関: nordihydroguaiaretic acid

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/15 17:20:20」(JST)

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Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.

Mechanism[edit source | edit]

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.^[1]

References[edit source | edit]

^ "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". Am. J. Physiol. Endocrinol. Metab. 279 (3): E593–600. September 2000. PMID 10950827.

External links[edit source | edit]

MedlinePlus Drug Information
Actinex entry in the public domain NCI Cancer Dictionary

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

English Journal

Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin.

Yokoyama T1, Kosaka Y, Mizuguchi M.
Journal of medicinal chemistry.J Med Chem.2014 Nov 13;57(21):8928-35. doi: 10.1021/jm500997m. Epub 2014 Oct 20.
Transthyretin (TTR) is a homotetrameric serum protein associated with amyloidoses such as familial amyloid polyneuropathy and senile systemic amyloidosis. The amyloid fibril formation of TTR can be inhibited through stabilization of the TTR tetramer by the binding of small molecules. In this study,
PMID 25314129

Hepatocellular carcinoma targeting agents: conjugates of nitroimidazoles with trimethyl nordihydroguaiaretic acid.

Hsu MH1, Wu SC, Pao KC, Unlu I, Gnabre JN, Mold DE, Huang RC, Hwu JR.
ChemMedChem.ChemMedChem.2014 May;9(5):1030-7. doi: 10.1002/cmdc.201300521. Epub 2014 Mar 19.
Cancer has been a primary global health issue for decades, with hepatocellular carcinoma (HCC) resulting in more than half a million new cases annually. With survival rates as low as <5% after five years, it remains a poorly treated cancer. Nordihydroguaiaretic acid (NDGA), an antioxidant, was pr
PMID 24648164

A role for PacMYBA in ABA-regulated anthocyanin biosynthesis in red-colored sweet cherry cv. Hong Deng (Prunus avium L.).

Shen X1, Zhao K, Liu L, Zhang K, Yuan H, Liao X, Wang Q, Guo X, Li F, Li T.
Plant & cell physiology.Plant Cell Physiol.2014 May;55(5):862-80. doi: 10.1093/pcp/pcu013. Epub 2014 Jan 18.
The MYB transcription factors and plant hormone ABA have been suggested to play a role in fruit anthocyanin biosynthesis, but supporting genetic evidence has been lacking in sweet cherry. The present study describes the first functional characterization of an R2R3-MYB transcription factor, PacMYBA,
PMID 24443499

Japanese Journal

A double-blind vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck

OLSEN E. A.
J Am Acad Dermatol 24, 738-743, 1991
NAID 10007731607

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リンク元	「nordihydroguaiaretic acid」「マソプロコール」

「nordihydroguaiaretic acid」

Masoprocol
Systematic (IUPAC) name
	4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	B (US)
Legal status	?
Routes	Topical
Pharmacokinetic data
Bioavailability	Very low
Identifiers
CAS number	500-38-9
ATC code	L01XX10
PubChem	CID 71398
IUPHAR ligand	4265
DrugBank	DB00179
ChemSpider	64490
UNII	7BO8G1BYQU
ChEBI	CHEBI:73468
ChEMBL	CHEMBL313972
Chemical data
Formula	C18H22O4
Mol. mass	302.365 g/mol
	SMILES Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2;
	InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ ; Key:HCZKYJDFEPMADG-TXEJJXNPSA-N ;
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