levopropoxyphene

Levopropoxyphene
	IUPAC name (1R,2S)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propionate
	Other names [(2R,3S)-4-dimethylamino-3-methyl-1,2-diphenyl-butan-2-yl]propanoate
Identifiers
CAS number	2338-37-6
PubChem	200742
ChemSpider	173777
ChEMBL	CHEMBL1213351
Jmol-3D images	Image 1
	SMILES O=C(O[C@](c1ccccc1)(Cc2ccccc2)[C@@H](C)CN(C)C)CC ;
	InChI InChI=1S/C22H29NO2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19/h6-15,18H,5,16-17H2,1-4H3/t18-,22+/m0/s1 ; Key: XLMALTXPSGQGBX-PGRDOPGGSA-N InChI=1/C22H29NO2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19/h6-15,18H,5,16-17H2,1-4H3/t18-,22+/m0/s1; Key: XLMALTXPSGQGBX-PGRDOPGGBE ;
Properties
Molecular formula	C22H29NO2
Molar mass	339.47 g mol−1
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/12 08:41:27」(JST)

Wainer IW1.
American journal of hospital pharmacy.Am J Hosp Pharm.1992 Sep;49(9 Suppl 1):S4-8.
The relationship between the stereochemistry of drugs and their therapeutic and toxic effects is discussed. Molecular structures that have the same chemical constituents and are related to each other as an object and its nonsuperimposable mirror image are enantiomers. A molecule that has at least on
PMID 1530004

High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments.

Craviso GL, Musacchio JM.
Molecular pharmacology.Mol Pharmacol.1983 May;23(3):629-40.
Binding of dextromethorphan (DM) to guinea pig brain is stereoselective, since levomethorphan is 20 times weaker than DM in competing for DM sites. In general, opiate agonists and antagonists as well as their corresponding dextrorotatory isomers are weak competitors for tritiated dextromethorphan ([
PMID 6865909

Reduction of levopropoxyphene N-oxide to propoxyphene by dogs in vivo and rat liver microsomal fraction in vitro.

McMahon RE, Sullivan HR.
Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.1977 Jun;7(6):377-82.
1. When l-propoxyphene-N-oxide was given orally to dogs, reduction occurred in vivo resulting in substantial plasma levels of l-propoxyphene. 2. When l-propoxyphene-N-oxide was given intravenously, near peak plasma levels of propoxyphene occurred in 10 minutes. This suggests that reduction is occurr
PMID 610054