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Lymphomatoid papulosis |
Classification and external resources |
ICD-10 |
L41.2 |
ICD-O: |
9718/1 |
DiseasesDB |
33778 |
eMedicine |
derm/254 |
MeSH |
D017731 |
Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid papulosis is estimated at 1.2 to 1.9 cases per 1,000,000 population.
This rare condition has only been studied in depth since 1968.[1]
Contents
- 1 Presentation
- 2 Prognosis
- 3 Treatment
- 4 See also
- 5 References
Presentation[edit]
It can appear very similar to anaplastic large cell lymphoma.[2]
Type "A" is CD30 positive, while type "B" is CD30 negative.[3]
It has been described as "clinically benign but histologically malignant."[4]
Prognosis[edit]
It can evolve into lymphoma.[5]
Treatment[edit]
It may respond to methotrexate.[6]
See also[edit]
- Cutaneous T-cell lymphoma
- Parapsoriasis
- Secondary cutaneous CD30+ large cell lymphoma
- List of cutaneous conditions
References[edit]
- ^ Macaulay WL (January 1968). "Lymphomatoid papulosis. A continuing self-healing eruption, clinically benign--histologically malignant". Arch Dermatol 97 (1): 23–30. doi:10.1001/archderm.97.1.23. PMID 5634442.
- ^ El Shabrawi-Caelen L, Kerl H, Cerroni L (April 2004). "Lymphomatoid papulosis: reappraisal of clinicopathologic presentation and classification into subtypes A, B, and C". Arch Dermatol 140 (4): 441–7. doi:10.1001/archderm.140.4.441. PMID 15096372.
- ^ Neal S. Young; Stanton L. Gerson; Katherine A. High (2006). Clinical hematology. Elsevier Health Sciences. pp. 555–. ISBN 978-0-323-01908-8. Retrieved 14 May 2011.
- ^ Maria Proytcheva (14 March 2011). Diagnostic Pediatric Hematopathology. Cambridge University Press. pp. 544–. ISBN 978-0-521-88160-9. Retrieved 15 May 2011.
- ^ Dalle S, Balme B, Thomas L (2006). "Lymphomatoid papulosis localized to the face". Dermatol. Online J. 12 (3): 9. PMID 16638423.
- ^ Magro CM, Crowson AN, Morrison C, Merati K, Porcu P, Wright ED (April 2006). "CD8+ lymphomatoid papulosis and its differential diagnosis". Am. J. Clin. Pathol. 125 (4): 490–501. doi:10.1309/NNV4-L5G5-A0KF-1T06. PMID 16627259.
Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
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B cell
(lymphoma,
leukemia)
(most CD19
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By development/
marker
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TdT+
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- ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
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CD5+
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mantle zone (Mantle cell)
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CD22+
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- Prolymphocytic
- CD11c+ (Hairy cell leukemia)
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CD79a+
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- germinal center/follicular B cell (Follicular
- Burkitt's
- GCB DLBCL
- Primary cutaneous follicular lymphoma)
marginal zone/marginal-zone B cell (Splenic marginal zone
- MALT
- Nodal marginal zone
- Primary cutaneous marginal zone lymphoma)
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RS (CD15+, CD30+)
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- Classic Hodgkin's lymphoma (Nodular sclerosis)
- CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
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PCDs/PP
(CD38+/CD138+)
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- see immunoproliferative immunoglobulin disorders
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By infection
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- KSHV (Primary effusion)
- EBV (Lymphomatoid granulomatosis
- Post-transplant lymphoproliferative disorder)
- HIV (AIDS-related lymphoma)
- Helicobacter pylori (MALT lymphoma)
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Cutaneous
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- Diffuse large B-cell lymphoma
- Intravascular large B-cell lymphoma
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous immunocytoma
- Plasmacytoma
- Plasmacytosis
- Primary cutaneous follicular lymphoma
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|
|
T/NK
|
T cell
(lymphoma,
leukemia)
(most CD3
|
By development/
marker
|
- TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
- prolymphocyte (Prolymphocytic)
- CD30+ (Anaplastic large-cell lymphoma
- Lymphomatoid papulosis type A)
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Cutaneous
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MF+variants
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- indolent: Mycosis fungoides
- Pagetoid reticulosis
- Granulomatous slack skin
aggressive: Sézary's disease
- Adult T-cell leukemia/lymphoma
|
|
Non-MF
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- CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
- Pleomorphic T-cell lymphoma
- Lymphomatoid papulosis type B
CD30+: CD30+ cutaneous T-cell lymphoma
- Secondary cutaneous CD30+ large cell lymphoma
- Lymphomatoid papulosis type A
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|
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Other peripheral
