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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/10 20:44:04」(JST)

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Lipiodol (labeled Ethiodol in the USA), also known as ethiodized oil, is a poppyseed oil used by injection as a radio-opaque contrast agent that is used to outline structures in radiological investigations.^[1]^[2] It is used in chemoembolization applications as a contrast agent in follow-up imaging.^[3] Lipiodol is also used in lymphangiography, the imaging of the lymphatic system.^[4] It has an additional use in gastric variceal obliteration as a dilutant that does not affect polymerization of cyanoacrylate.

Recently there has been an increasing interest in the use of Lipiodol as a therapeutic agent in the management of unexplained infertility, using a procedure called Lipiodol flushing. There have been a small number of studies that suggest that flushing the media through the tubes gives a short-term rise in fecundity in patients with unexplained infertility. A systematic review has suggested a significant increase in fertility, especially in those women who have endometriosis when using Lipiodol flushing.^[5]

Historically Lipiodol was often used as a contrast medium at hysterosalpingography (HSG: a procedure to determine tubal patency, used in the investigation of subfertility). It became less commonly utilised in the 1960s to 1980s because the more modern water-soluble media give images that are easier to interpret. There is also an important safety issue with Lipiodol in that intravasation (leakage) of the fluid into the venous system has caused complications in the past.

Ethiodized oil is composed of iodine combined with ethyl esters of fatty acids of poppyseed oil, primarily as ethyl monoiodostearate and ethyl diiodostearate. The precise structure is not known. Lipiodol was first synthesized by Marcel Guerbet in the Paris School of Pharmacy in 1901. Historically, Lipiodol was the first iodinated contrast agent (used for myelography by two French physicians, Jacques Forestier and Jean Sicard in 1921).

Lipiodol is now solely produced and marketed by Guerbet since Savage Laboratories discontinued manufacturing in 2010.^[6]

References

^ Ahrar, K.; Gupta, S. (Jan 2003). "Hepatic artery embolization for hepatocellular carcinoma: technique, patient selection, and outcomes.". Surg Oncol Clin N Am 12 (1): 105–26. doi:10.1016/s1055-3207(02)00089-3. PMID 12735133.
^ Sato, T. (Apr 2002). "Locoregional immuno(bio)therapy for liver metastases.". Semin Oncol 29 (2): 160–7. doi:10.1053/sonc.2002.31716. PMID 11951214.
^ Guan, YS.; Hu, Y.; Liu, Y. (Jun 2006). "Multidetector-row computed tomography in the management of hepatocellular carcinoma with transcatheter arterial chemoembolization.". J Gastroenterol Hepatol 21 (6): 941–6. doi:10.1111/j.1440-1746.2006.04474.x. PMID 16724976.
^ Cabanas, RM. (2000). "The concept of the sentinel lymph node.". Recent Results Cancer Res 157: 109–20. doi:10.1007/978-3-642-57151-0_9. PMID 10857165.
^ Johnson, NP. (2005). "A review of the use of lipiodol flushing for unexplained infertility.". Treat Endocrinol 4 (4): 233–43. doi:10.2165/00024677-200504040-00004. PMID 16053340.
^ http://www.guerbet-us.com/?page=lipiodol

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1. 切除可能な肝細胞癌のマネージメント：予後、術前補助化学療法と補助化学療法の役割、および治療後サーベイランス management of potentially resectable hepatocellular carcinoma prognosis role of neoadjuvant and adjuvant therapy and posttreatment surveillance
2. 局所性肝細胞癌に対する非外科的治療：動脈塞栓術、放射線療法、および放射線塞栓療法 nonsurgical therapies for localized hepatocellular carcinoma transarterial embolization radiotherapy and radioembolization
3. 肝胆道のCT撮影 computed tomography of the hepatobiliary tract
4. 限局性胆管癌の治療：補助化学療法および術前補助化学療法と予後 treatment of localized cholangiocarcinoma adjuvant and neoadjuvant therapy and prognosis
5. 大腸癌の肝転移に対する非外科的局所治療戦略 nonsurgical local treatment strategies for colorectal cancer liver metastases

English Journal

Research of novel biocompatible radiopaque microcapsules for arterial embolization.

