レプチン受容体、レプチンレセプター

WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/27 07:52:06」(JST)

wiki en

Leptin receptor also known as LEP-R or OB-R is a protein that in humans is encoded by the LEPR gene.^[5]^[6] LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 (cluster of differentiation 295).

After co-discovering the Leptin gene with Jeffrey Friedman et al. in 1994, which involved a reverse genetic/positional cloning strategy to clone ob and db, Rudolph Leibel, working with collaborators at Millennium Pharmaceuticals and colleague Streamson Chua, confirmed cloning of the leptin receptor by demonstrating that an apparent leptin receptor cloned from a choroid plexus library using leptin as ligand, mapped to a physical map that included db and fa.^[7]

Function

The leptin hormone regulates adipose-tissue mass through hypothalamus effects on hunger and energy use. It acts through the leptin receptor (LEP-R), a single-transmembrane-domain receptor of the cytokine receptor family.^[8] In hypothalamic neurons, adequate leptin receptor function and subsequent regulation of energy metabolism and body weight depends on interactions of the receptor with gangliosides in the cell membrane.^[9]

Clinical significance

Variations in the leptin receptor have been associated with obesity^[10]^[11] and with increased susceptibility to Entamoeba histolytica infections.^[12]

Animals models

The db/db mouse is a model of obesity, diabetes, and dyslipidemia wherein leptin receptor activity is deficient because the mice are homozygous for a point mutation in the gene for the leptin receptor.^[13] In db/db mice, induced swimming helped to overcome obesity by upregulating uncoupling proteins.^[14]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116678 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057722 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI (Feb 1996). "Identification and expression cloning of a leptin receptor, OB-R". Cell. 83 (7): 1263–71. PMID 8548812. doi:10.1016/0092-8674(95)90151-5.
^ Winick JD, Stoffel M, Friedman JM (Feb 1997). "Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1". Genomics. 36 (1): 221–2. PMID 8812446. doi:10.1006/geno.1996.0455.
^ Leibel RL (Dec 2008). "Molecular physiology of weight regulation in mice and humans". Int J Obes. 32 (S7): S98–108. PMC 2682360 . PMID 19136999. doi:10.1038/ijo.2008.245.
^ "Entrez Gene: LEPR leptin receptor".
^ Nordström V, Willershäuser M, Herzer S, Rozman J, von Bohlen und Halbach O, Meldner S; et al. (March 12, 2013). "Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis". PLoS Biology. 11 (3): e1001506. PMC 3595213 . PMID 23554574. doi:10.1371/journal.pbio.1001506.
^ Considine RV, Considine EL, Williams CJ, Nyce MR, Zhang P, Opentanova I, Ohannesian JP, Kolaczynski JW, Bauer TL, Moore JH, Caro JF (March 1996). "Mutation screening and identification of a sequence variation in the human ob gene coding region". Biochem. Biophys. Res. Commun. 220 (3): 735–9. PMID 8607834. doi:10.1006/bbrc.1996.0473.
^ Masuo K, Straznicky NE, Lambert GW, Katsuya T, Sugimoto K, Rakugi H, Socratous F, Hastings J, Lambert EA, Ogihara T, Esler MD (June 2008). "Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population". Hypertens. Res. 31 (6): 1093–100. PMID 18716356. doi:10.1291/hypres.31.1093.
^ Duggal P, Guo X, Haque R, Peterson KM, Ricklefs S, Mondal D, Alam F, Noor Z, Verkerke HP, Marie C, Leduc CA, Chua SC, Myers MG, Leibel RL, Houpt E, Gilchrist CA, Sher A, Porcella SF, Petri WA (March 2011). "A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children". J. Clin. Invest. 121 (3): 1191–8. PMC 3049405 . PMID 21393862. doi:10.1172/JCI45294.
^ Sharma K, McCue P, Dunn SR (June 2003). "Diabetic kidney disease in the db/db mouse". Am. J. Physiol. Renal Physiol. 284 (6): F1138–44. PMID 12736165. doi:10.1152/ajprenal.00315.2002.
^ Oh KS, Kim EY, Yoon M, Lee CM (June 2007). "Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins". Experimental & Molecular Medicine. 39 (3): 385–94. PMID 17603293. doi:10.1038/emm.2007.43.

External links

LEPR protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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1. レプチンの生理学physiology of leptin [show details]
…Leptin is a product of the ob gene, which is expressed primarily in adipocytes. Leptin acts on leptin receptors (LEPRs), which are widely distributed and account for its pleiotropic effects on energy homeostasis …
2. 肥満への遺伝的影響と病態生理genetic contribution and pathophysiology of obesity [show details]
…defects in the leptin receptor. db mice are phenotypically identical to ob mice, indicating that obesity can be caused by a deficiency of leptin or by a genetic defect in the leptin receptor. Human obesity …
3. 2型糖尿病の病因pathogenesis of type 2 diabetes mellitus [show details]
…in peripheral tissues, such as the pancreas . In a preliminary study of a pancreas-specific, leptin receptor-knockout (KO) mouse model, the absence of leptin signaling was associated with improved glucose …
4. 脂肪異栄養症症候群lipodystrophic syndromes [show details]
5. 非アルコール性脂肪性肝疾患の病因pathogenesis of nonalcoholic fatty liver disease [show details]

English Journal

Genetic polymorphisms of IL-23R (rs7517847) and LEP (rs7799039) among Egyptian patients with hepatocellular carcinoma.

