
 
- Tolvaptan
 
 
 
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| 
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noco (d)/cong/tumr, sysi/epon 
 
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proc, drug (A10/H1/H2/H3/H5) 
 
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UpToDate Contents
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English Journal
- Expression of Recombinant Human Insulin-like Growth Factor Type 1 (rhIGF-1) in Escherichia coli.
 
- Iranpoor H1, Omidinia E2, Vatankhah V3, Gharanjik V4, Shahbazi M5.
 
- Avicenna journal of medical biotechnology.Avicenna J Med Biotechnol.2015 Jul-Sep;7(3):101-5.
 
- BACKGROUND: Human insulin-like growth factor type 1 (hIGF-1) is a protein consisting of 70 amino acids (MW=7.6 kDa) and mainly synthesized by liver. Mecasermin (Trade name INCRELEX) is the synthetic form of the protein which is used as an effective treatment for particular disorders such as short st
 
- PMID 26306149
 
- Desensitization to mecasermin in an insulin-like growth factor 1-deficient patient.
 
- Gutiérrez-Fernández D1, Moreno-Ancillo Á2, Foncubierta-Fernández A3, López-Martínez I4, Lechuga-Sancho A4, Fernández-Anguita MJ5.
 
- Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.Ann Allergy Asthma Immunol.2015 Jun;114(6):523-5. doi: 10.1016/j.anai.2015.03.004. Epub  2015 Apr 3.
 
- PMID 25843163
 
- The insulin-like growth factor I system: physiological and pathophysiological implication in cardiovascular diseases associated with metabolic syndrome.
 
- Ren J1, Anversa P2.
 
- Biochemical pharmacology.Biochem Pharmacol.2015 Feb 15;93(4):409-17. doi: 10.1016/j.bcp.2014.12.006. Epub  2014 Dec 23.
 
- Metabolic syndrome is a cluster of risk factors including obesity, dyslipidemia, hypertension, and insulin resistance. A number of theories have been speculated for the pathogenesis of metabolic syndrome including impaired glucose and lipid metabolism, lipotoxicity, oxidative stress, interrupted neu
 
- PMID 25541285
 
Japanese Journal
- 545 組換えメカセルミン(IGF-I)の大量精製
 
- 544 大腸菌HB101によるメカセルミン(IGF-1)融合蛋白の高生産
 
- Large Scale Purification of Recombinant Insulin-Like Growth Factor I (IGF-I, Mecasermin) from a Fused Protein Produced in Escherichia coli
 
- Journal of fermentation and bioengineering 82(2), 134-139, 1996-08-25
 
- NAID 110002682339
 
Related Links
- Mecasermin is made by Tercica Pharmaceuticals (Increlex) as a treatment for 'short stature' due to severe primary IGF-1 deficiency (Primary IGFD) or with growth hormone (GH) gene deletion who have developed neutralizing antibodies ...
 
- Mecasermin can cause side effects that may impair thinking, reactions, or physical abilities. The child should avoid driving or doing anything else that requires alertness or coordination for the first 2 or 3 hours after a mecasermin ...
 
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