リゾホスファチジルセリン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/16 00:35:26」(JST)
[Wiki en表示]
Lysophosphatidylserine is a lysophospholipid which triggers TLR 2.
A recent study showed that it does not stimulate normal leukocytes.[1] It also enhances glucose transport, lowering blood glucose levels while leaving secretion of insulin unaffected.[2]
References
- ^ Park KS, Lee HY, Kim MK, Shin EH, Bae YS (Jul 2005). "Lysophosphatidylserine stimulates leukemic cells but not normal leukocytes". Biochemical and Biophysical Research Communications. 333 (2): 353–8. doi:10.1016/j.bbrc.2005.05.109. PMID 15946646.
- ^ Yea K, Kim J, Lim S, Kwon T, Park HS, Park KS, Suh PG, Ryu SH (Jan 2009). "Lysophosphatidylserine regulates blood glucose by enhancing glucose transport in myotubes and adipocytes". Biochemical and Biophysical Research Communications. 378 (4): 783–8. doi:10.1016/j.bbrc.2008.11.122. PMID 19063864.
External links
- Lysophosphatidylserine at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity.
- Fairn GD, Hermansson M, Somerharju P, Grinstein S.SourceProgram in Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
- Nature cell biology.Nat Cell Biol.2011 Oct 2. doi: 10.1038/ncb2351. [Epub ahead of print]
- Polarity is key to the function of eukaryotic cells. On the establishment of a polarity axis, cells can vectorially target secretion, generating an asymmetric distribution of plasma membrane proteins. From Saccharomyces cerevisiae to mammals, the small GTPase Cdc42 is a pivotal regulator of polarity
- PMID 21964439
- Systems wide analyses of lipids in the brainstem during inflammatory orofacial pain - Evidence of increased phospholipase A(2) activity.
- Ma MT, Yeo JF, Shui G, Wenk MR, Ong WY.SourceDepartment of Oral and Maxillofacial Surgery, National University of Singapore, Singapore.
- European journal of pain (London, England).Eur J Pain.2011 Jul 21. [Epub ahead of print]
- Recent studies suggest that CNS phospholipase A(2) (PLA(2)) isoforms play a role in nociception, but until now, direct evidence of increased brain PLA(2) activity during allodynia or hyperalgesia is lacking. The present study was carried out, using lipidomics or systems wide analyses of lipids using
- PMID 21783394
Japanese Journal
- 新しいリゾリン脂質メディエーターリゾホスファチジルセリン (特集 リン脂質代謝と脂質メディエーター研究の最新の成果) -- (リゾリン脂質を中心とした脂質メディエーター)
- Identification of Lipid Inhibitor of Mammalian Phospholipase D^1
- KAWABE Koichi,KODAKI Tsutomu,KATAYAMA Kazuhisa,OKAMURA Shin-ichi,MORI Masatomo,YAMASHITA Satoshi
- The journal of biochemistry 123(5), 870-875, 1998-05-01
- NAID 10005844857
Related Links
- Looking for online definition of lysophosphatidylserine in the Medical Dictionary? lysophosphatidylserine explanation free. What is lysophosphatidylserine? Meaning of lysophosphatidylserine medical term. What does Search / ? ...
- It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G-protein-coupled receptors. N ... Other LPLs include lysophosphatidylglycerol (LPG ...
Related Pictures
![controls brain lysophosphatidylserine](https://1mg.info/0/7/7/0766.jpg)
![binding to lysophosphatidylserine molecule](https://1mg.info/0/7/7/0767.jpg)
![controls brain lysophosphatidylserine](https://1mg.info/0/7/7/0768.jpg)
![controls brain lysophosphatidylserine](https://1mg.info/0/7/7/0769.jpg)
![formula of lysophosphatidylserine](https://1mg.info/0/7/7/0770.jpg)
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