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Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/09/02 01:03:21」(JST)
[Wiki en表示]
chemokine (C motif) ligand 1, lymphotactin |
Identifiers |
Symbol |
XCL1 |
Alt. symbols |
SCYC1, LTN, LPTN, ATAC, SCM-1a, SCM-1 |
Entrez |
6375 |
HUGO |
10645 |
OMIM |
600250 |
RefSeq |
NM_002995 |
UniProt |
P47992 |
Other data |
Locus |
Chr. 1 q24.2 |
Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells.[1][2] This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose gene is found at the same locus on chromosome 1.[2] XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.[3]
Lymphotactin, LTN, is found in two states: a monomer at 10°C, LTN10, and a dimer at 40°C, LTN40.[4]
References[edit source | edit]
- ^ Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol 155 (1): 203–9. PMID 7602097.
- ^ a b Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett 395 (1): 82–8. doi:10.1016/0014-5793(96)01004-6. PMID 8849694.
- ^ Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.
- ^ Tyler, Robert C.; Tyler, R. C.; Murray, N. J. ; Peterson, F. C.; Volkman, B. F. (2011). "Native state interconversion of a metamorphic protein requires global unfolding". Biochemistry 50 (33): 7077–9. doi:10.1021/bi200750k. PMC 3160782. PMID 21776971.
Cell signaling: cytokines
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By family |
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By function/
cell |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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English Journal
- The prognostic significance of serum XCL1 concentration in patients with acute lymphoblastic leukemia: a pilot study.
- Gutiérrez-Aguirre CH1, Flores-Jiménez JA2, Alatorre-Ricardo J2, Cantú-Rodríguez OG2, Rosas-Taraco A3, Salazar-Riojas R2, Jaime-Pérez JC2, Sánchez-Cárdenas M2, López-Silva L2, Martínez-Castilla AM3, Salinas-Carmona MC3, Gómez-Almaguer D2.
- Annals of hematology.Ann Hematol.2017 Dec;96(12):2015-2024. doi: 10.1007/s00277-017-3142-3. Epub 2017 Oct 13.
- PMID 29027574
- A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.
- Matsumoto N1, Kon S2,3, Nakatsuru T1, Miyashita T1, Inui K1, Saitoh K1, Kitai Y1, Muromoto R1, Kashiwakura JI1, Uede T4, Matsuda T1.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2017 Jul 1;199(1):82-90. doi: 10.4049/jimmunol.1601329. Epub 2017 May 26.
- PMID 28550205
- Normalization of regulatory T cells, serum TGF-β1, and LTN after 5-aminolevulinic acid-photodynamic therapy in patients with condyloma acuminate.
- Bu ZY1, Yu XH1, Wu LM1, Zhong JB1, Yang P1, Chen J1.
- Experimental and therapeutic medicine.Exp Ther Med.2017 Jun;13(6):3327-3332. doi: 10.3892/etm.2017.4418. Epub 2017 May 3.
- PMID 28587408
Japanese Journal
- Gene expression profiles in the bovine corpus luteum (CL) during the estrous cycle and pregnancy: Possible roles of chemokines in regulating CL function during pregnancy
- Gene expression profiles in the bovine corpus luteum (CL) during the estrous cycle and pregnancy: possible roles of chemokines in regulating CL function during pregnancy
- A parenteral DNA vaccine protects against pneumonic plague.
Related Links
- Chemokines are a family of small cytokines that are secreted and are involved in immunoregulatory and inflammatory processes. Lymphotactin (LTN) was isolated by ... Comments Single polypeptide chain. Located on human ...
- Species, Scientific Experts, Genomes and Genes, Research Grants, Publications, Research Topics about lymphotactin ... Alias: ATAC, LPTN, LTN, SCM-1, SCM-1a, SCM1, SCM1A, SCYC1, SCM-1-alpha, XC chemokine ligand 1 ...
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