メッセンジャーRNP
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/25 15:16:35」(JST)
[Wiki en表示]
Messenger RNP (messenger ribonucleoprotein) is mRNA with bound proteins. mRNA does not exist in vivo "naked", mRNA is always bound by many different proteins while being synthesized, spliced, exported and while being translated in the cytoplasm.[1] [2]
When mRNA is being synthesized by RNA polymerase, this nascent mRNA is already bound by RNA 5′ end 7-methyl-guanosine capping enzymes. Later mRNA is bound by exon and intron definition complexes, and splicing snRNPs. The spliced mRNA is bound the other set of proteins which help in export from the nucleus to the cytoplasm. In vertebrates exon-exon junction are marked by exon junction complexes which in the cytosol could trigger nonsense mediated decay if the exon-exon junction is downstream of the stop codon.
See also
- Precursor mRNA
- Messenger RNA
- Heterogeneous ribonucleoprotein particle
References
- ^ Hieronymus, Haley; Pamela A. Silver (2004-12-01). "A systems view of mRNP biology". Genes & Development 18 (23): 2845–2860. doi:10.1101/gad.1256904. ISSN 0890-9369. Retrieved 2013-07-24.
- ^ Bergkessel, Megan; Gwendolyn M. Wilmes; Christine Guthrie (2009-02-20). "SnapShot: Formation of mRNPs". Cell 136 (4): 794–794.e1. doi:10.1016/j.cell.2009.01.047. ISSN 0092-8674. Retrieved 2013-07-24.
English Journal
- The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export.
- Kristó I1, Bajusz C1, Borsos BN2, Pankotai T2, Dopie J3, Jankovics F1, Vartiainen MK3, Erdélyi M1, Vilmos P4.
- Biochimica et biophysica acta.Biochim Biophys Acta.2017 Oct;1864(10):1589-1604. doi: 10.1016/j.bbamcr.2017.05.020. Epub 2017 May 27.
- PMID 28554770
- Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning.
- Escobar-Aguirre M1, Zhang H1, Jamieson-Lucy A1, Mullins MC1.
- PLoS genetics.PLoS Genet.2017 Sep 7;13(9):e1006983. doi: 10.1371/journal.pgen.1006983. [Epub ahead of print]
- PMID 28880872
- Nup42 and IP6 coordinate Gle1 stimulation of Dbp5/DDX19B for mRNA export in yeast and human cells.
- Adams RL1, Mason AC1, Glass L1, Aditi1, Wente SR1.
- Traffic (Copenhagen, Denmark).Traffic.2017 Sep 4. doi: 10.1111/tra.12526. [Epub ahead of print]
- PMID 28869701
Japanese Journal
- Importance of glucose-6-phosphate dehydrogenase (G6PDH) for vanillin tolerance in Saccharomyces cerevisiae(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- リグノセルロース系バイオマス由来発酵阻害剤による酵母の翻訳阻害とmRNP顆粒の形成
- バイオサイエンスとインダストリー = Bioscience & industry 71(5), 416-419, 2013-09-01
- NAID 10031192973
- 4Dp18 発酵阻害物質フルフラールおよびHMFによるmRNP granuleの形成誘導(発酵生理学,発酵工学,一般講演)
Related Links
- メッセンジャーRNA (mRNA) は細胞の中では常に、特定の蛋白質との複合体である メッセンジャーRNP (mRNP, messenger ribonucleoprotein) として存在しています。それぞれのmRNAの安定性や翻訳活性の調節といった運命は、どのような ...
- [研究課題名] mRNPの細胞内動態と活性調節 [研究課題名(英文)] Regulation of mRNP [研究担当者(分担者も含む)]松本 健 [研究室] 辻本細胞生化学研究室 1. 研究目的(500字程度) 高等真核細胞の遺伝子発現においてはDNAの ...
Related Pictures
★リンクテーブル★
[★]
- 同
- mRNP
- 関
- リボ核蛋白質
[★]
- 英
- pre-mRNP
- 同
- プレメッセンジャーRNP pre-messenger RNP mRNP前駆体
- 関
- プレmRNA