マソプロコール
- 関
- nordihydroguaiaretic acid
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/09/15 17:20:20」(JST)
[Wiki en表示]
Masoprocol
|
Systematic (IUPAC) name |
4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol |
Clinical data |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Pregnancy cat. |
B (US) |
Legal status |
? |
Routes |
Topical |
Pharmacokinetic data |
Bioavailability |
Very low |
Identifiers |
CAS number |
500-38-9 Y |
ATC code |
L01XX10 |
PubChem |
CID 71398 |
IUPHAR ligand |
4265 |
DrugBank |
DB00179 |
ChemSpider |
64490 Y |
UNII |
7BO8G1BYQU Y |
ChEBI |
CHEBI:73468 N |
ChEMBL |
CHEMBL313972 N |
Chemical data |
Formula |
C18H22O4 |
Mol. mass |
302.365 g/mol |
SMILES
- Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2
|
InChI
-
InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ Y
Key:HCZKYJDFEPMADG-TXEJJXNPSA-N Y
|
N (what is this?) (verify)
|
Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.
Also called nordihydroguaiaretic acid, NDGA, and actinex.
Mechanism[edit source | edit]
Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.
It is a lipoxygenase inhibitor.[1]
References[edit source | edit]
- ^ "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". Am. J. Physiol. Endocrinol. Metab. 279 (3): E593–600. September 2000. PMID 10950827.
External links[edit source | edit]
- MedlinePlus Drug Information
- Actinex entry in the public domain NCI Cancer Dictionary
English Journal
- Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin.
- Yokoyama T1, Kosaka Y, Mizuguchi M.
- Journal of medicinal chemistry.J Med Chem.2014 Nov 13;57(21):8928-35. doi: 10.1021/jm500997m. Epub 2014 Oct 20.
- Transthyretin (TTR) is a homotetrameric serum protein associated with amyloidoses such as familial amyloid polyneuropathy and senile systemic amyloidosis. The amyloid fibril formation of TTR can be inhibited through stabilization of the TTR tetramer by the binding of small molecules. In this study,
- PMID 25314129
- Hepatocellular carcinoma targeting agents: conjugates of nitroimidazoles with trimethyl nordihydroguaiaretic acid.
- Hsu MH1, Wu SC, Pao KC, Unlu I, Gnabre JN, Mold DE, Huang RC, Hwu JR.
- ChemMedChem.ChemMedChem.2014 May;9(5):1030-7. doi: 10.1002/cmdc.201300521. Epub 2014 Mar 19.
- Cancer has been a primary global health issue for decades, with hepatocellular carcinoma (HCC) resulting in more than half a million new cases annually. With survival rates as low as <5% after five years, it remains a poorly treated cancer. Nordihydroguaiaretic acid (NDGA), an antioxidant, was pr
- PMID 24648164
- A role for PacMYBA in ABA-regulated anthocyanin biosynthesis in red-colored sweet cherry cv. Hong Deng (Prunus avium L.).
- Shen X1, Zhao K, Liu L, Zhang K, Yuan H, Liao X, Wang Q, Guo X, Li F, Li T.
- Plant & cell physiology.Plant Cell Physiol.2014 May;55(5):862-80. doi: 10.1093/pcp/pcu013. Epub 2014 Jan 18.
- The MYB transcription factors and plant hormone ABA have been suggested to play a role in fruit anthocyanin biosynthesis, but supporting genetic evidence has been lacking in sweet cherry. The present study describes the first functional characterization of an R2R3-MYB transcription factor, PacMYBA,
- PMID 24443499
Japanese Journal
- A double-blind vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck
Related Links
- Masoprocol - Get up-to-date information on Masoprocol side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Masoprocol ... Take masoprocol exactly as prescribed by your doctor. Follow the ...
- masoprocol (məsō´prəkol), n brand name: Actinex; drug class: antineoplastic (topical); action: inhibits lipoxygenase; use: actinic keratosis. ... Disclaimer All content on this website, including dictionary, thesaurus, literature ...
Related Pictures
![Masoprocol.svg](https://1mg.info/0/b/4/0676.jpg)
![Masoprocol skin cancer (actinic keratosis](https://1mg.info/0/b/4/0677.jpg)
![Masoprocol skin cancer (actinic keratosis](https://1mg.info/0/b/4/0678.jpg)
![Masoprocol - Wikipedia, the free](https://1mg.info/0/b/4/0679.jpg)
![kb masoprocol svg 10 kb 482 kb 581 kb 22](https://1mg.info/0/b/4/0680.jpg)
★リンクテーブル★
[★]
ノルジヒドログアヤレチン酸、ノルジヒドログアヤレチック酸
- 関
- masoprocol、NDGA
[★]
- 英
- masoprocol
- 関
- ノルジヒドログアヤレチン酸