mean corpuscular hemoglobin concentration

関

hemoglobin, mean corpuscular concentration

WordNet

1. have a specified degree of importance; "My ex-husband means nothing to me"; "Happiness means everything"
2. an average of n numbers computed by adding some function of the numbers and dividing by some function of n (同)mean_value
3. mean or intend to express or convey; "You never understand what I mean!"; "what do his words intend?" (同)intend
4. denote or connote; "`maison means `house in French"; "An example sentence would show what this word means" (同)intend, signify, stand_for
5. (used of persons or behavior) characterized by or indicative of lack of generosity; "a mean person"; "he left a miserly tip" (同)mingy, miserly, tight
6. destine or designate for a certain purpose; "These flowers were meant for you"
7. excellent; "famous for a mean backhand"
8. the spatial property of being crowded together (同)density, denseness, tightness, compactness
9. bringing together military forces
10. strengthening the concentration (as of a solute in a mixture) by removing diluting material
11. the strength of a solution; number of molecules of a substance in a given volume
12. complete attention; intense mental effort (同)engrossment, absorption, immersion
13. increase in density
14. rich in significance or implication; "a meaning look" (同)pregnant, significant
15. the message that is intended or expressed or signified; "what is the meaning of this sentence"; "the significance of a red traffic light"; "the signification of Chinese characters"; "the import of his announcement was ambiguous" (同)significance, signification, import
16. the idea that is intended; "What is the meaning of this proverb?" (同)substance
17. considerable capital (wealth or income); "he is a man of means" (同)substance
18. how a result is obtained or an end is achieved; "a means of control"; "an example is the best agency of instruction"; "the true way to success" (同)agency, way
19. an instrumentality for accomplishing some end
20. a hemoprotein composed of globin and heme that gives red blood cells their characteristic color; function primarily to transport oxygen from the lungs to the body tissues; "fish have simpler hemoglobin than mammals" (同)haemoglobin, Hb

PrepTutorEJDIC

1. 〈人が〉…‘を'『意図する』,‘の'つもりである;…‘を'言おうとある;示そうとする / 〈単語・句・文章などが〉…‘を'『意味を持つ』,‘を'『意味する』 / (人に対して)…‘を'当てる,向ける《+『名』+『for』+『名』》 / 《受動態で》〈人・物〉‘を'(…)向きにする / 〈物事が〉…‘を'示す,表す / (結果として)〈物事が〉…‘を'もたらす,生じさせる / 《『mean』+『for』+『名』+『to』 do》《米話》(…が…するような)つもりでいる
2. 《名詞の前にのみ用いて》(品質・価値・才能などが)『劣った』,つまらない / (人・行為などが)『卑劣な』,さもしい / 《古》(身分・地位などが)卑しい / 《まれ》(身なり・建物などが)みずぼらしい,見るもあわれな / 《米話》(動物が)御しにくい;(一般に)扱いにくい
3. 中庸,中道 / (数学で) / 平均[値];(特に)算術平均,相加平均 / (比例式の)中項,内項 / (両極端の)中間の,中央に位置する / (大きさ・品質・程度などが)平均的な,平均の
4. 〈U〉(…への)(光線・注意などの)集中;(仕事などへの)専念,専心《+『on』+『名』》 / 〈C〉(人口などの)集中 / 〈U〉濃縮;〈液体の〉濃度
5. (・・・の)『目的』,意義《+『of』+『名』》 / (吾・文の)『意味』(sense)《+『of』+『名』》 / 意味ありげな様子,意味深長 / 《名詞の前にのみ用いて》意味ありげな,意味常長な / 《複合吾を作って》・・・するつもりの,の意図をもった
6. 〈C〉《単数・複数扱い》『方法』,『手段』 / 《複数扱い》『資力』,『財産』,富
7. ヘモグロビン,血色素

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/28 14:45:47」(JST)

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[Wiki en表示]

hemoglobin

The mean corpuscular hemoglobin concentration, a measure of the concentration of hemoglobin in a given volume of packed red blood cells. It is reported as part of a standard complete blood count.

It is calculated by dividing the hemoglobin by the hematocrit. Reference ranges for blood tests are 32 to 36 g/dl, or between 4.9 to 5.5 mmol/L. It is thus a mass or molar concentration. Still, many instances measure MCHC in percentage (%), as if it was a mass fraction (m_Hb / m_RBC). Numerically, however, the MCHC in g/dl and the mass fraction of hemoglobin in red blood cells in % are identical, assuming a RBC density of 1g/mL and negligible hemoglobin in plasma.

Interpretation

MCHC is diminished ("hypochromic") in microcytic anemias, and normal ("normochromic") in macrocytic anemias (due to larger cell size, though the hemoglobin amount or MCH is high, the concentration remains normal). MCHC is elevated ("hyperchromic") in hereditary spherocytosis, sickle cell disease and homozygous hemoglobin C disease.