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- Hepatosplenic
- Angioimmunoblastic
- Enteropathy-associated T-cell lymphoma
- Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma)
- Subcutaneous T-cell lymphoma
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By infection
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- HTLV-1 (Adult T-cell leukemia/lymphoma)
|
|
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NK cell/
(most CD56)
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- Aggressive NK-cell leukemia
- Blastic NK cell lymphoma
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T or NK
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- EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
- Large granular lymphocytic leukemia
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Lymphoid+myeloid
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- Acute biphenotypic leukaemia
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Lymphocytosis
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- Lymphoproliferative disorders (X-linked lymphoproliferative disease
- Autoimmune lymphoproliferative syndrome)
- Leukemoid reaction
- Diffuse infiltrative lymphocytosis syndrome
|
|
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Cutaneous lymphoid hyperplasia |
- Cutaneous lymphoid hyperplasia
- with bandlike and perivascular patterns
- with nodular pattern
- Jessner lymphocytic infiltrate of the skin
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cell/phys/auag/auab/comp, igrc
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Papulosquamous disorders (L40–L45, 696–697)
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Psoriasis |
Pustular
|
Generalized pustular psoriasis (Impetigo herpetiformis) · Acropustulosis/Pustulosis palmaris et plantaris (Pustular bacterid) · Annular pustular psoriasis · Localized pustular psoriasis
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Other
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Guttate psoriasis · Psoriatic arthritis · Psoriatic erythroderma
Drug-induced psoriasis · Inverse psoriasis · Napkin psoriasis · Seborrheic-like psoriasis
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Parapsoriasis |
Pityriasis lichenoides (Pityriasis lichenoides et varioliformis acuta, Pityriasis lichenoides chronica) · Lymphomatoid papulosis · Small plaque parapsoriasis (Digitate dermatosis, Xanthoerythrodermia perstans) · Large plaque parapsoriasis (Retiform parapsoriasis)
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Other pityriasis |
Pityriasis rosea · Pityriasis rubra pilaris · Pityriasis rotunda · Pityriasis amiantacea
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Other lichenoid |
Lichen planus
|
- configuration
- morphology
- Hypertrophic
- Atrophic
- Bullous
- Ulcerative
- Actinic
- Pigmented
- site
- Mucosal
- Nails
- Peno-ginival
- Vulvovaginal
- overlap synromes
- with lichen sclerosus
- with lupus erythematosis
- other:
- Hepatitis-associated lichen planus
- Lichen planus pemphigoides
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Other
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Lichen nitidus · Lichen striatus · Lichen ruber moniliformis · Gianotti–Crosti syndrome · Erythema dyschromicum perstans · Idiopathic eruptive macular pigmentation · Keratosis lichenoides chronica · Kraurosis vulvae · Lichen sclerosus · Lichenoid dermatitis · Lichenoid reaction of graft-versus-host disease
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noco (i/b/d/q/u/r/p/m/k/v/f)/cong/tumr (n/e/d), sysi/epon
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proc, drug (D2/3/4/5/8/11)
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UpToDate Contents
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English Journal
- Lymphomatoid papulosis presenting as periarticular nodules - a rare variant.
- Dumke AK, Metz S, Schliemann S, Tittelbach J, Reindl H, Kempf W, Elsner P.SourceMedical University Jena, Department of Dermatology, Jena, Germany.
- Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.J Dtsch Dermatol Ges.2013 Nov 18. doi: 10.1111/ddg.12234. [Epub ahead of print]
- PMID 24238474
- Lymphomatoid Papulosis Type D or an Aggressive Epidermotropic CD8 Cytotoxic T-cell Lymphoma?
- Andersen RM, Skaarup Larsen M, Svenstrup Poulsen T, Falensteen Lauritzen A, Skov L.SourceDepartment of Dermato-Allergology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark.
- Acta dermato-venereologica.Acta Derm Venereol.2013 Nov 12. doi: 10.2340/00015555-1750. [Epub ahead of print]
- Abstract is missing (Short).
- PMID 24217891
Japanese Journal
- 山本 悠飛,佐々木 哲雄,鈴木 亜希 [他]
- 臨床皮膚科 = Japanese journal of clinical dermatology 68(13), 1055-1058, 2014-12
- NAID 40020279310
- 治療 Narrow-band UVB療法が有効であったCD8陽性Lymphomatoid Papulosis
Related Links
- Lymphomatoid papulosis (LyP) is a recurrent, self-healing papulonodular skin eruption with histologic features of a CD30+malignant T cell lymphoma. LyP is part of the group of cutaneous CD30+lymphoproliferative disorders (LPDs ...
- Item107 リンパ腫様丘疹症:Lymphomatoid papulosis 臨床症状 1. 男性に約2倍多い。 2. 50歳代の発症が多い。 3. 皮疹は、数個から数十個の、直径0.5-1.0cmまでの無症状の紅色丘疹で発症する。 4. 3-4週の経過で出血や壊死を 伴 ...
Related Pictures
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- 英
- lymphomatoid papulosis