WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/08 13:35:39」(JST)

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Transcriptional regulation of tenascin-W by TGF-beta signaling in the bone metastatic niche of breast cancer cells.

Chiovaro F1,2, Martina E1,2, Bottos A1, Scherberich A3, Hynes NE1,2, Chiquet-Ehrismann R1,2.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Oct 15;137(8):1842-54. doi: 10.1002/ijc.29565. Epub 2015 Apr 29.
Tenascin-W is a matricellular protein with a dynamically changing expression pattern in development and disease. In adults, tenascin-W is mostly restricted to stem cell niches, and is also expressed in the stroma of solid cancers. Here, we analyzed its expression in the bone microenvironment of brea
PMID 25868708

Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukaemia.

Long X1, Yu Y1, Perlaky L1,2, Man TK1, Redell MS1,2.
British journal of haematology.Br J Haematol.2015 Sep;170(5):704-18. doi: 10.1111/bjh.13492. Epub 2015 May 14.
Approximately 50% of children with acute myeloid leukaemia (AML) relapse, despite aggressive chemotherapy. The bone marrow stromal environment protects leukaemia cells from chemotherapy (i.e., stroma-induced chemoresistance), eventually leading to recurrence. Our goal is to delineate the mechanisms
PMID 25974135

Molecular cloning and characterization of the matricellular protein Sparc/osteonectin in flatfish, Scophthalmus maximus, and its developmental stage-dependent transcriptional regulation during metamorphosis.

Torres-Núñez E1, Suarez-Bregua P1, Cal L1, Cal R2, Cerdá-Reverter JM3, Rotllant J4.
Gene.Gene.2015 Sep 1;568(2):129-39. doi: 10.1016/j.gene.2015.05.036. Epub 2015 May 15.
SPARC/osteonectin is a multifunctional matricellular glycoprotein, which is expressed in embryonic and adult tissues that undergo active proliferation and dynamic morphogenesis. Recent studies indicate that Sparc expression appears early in development, although its function and regulation during de
PMID 25981593

Maeda-Uematsu Aya,Kubota Satoshi,Kawaki Harumi,Kawata Kazumi,Miyake Yoshiaki,Hattori Takako,Nishida Takashi,Moritani Norifumi,Lyons Karen M.,Iida Seiji,Takigawa Masaharu
Journal of Cellular Biochemistry 115(5), 854-865, 2014-05
… CCN2/connective tissue growth factor (CTGF) is a unique molecule that promotes both chondrocytic differentiation and proliferation through its matricellular interaction with a number of extracellular biomolecules. … Up-regulation of a number of ribosomal protein genes was observed upon Ccn2 deletion, whereas a few genes required for aerobic and anaerobic ATP production were down-regulated in the Ccn2-null chondrocytes. …
NAID 120005468290

Circulating Thrombospondin-2 Reflects Disease Severity and Predicts Outcome of Heart Failure With Reduced Ejection Fraction

Hanatani Shinsuke,Izumiya Yasuhiro,Takashio Seiji [他]
Circulation journal : official journal of the Japanese Circulation Society 78(4), 903-910, 2014-04
NAID 40020023659