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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/15 07:42:56」(JST)

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Malakoplakia is a rare inflammatory condition which makes its presence known as a papule, plaque^{[disambiguation needed]} or ulceration that usually affects the genitourinary tract.^[1]^:274 However, it may also be associated with other bodily organs. It was initially described in the early 1900s as soft yellowish plaques found on the mucosa of the urinary bladder. Microscopically it is characterized by the presence of foamy histiocytes with basophilic inclusions called Michaelis-Gutmann bodies.

It usually involves gram negative bacteria.^[2]

Causes

Malakoplakia is thought to result from the insufficient killing of bacteria by macrophages. Therefore, the partially digested bacteria accumulate in macrophages and leads to a deposition of iron and calcium. The impairment of bactericidal activity manifests itself as the formation of an ulcer, plaque or papule.

Malakoplakia is associated with patients with a history of immunosuppression due to lymphoma, diabetes mellitus, renal transplantation, or because of long-term therapy with systemic corticosteroids.

Treatment

Today, antibiotics are used for treatment of malakoplakia.

References

^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
^ Liang Cheng; David G. Bostwick (2006). Essentials of anatomic pathology. Springer. pp. 1180–. ISBN 978-1-58829-461-6. Retrieved 15 May 2010.

UpToDate Contents

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1. ロドコッカス・エクイ感染症の微生物学、病因、および疫学 microbiology pathogenesis and epidemiology of rhodococcus equi infections
2. 黄色肉芽腫性腎盂腎炎 xanthogranulomatous pyelonephritis
3. 腎および腎周囲膿瘍 renal and perinephric abscess
4. 成人における皮膚筋炎および多発性筋炎の診断および鑑別診断 diagnosis and differential diagnosis of dermatomyositis and polymyositis in adults
5. 成人における皮膚筋炎および多発性筋炎の臨床症状 clinical manifestations of dermatomyositis and polymyositis in adults

English Journal

Quiz page January 2014: Cachexia, urinary tract infection, nephromegaly, and kidney failure.

Storm A1, Bhasin B2, Rangachari D3, Sperati CJ2.
American journal of kidney diseases : the official journal of the National Kidney Foundation.Am J Kidney Dis.2014 Jan;63(1):A18-21. doi: 10.1053/j.ajkd.2013.07.027.
PMID 24360229

Successful treatment of malakoplakia of the bladder in a kitten.

Rutland BE1, Nimmo J, Goldsworthy M, Simcock JO, Simpson KW, Kuntz CA.
Journal of feline medicine and surgery.J Feline Med Surg.2013 Aug;15(8):744-8. doi: 10.1177/1098612X12471663. Epub 2013 Jan 8.
A 4-month-old female kitten presented with chronic lower urinary tract signs and Escherichia coli cystitis, and was diagnosed with urinary bladder malakoplakia based upon histopathology. The kitten was treated with a prolonged antibiotic course and the malakoplakia resolved. Malakoplakia is a chroni
PMID 23300187

Malakoplakia in a healthy young female patient.

Hyun KH1, Shin HD, Kim DH.
The Korean journal of internal medicine.Korean J Intern Med.2013 Jul;28(4):475-80. doi: 10.3904/kjim.2013.28.4.475. Epub 2013 Jul 1.
Malakoplakia is a rare granulomatous disease that occurs commonly in the urinary tract and secondarily in the gastrointestinal tract. Most reported cases of malakoplakia are associated with immunosuppressive diseases or chronic prolonged illness. Here, we report a rare case of malakoplakia in a youn
PMID 23864806

Japanese Journal

嚢胞性腎細胞癌との鑑別が困難であった腎マラコプラキアの1例

日向泰樹,中村成伸,石野外志勝 [他],川上一雄
日本泌尿器科學會雜誌 102(3), 591-594, 2011-05-20
患者は66歳,男性.糖尿病にてインスリン療法中であった.2009年10月24日右腹部腫瘤,右腰部痛を主訴に当院受診,腹部造影CTにて右腎下極に122×90×87mm大の多房性嚢胞性腫瘤を認め,疼痛管理,加療目的にて入院となった.腫瘤は腸腰筋,上行結腸,十二指腸など広範囲に癒着,浸潤が疑われた.CTでの嚢胞内のdensityの上昇,炎症反応高値,発熱を認め,嚢胞性腎細胞癌の感染が考えられたが,広範囲 …
NAID 110008661932

保存的治療にて軽快した腎マラコプラキアの1例

田口功,寺川智章,常森寛行 [他],今西治,山中望,近藤武史,伊藤利江子
日本泌尿器科學會雜誌 98(7), 839-842, 2007-11-20
症例は69歳女性.左腎腫瘤を指摘され当科受診した.腹部CTでは左腎上極に内部が不均一に造影される50mm大の腫瘤を認めた.画像検査からは原発性腎悪性腫瘍を疑ったが,病歴および腫瘍マーカーからは転移性腫瘍の可能性も否定できず,経皮的CTガイド下針生検を行った.生検組織標本は炎症性肉芽腫の像であった,一部の組織球の細胞質内にMichaelis-Gutmann小体を認め,腎実質性マラコプラキアの診断に至 …
NAID 110006531495

Related Pictures

★リンクテーブル★

リンク元	「マラコプラキア」「plakia」「malakoplakia」
拡張検索	「vesical malacoplakia」

「マラコプラキア」

Malakoplakia
	Classification and external resources
	; Micrograph showing the characteristic finding of malakoplakia (Michaelis-Gutmann bodies). H&E stain.
DiseasesDB	29128
eMedicine	derm/872
MeSH	D008287

　　[★]

英: malacoplakia、malakoplakia
同: 軟斑性膀胱カタル
関: 膀胱マラコプラキア vesical malacoplakia

「plakia」

　　[★]

suffix meaning "a plate or flat plane, usually on a mucous membrane"

ex.

leukoplakia
malacoplakia
melanoplakia

「malakoplakia」

　　[★]

マラコプラキア

関: malacoplakia

「vesical malacoplakia」

　　[★] 膀胱マラコプラキア

[Andrews-1] James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

[ChengBostwick2006-2] Liang Cheng; David G. Bostwick (2006). Essentials of anatomic pathology. Springer. pp. 1180–. ISBN 978-1-58829-461-6. Retrieved 15 May 2010.

匿名

検索

案内

案内

malacoplakia