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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/05 10:22:17」(JST)

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Beta-mannosidase (EC 3.2.1.25, mannanase, mannase, beta-D-mannosidase, beta-mannoside mannohydrolase, exo-beta-D-mannanase, lysosomal beta A mannosidase) is an enzyme with system name beta-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene.^[1]^[2]^[3]^[4]^[5]^[6] This enzyme catalyses the following chemical reaction

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides

This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.^[1]

References

^ ^a ^b "Entrez Gene: mannosidase".
^ Chen H, Leipprandt JR, Traviss CE, Sopher BL, Jones MZ, Cavanagh KT, Friderici KH (February 1995). "Molecular cloning and characterization of bovine beta-mannosidase". J. Biol. Chem. 270 (8): 3841–8. doi:10.1074/jbc.270.8.3841. PMID 7876128.
^ Adams, M., Richtmyer, N.K. and Hudson, C.S. (1943). "Some enzymes present in highly purified invertase preparations; a contribution to the study of fructofuranosidases, galactosidases, glucosidases and mannosidases". J. Am. Chem. Soc. 65 (7): 1369–1380. doi:10.1021/ja01247a029.
^ Bartholomew, B.A. and Perry, A.L. (1973). "The properties of synovial fluid β-mannosidase activity". Biochim. Biophys. Acta 315 (1): 123–127. doi:10.1016/0005-2744(73)90136-8. PMID 4743897.
^ Deuel, H., Lewuenberger, R. and Huber, G. (1950). "Über den enzymatischen Abbau von Carubin, dem Galaktomannan aus Ceratonia siliqua L". Helv. Chim. Acta 33 (4): 942–946. doi:10.1002/hlca.19500330424.
^ Hylin, J.W. and Sawai, K. (1964). "The enzymatic hydrolysis of Leucaena glauca galactomannan. Isolation of crystalline galactomannan depolymerase". J. Biol. Chem. 239: 990–992. PMID 14165949.

English Journal

Biochemical characterization of an acidophilic β-mannanase from Gloeophyllum trabeum CBS900.73 with significant transglycosylation activity and feed digesting ability.

Wang C1, Zhang J2, Wang Y1, Niu C1, Ma R3, Wang Y1, Bai Y1, Luo H4, Yao B5.
Food chemistry.Food Chem.2016 Apr 15;197(Pt A):474-81. doi: 10.1016/j.foodchem.2015.10.115. Epub 2015 Nov 10.
Acidophilic β-mannanases have been attracting much attention due to their excellent activity under extreme acidic conditions and significant industrial applications. In this study, a β-mannanase gene of glycoside hydrolase family 5, man5A, was cloned from Gloeophyllum trabeum CBS900.73, and succes
PMID 26616977

Metal-dependent thermal stability of recombinant endo-mannanase (ManB-1601) belonging to family GH 26 from Bacillus sp. CFR1601.

Srivastava PK1, Appu Rao G AR2, Kapoor M3.
Enzyme and microbial technology.Enzyme Microb Technol.2016 Mar;84:41-9. doi: 10.1016/j.enzmictec.2015.12.010. Epub 2015 Dec 24.
A GH 26 endo-mannanase from Bacillus sp. CFR1601 was purified to homogeneity (Mw ∼39kDa, specific activity 10,461.5±100IU/mg). Endo-mannanase gene (manb-1601, 1083bp, accession No. KM404299) was expressed in Escherichia coli BL21 (DE3) and showed typical fingerprints of α/β proteins in the far-
PMID 26827773

Structural, thermal and rheological characterization of modified Dalbergia sissoo gum-A medicinal gum.

Munir H1, Shahid M2, Anjum F3, Mudgil D4.
International journal of biological macromolecules.Int J Biol Macromol.2016 Mar;84:236-45. doi: 10.1016/j.ijbiomac.2015.12.001. Epub 2015 Dec 18.
Dalbergia sissoo gum was purified by ethanol precipitation. The purified gum was modified and hydrolyzed. Gum was modified by performing polyacrylamide grafting and carboxymethylation methods. The hydrolysis was carried out by using mannanase, barium hydroxide and trifluoroacetic acid. The modified
PMID 26709145

Japanese Journal

2P-052 放線菌マンナナーゼが示す分枝オリゴ糖に対する基質認識の分子機構(酵素学,酵素工学,一般講演)

日本生物工学会大会講演要旨集 66, 119, 2014-08-05
NAID 110009906436

A Novel β-1,4-mannanase Isolated from Paenibacillus polymyxa KT551

Food Science and Technology Research 20(6), 1261-1265, 2014
NAID 130004848143

Distribution of gastropods in a tidal flat in association with digestive enzyme activities

Plankton and Benthos Research 9(3), 156-167, 2014
NAID 130004688120

Related Pictures

★リンクテーブル★

リンク元	「マンナナーゼ」「マンナン加水分解酵素」

「マンナナーゼ」

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PMC	articles
PubMed	articles
NCBI	proteins

Beta-mannosidase
Identifiers
EC number	3.2.1.25
CAS number	9025-43-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search
PMC	articles
PubMed	articles
NCBI	proteins

Mannosidase, beta A, lysosomal
Identifiers
Symbols	MANBA ; MANB1
External IDs	OMIM: 609489 MGI: 88175 HomoloGene: 4317 ChEMBL: 3903 GeneCards: MANBA Gene
EC number	3.2.1.25
Gene ontology
Molecular function	• beta-mannosidase activity; • mannose binding;
Cellular component	• lysosome; • intracellular membrane-bounded organelle;
Biological process	• carbohydrate metabolic process; • cellular protein modification process; • mannan catabolic process;
	Sources: Amigo / QuickGO
Orthologs
	v; t; e;