Lu XJ, Zhang Y, Cui DC, Meng WJ, Du LR, Guan HT, Zheng ZZ, Fu NQ, Lv TS, Song L, Zou YH, Lu WL, Fan TY.SourceDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
International journal of pharmaceutics.Int J Pharm.2013 Aug 16;452(1-2):211-9. doi: 10.1016/j.ijpharm.2013.05.001. Epub 2013 May 22.
Embolic agents, such as microparticles, microspheres or beads used in current embolotherapy are mostly radiolucent, which means the agents are invisible under X-ray imaging during and after the process of embolization, and the fate of these particles cannot be precisely assessed. In this research, a
PMID 23707965

Clinical implementations of preoperative computed tomography lymphography in gastric cancer: a comparison with dual tracer methods in sentinel node navigation surgery.

Lee JH, Park do J, Kim YH, Shin CM, Lee HS, Kim HH.SourceDepartment of Surgery, Seoul National University Bundang Hospital, Gyeonggi, South Korea.
Annals of surgical oncology.Ann Surg Oncol.2013 Jul;20(7):2296-303. doi: 10.1245/s10434-012-2855-8. Epub 2013 Jan 22.
BACKGROUND: Current sentinel node (SN) detection techniques require a learning period and tracers have many disadvantages for practical use. The purpose of this study was to evaluate the feasibility of preoperative computed tomography (CT) lymphography using lipiodol for detecting SNs in gastric can
PMID 23338481

Japanese Journal

Direct-Puncture Embolization of Scalp Arteriovenous Fistulae : Technical Note on the Circular Compression Device

YOUN Sung Won,LEE Nam Joon,SUH Sang Il,KANG Sin Hyuk
Neurologia medico-chirurgica = 神経外科 52(7), 525-528, 2012-07-15
… While maintaining flow stasis within the boundary of the CCD and loading heparinized dextrose-saline solution, a 50% mixture of N-butyl-2-cyanoacrylate and Lipiodol was applied during the compression, which was sustained for 1-2 minutes. …
NAID 10030694411

食道癌術後乳糜胸に対してリピオドールを用いたリンパ管造影が奏功した1例

鴻巣正史,木村祐輔,岩谷岳 [他],秋山有史,箱崎将規,藤原久貴,肥田圭介,若林剛
岩手医学雑誌 64(1), 63-69, 2012-04-01
NAID 110009422860

Related Pictures

phase image- HCC in right lobe. Lipiodol Lipiodol Ultra Fluido Lipiodol® Ultra-Fluide (480 mg I/ml T2009.002.467 Lipiodol Lafay LİPİODOL ULTRA FLUİDE 480MG/10 ML 1 Lipiodol UF (gejodeerde olie LIPIODOL ULTRA-FLUID Feature of Lipiodol drug

★リンクテーブル★

リンク元

「リピオドール」

Lipiodol
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
ATC code	?
ChEMBL	CHEMBL1201458
Chemical data
Formula	?

　　[★]

英: lipiodol
関: ヨード化ケシ油脂肪酸エチルエステル

商品名である。

肝癌のTACE療法に利用されている

油性造影剤（イオダイズドオイル：リピオドール）が腫瘍内に蓄積する事実がわかり、リピオドールと抗癌剤の混合液（リピオドールエマルジョン）注入（以下リピオドリゼーション）後塞栓物質を注入する化学塞栓療法（transcatheter arterial chemoembolization; TACE）が施行されるようになってきた(肝癌ガイドラインより)

肝腫瘍に長期集積する性質がある。

[1] Ahrar, K.; Gupta, S. (Jan 2003). "Hepatic artery embolization for hepatocellular carcinoma: technique, patient selection, and outcomes.". Surg Oncol Clin N Am 12 (1): 105–26. doi:10.1016/s1055-3207(02)00089-3. PMID 12735133.

[2] Sato, T. (Apr 2002). "Locoregional immuno(bio)therapy for liver metastases.". Semin Oncol 29 (2): 160–7. doi:10.1053/sonc.2002.31716. PMID 11951214.

[3] Guan, YS.; Hu, Y.; Liu, Y. (Jun 2006). "Multidetector-row computed tomography in the management of hepatocellular carcinoma with transcatheter arterial chemoembolization.". J Gastroenterol Hepatol 21 (6): 941–6. doi:10.1111/j.1440-1746.2006.04474.x. PMID 16724976.

[4] Cabanas, RM. (2000). "The concept of the sentinel lymph node.". Recent Results Cancer Res 157: 109–20. doi:10.1007/978-3-642-57151-0_9. PMID 10857165.

[Johnson-2005-5] Johnson, NP. (2005). "A review of the use of lipiodol flushing for unexplained infertility.". Treat Endocrinol 4 (4): 233–43. doi:10.2165/00024677-200504040-00004. PMID 16053340.

[6] ttp://www.guerbet-us.com/?page=lipiodol

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lipiodol