- subject to a mathematical transformation
- change in outward structure or looks; "He transformed into a monster"; "The salesman metamorphosed into an ugly beetle" (同)transmute, metamorphose
- change or alter in form, appearance, or nature; "This experience transformed her completely"; "She transformed the clay into a beautiful sculpture"; "transubstantiate one element into another" (同)transmute, transubstantiate
- change (a bacterial cell) into a genetically distinct cell by the introduction of DNA from another cell of the same or closely related species
- convert (one form of energy) to another; "transform energy to light"
- increase or decrease (an alternating current or voltage)
- (mathematics) a function that changes the position or direction of the axes of a coordinate system
- the act of changing in form or shape or appearance; "a photograph is a translation of a scene onto a two-dimensional surface" (同)translation
- (genetics) modification of a cell or bacterium by the uptake and incorporation of exogenous DNA
- a qualitative change (同)transmutation, shift
- a rule describing the conversion of one syntactic structure into another related syntactic structure
- dangerous to health; characterized by progressive and uncontrolled growth (especially of a tumor)
- (別の形・外見・性質・状態などに)…‘を'『変える』,変化させる《+名+into+名》 / (物理・化学で)〈あるエネルギー〉‘を'他のエネルギーに変換する;〈電流〉‘を'変圧する
- 変形,変質;変身 / (物理学で)変換;(電流の)変圧 / (言吾学で)変形
- 悪意のある,敵意のある / (病気が)悪性の
Not to be confused with Transformation (genetics), the incorporation fo foreign DNA by bacteria.
||This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (November 2012)
Malignant transformation is the process by which cells acquire the properties of cancer. This may occur as a primary process in normal tissue, or secondarily as malignant degeneration of a previously existing benign tumor.
There are many causes of primary malignant transformation, or tumorigenesis. The underlying commonality is genetic mutation either by inheritance or more commonly by acquiring mutations in one's DNA over time. Although malignant transformation may occur because of changes within the cell, it can be induced by inorganic toxic substances such as cadmium or arsenite and organics such as tobacco-specific nitrosamines. It is also thought that some malignant transformations are due to viruses such as the Epstein-Barr virus, although this is currently restricted to just a few cancer types. A more common cancer associated with viral infection is cervical cancer, which has been linked to the human papilloma virus.
Malignant transformation of cells in a benign tumor may be detected by pathologic examination of tissues. Often the clinical signs and symptoms are suggestive of a malignant tumor. The physician, during the medical history examination, can find that there have been changes in size or patient sensation and, upon direct examination, that there has been a change in the lesion itself.
Risk assessments can be done and are known for certain types of benign tumor which are known to undergo malignant transformation. One of the better known examples of this phenomenon is the progression of a nevus to melanoma.
- Monti M (2000). L'ulcera cutanea: approccio multidisciplinare alla diagnosi ed al trattamento (in Italian). Milan: Springer. ISBN 978-88-470-0072-8.
- Francesco M (2001). Trattato di clinica e terapia chirurgica (in Italian). Padua: Piccin. ISBN 978-88-299-1566-8.
- Fishman JRA, Parker MG (1991). "Malignancy and chronic wounds: Marjolin's Ulcer". J. Burn Care Rehabil. 12 (3). PMID 1885637. [unreliable medical source?]
- Teratoma with malignant transformation
- Richter's transformation in blood cancers
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- 1. バレット食道：病因および癌化 barretts esophagus pathogenesis and malignant transformation
- 2. 初回治療後の精巣胚細胞腫瘍に対する外科的アプローチ approach to surgery following primary treatment for advanced testicular germ cell tumors
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- Why does cancer therapy lack effective anti-metastasis drugs?
- Weber GF.SourceUniversity of Cincinnati Academic Health Center, College of Pharmacy, Cincinnati, OH, USA. Electronic address: firstname.lastname@example.org.
- Cancer letters.Cancer Lett.2013 Jan 28;328(2):207-11. doi: 10.1016/j.canlet.2012.09.025. Epub 2012 Oct 8.
- The suppression of cancer metastasis is an urgent therapeutic need. Yet, most existing drugs inhibit only cancer cell proliferation. Historically, the reason is the much later elucidation of the molecular biology of metastasis versus that of the early steps in transformation. Because the molecules t
- PMID 23059758
- Epigenetic targeting therapies to overcome chemotherapy resistance.
- Balch C, Nephew KP.SourceMedical Sciences, Indiana University School of Medicine, Indiana University School of Medicine, Jordan Hall 300, 1001 East Third Street, Bloomington, IN 47405, USA. email@example.com
- Advances in experimental medicine and biology.Adv Exp Med Biol.2013;754:285-311. doi: 10.1007/978-1-4419-9967-2_14.
- It is now well established that epigenetic aberrations occur early in malignant transformation, raising the possibility of identifying chemopreventive compounds or reliable diagnostic screening using epigenetic biomarkers. Combinatorial therapies effective for the reexpression of tumor suppressors,
- PMID 22956507
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- malignant transformation the changes that a normal cell undergoes as it becomes a cancerous cell. See also carcinogenesis. malignant transformation The constellation of changes in the growth properties of cells in culture evoked ...
- Definition of malignant transformation in the Definitions.net dictionary. Meaning of malignant transformation. What does malignant transformation mean? Information and translations of malignant transformation in the most ...
- malignant transformation、oncogenic transformation、transform、oncogenic、canceration、cancerization
- conversion、convert、malignant transformation、oncogenic、oncogenic transformation、transformation、transforming、transgenic
- carcinogenesis、carcinogenetic、carcinogenic、carcinogenicity、malignant transformation、oncogenesis、oncogenic transformation、transform
- malignant transformation、malignant conversion
- malignant transformation、neoplastic transformation