同: 悪性転化

WordNet

subject to a mathematical transformation
change in outward structure or looks; "He transformed into a monster"; "The salesman metamorphosed into an ugly beetle" (同)transmute, metamorphose
change or alter in form, appearance, or nature; "This experience transformed her completely"; "She transformed the clay into a beautiful sculpture"; "transubstantiate one element into another" (同)transmute, transubstantiate
change (a bacterial cell) into a genetically distinct cell by the introduction of DNA from another cell of the same or closely related species
convert (one form of energy) to another; "transform energy to light"
increase or decrease (an alternating current or voltage)
(mathematics) a function that changes the position or direction of the axes of a coordinate system
the act of changing in form or shape or appearance; "a photograph is a translation of a scene onto a two-dimensional surface" (同)translation
(genetics) modification of a cell or bacterium by the uptake and incorporation of exogenous DNA
a qualitative change (同)transmutation, shift
a rule describing the conversion of one syntactic structure into another related syntactic structure
dangerous to health; characterized by progressive and uncontrolled growth (especially of a tumor)

PrepTutorEJDIC

(別の形・外見・性質・状態などに)…‘を'『変える』,変化させる《+名+into+名》 / (物理・化学で)〈あるエネルギー〉‘を'他のエネルギーに変換する;〈電流〉‘を'変圧する
変形,変質;変身 / (物理学で)変換;(電流の)変圧 / (言吾学で)変形
悪意のある,敵意のある / (病気が)悪性の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/27 14:56:10」(JST)

wiki en

[Wiki en表示]

Not to be confused with Transformation (genetics), the incorporation fo foreign DNA by bacteria.

Malignant transformation is the process by which cells acquire the properties of cancer. This may occur as a primary process in normal tissue, or secondarily as malignant degeneration of a previously existing benign tumor.

There are many causes of primary malignant transformation, or tumorigenesis. The underlying commonality is genetic mutation either by inheritance or more commonly by acquiring mutations in one's DNA over time. Although malignant transformation may occur because of changes within the cell, it can be induced by inorganic toxic substances such as cadmium or arsenite and organics such as tobacco-specific nitrosamines. It is also thought that some malignant transformations are due to viruses such as the Epstein-Barr virus, although this is currently restricted to just a few cancer types. A more common cancer associated with viral infection is cervical cancer, which has been linked to the human papilloma virus.

Malignant transformation of cells in a benign tumor may be detected by pathologic examination of tissues. Often the clinical signs and symptoms are suggestive of a malignant tumor. The physician, during the medical history examination, can find that there have been changes in size or patient sensation and, upon direct examination, that there has been a change in the lesion itself.

Risk assessments can be done and are known for certain types of benign tumor which are known to undergo malignant transformation. One of the better known examples of this phenomenon is the progression of a nevus to melanoma.

References[edit]

Monti M (2000). L'ulcera cutanea: approccio multidisciplinare alla diagnosi ed al trattamento (in Italian). Milan: Springer. ISBN 978-88-470-0072-8.
Francesco M (2001). Trattato di clinica e terapia chirurgica (in Italian). Padua: Piccin. ISBN 978-88-299-1566-8.
Fishman JRA, Parker MG (1991). "Malignancy and chronic wounds: Marjolin's Ulcer". J. Burn Care Rehabil. 12 (3). PMID 1885637. ^{[unreliable medical source?]}

UpToDate Contents

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1. バレット食道：病因および癌化 barretts esophagus pathogenesis and malignant transformation
2. 初回治療後の精巣胚細胞腫瘍に対する外科的アプローチ approach to surgery following primary treatment for advanced testicular germ cell tumors
3. 縦隔および後腹膜を含む性腺外胚細胞腫瘍 extragonadal germ cell tumors involving the mediastinum and retroperitoneum
4. 汗孔角化症 porokeratosis
5. 肝腺腫 hepatic adenoma

English Journal

Why does cancer therapy lack effective anti-metastasis drugs?

Weber GF.SourceUniversity of Cincinnati Academic Health Center, College of Pharmacy, Cincinnati, OH, USA. Electronic address: georg.weber@uc.edu.
Cancer letters.Cancer Lett.2013 Jan 28;328(2):207-11. doi: 10.1016/j.canlet.2012.09.025. Epub 2012 Oct 8.
The suppression of cancer metastasis is an urgent therapeutic need. Yet, most existing drugs inhibit only cancer cell proliferation. Historically, the reason is the much later elucidation of the molecular biology of metastasis versus that of the early steps in transformation. Because the molecules t
PMID 23059758

Epigenetic targeting therapies to overcome chemotherapy resistance.

Balch C, Nephew KP.SourceMedical Sciences, Indiana University School of Medicine, Indiana University School of Medicine, Jordan Hall 300, 1001 East Third Street, Bloomington, IN 47405, USA. rbalch@indiana.edu
Advances in experimental medicine and biology.Adv Exp Med Biol.2013;754:285-311. doi: 10.1007/978-1-4419-9967-2_14.
It is now well established that epigenetic aberrations occur early in malignant transformation, raising the possibility of identifying chemopreventive compounds or reliable diagnostic screening using epigenetic biomarkers. Combinatorial therapies effective for the reexpression of tumor suppressors,
PMID 22956507

Japanese Journal

症例報告成熟囊胞性奇形腫の悪性転化と鑑別を必要とした子宮脂肪平滑筋腫の1例

東京産科婦人科学会会誌 64(3), 489-493, 2015-07
NAID 40020577332

症例報告悪性転化を来した線維性骨異形成の1例

臨床整形外科 50(7), 693-697, 2015-07
NAID 40020514973

ヒト口腔扁平上皮癌におけるStreptococcus anginosus感染とactivation-induced cytidine deaminase (AID)異所性発現

岩手医科大学歯学雑誌 40(1), 26-37, 2015-04-23
NAID 110009936933

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