This count is used to give a rough guide to what shade of red, RBC will be. (paler=lower than the standard)

Complications with cold agglutinin

Because of the way automated analysers count blood cells, a very high MCHC (greater than about 370 g/L) may indicate the blood is from someone with a cold agglutinin. This means that when their blood gets colder than 37°C it starts to clump together. As a result, the analyzer may incorrectly report a low number of very dense red blood cells for blood samples in which agglutination has occurred.

This problem is usually picked up by the laboratory before the result is reported. The blood is warmed until the cells separate from each other, and quickly put through the machine while still warm.This is the most sensitive test for iron deficiency anemia.

There are four steps to perform when an increase MCHC(>370 g/L or 37.0 g/dL) is received from the analyzer:

1. Remix the EDTA tube—if the MCHC corrects, report corrected results
2. Incubation at 37°C—if the MCHC corrects, report corrected results and comment on possible cold agglutinin
3. Saline replacement: Replace plasma with same amount of saline to exclude interference e.g. Lipemia and Auto-immune antibodies—if the MCHC corrects, report corrected results and comment on Lipemia
4. Check the slide for spherocytosis (e.g. in hereditary spherocytosis, among other causes)

Worked example

Measure	Units	Conventional units	Conversion
Hct	40%
Hb	100 grams/liter	10 grams/deciliter	(deci- is 10-1)
RBC	5E+12 cells/liter	5E+6 cells/μL	(micro is 10-6)
MCV = Hct / RBC	8E-14 liters/cell	80 femtoliters/cell	(femto- is 10-15)
MCH = Hb / RBC	2E-11 grams/cell	20 picograms/cell	(pico- is 10-12)
MCHC = MCH / MCV	250 grams/liter	25 grams/deciliter	(deci is 10-1)

See also

• Red blood cell indices
  • Mean corpuscular volume
  • Mean corpuscular hemoglobin

References

External links

• FP Notebook
• Cornell
• Medline

UpToDate Contents

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Related Pictures

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★リンクテーブル★

リンク元	「平均赤血球血色素濃度」「MCHC」
関連記事	「mean」「concentration」「means」「meaning」「corpuscular」

「平均赤血球血色素濃度」

　　[★]

英

mean corpuscular hemoglobin concentration, MCHC

同

平均赤血球ヘモグロビン濃度

関

MCV, MCH

意義

• 赤血球の中のヘモグロビン濃度
• 貧血の分類

• 正色素性
• 低色素性

定義

• 個々の赤血球のヘモグロビン濃度を％で表現した値 (LAB.275)

Hb(ヘモグロビン濃度[g/dl]) x 100 / Ht(ヘマトクリット値(%))

Htは0～100の場合。Htが比率の場合(0～1)は単に Hb/Ht

• 単位：% (次元は g/dl だが、定義上%となっている(流れがわかる　実践検査マニュアル 上巻 第1版第1刷 p.10)、LAB.275)

解釈

• 全血を適当な試薬で溶血させた後、ヘモグロビンを定量する。測定したヘモグロビン濃度は全血の体積に対する濃度であるが、赤血球全体の体積に対するヘモグロビン濃度に換算するためにヘマトクリット値で割る。100はパーセンテージを比に直すための数字。

基準値

• 31-35(g/dl) (2007前期生理学プリント)
• 33-36(%) (今日の診療プレミアムVol.17)
• 34±3(%) (異常の出るメカニズム第5版 p.76)
• 32-36(%) (LAB.275)

関連

• 赤血球、貧血

「MCHC」

　　[★] 平均赤血球血色素濃度 mean corpuscular hemoglobin concentration

「mean」

　　[★]

• n.

• 平均値、 手段

• adj.

• 平均の

• v.

(過去-過去分詞meant)

• 意味する

関

avenue、average、even、gateway、implication、imply、instrumental、mean value、meaning、means、policy、purport、represent、semantic、sense、tool

　 　 　 　 　 　 　 　 　 　

「concentration」

　　[★]

• n.

• 濃度、濃縮、(精神の)集中

関

attention、attentive、centralize、conc.、concentrate、concentrated、condensation、enrich、enrichment、focus

　 　 　 　 　 　 　

「means」

　　[★]

• np.

• 手段、方法

関

avenue、fashion、gateway、instrumental、manner、mean、method、mode、policy、procedure、process、tool、way

　 　 　 　

「meaning」

　　[★]

• n.

• 意味、意義

関

consequence、implication、imply、mean、purport、represent、semantic、sense、significance

　 　 　 　

「corpuscular」

　　[★]

• adj.

• 小体の

関

corpuscle