Amer T1, El-Baz R2, Mokhtar AR3, El-Shaer S1, Elshazli R4, Settin A2.
Archives of physiology and biochemistry.Arch Physiol Biochem.2017 Dec;123(5):279-285. doi: 10.1080/13813455.2017.1320680. Epub 2017 Apr 28.
PMID 28452232

Globular adiponectin reverses osteo-sarcopenia and altered body composition in ovariectomized rats.

China SP1, Pal S2, Chattopadhyay S3, Porwal K2, Kushwaha S4, Bhattacharyya S2, Mittal M1, Gurjar AA3, Barbhuyan T2, Singh AK4, Trivedi AK4, Gayen JR5, Sanyal S6, Chattopadhyay N7.
Bone.Bone.2017 Dec;105:75-86. doi: 10.1016/j.bone.2017.08.005. Epub 2017 Aug 12.
PMID 28811200

Inhibition of protein tyrosine phosphatase (PTP1B) and α-glucosidase by geranylated flavonoids from Paulownia tomentosa.

Song YH1, Uddin Z1, Jin YM1, Li Z1, Curtis-Long MJ2, Kim KD3, Cho JK1, Park KH1.
Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2017 Dec;32(1):1195-1202. doi: 10.1080/14756366.2017.1368502.
PMID 28933230

Japanese Journal

ADCY3遺伝子異常と肥満

黒田雅士,三島優奈,阪上浩
内分泌・糖尿病・代謝内科 = Endocrinology, diabetology & metabolism 48(3), 214-218, 2019-03
NAID 40021856391

Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ

CHISADA Shinichi,SUGIYAMA Akihiko
Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ, 2019
… The aim of this study was to elucidate the renal lesions of leptin receptor-deficient medaka showing hyperglycemia and hypoinsulinemia and to evaluate the usefulness of the medaka as a model of diabetic nephropathy. … Leptin receptor-deficient medaka at 20 and 30 weeks of age showed hyperglycemia and hypoinsulinemia; …
NAID 130007661740

Combinational Effect of Pine Needle Polysaccharide and Kudzu Flavonoids on Cell Differentiation and Fat Metabolism in 3T3-L1 Cells

Liu Ji-Luan,Yang Li-Cong,Zhu Xiao-Juan,Wang We-Jun,Zheng Guo-Dong
Food Science and Technology Research 24(5), 903-910, 2018
… (peroxisome proliferator activated receptor-γ2), C/EBPα … In addition, the gene expression and secretion of leptin and IL-6 were inhibited, adiponectin was significantly increased, secretion of TNF-α was inhibited by PNP and KF combination. …
NAID 130007501337

「レプチンレセプター」

LEPR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3V6O
Identifiers
Aliases	LEPR, CD295, LEP-R, LEPRD, OB-R, OBR, leptin receptor
External IDs	MGI: 104993 HomoloGene: 1731 GeneCards: LEPR
Gene location (Human)
Chr.	Chromosome 1 (human)
End	65,641,559 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	101,815,352 bp
Gene ontology
Molecular function	• leptin receptor activity; • protein binding; • identical protein binding; • cytokine receptor activity; • transmembrane signaling receptor activity;
Cellular component	• integral component of membrane; • membrane; • receptor complex; • plasma membrane; • extracellular region; • basolateral plasma membrane;
Biological process	• sexual reproduction; • glucose homeostasis; • leptin-mediated signaling pathway; • cholesterol metabolic process; • negative regulation of hydrolase activity; • regulation of feeding behavior; • multicellular organism development; • negative regulation of gluconeogenesis; • cell surface receptor signaling pathway; • T cell differentiation; • angiogenesis; • energy homeostasis; • bone growth; • energy reserve metabolic process; • response to leptin; • negative regulation of autophagy; • regulation of energy homeostasis; • regulation of bone remodeling; • phagocytosis;
	Sources:Amigo / QuickGO
Orthologs
	3953
	16847
	ENSG00000116678
	ENSMUSG00000057722
	P48357
	P48356
NM_002303; NM_001003679; NM_001003680; NM_001198687; NM_001198688;
	NM_001198689
	NM_001122899; NM_010704; NM_146146
NP_001003679; NP_001003680; NP_001185616; NP_001185617; NP_001185618;
	NP_002294
	NP_001116371; NP_034834; NP_666258
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: leptin receptor
関: レプチン受容体

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116678 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057722 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8548812-5] Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI (Feb 1996). "Identification and expression cloning of a leptin receptor, OB-R". Cell. 83 (7): 1263–71. PMID 8548812. doi:10.1016/0092-8674(95)90151-5.

[pmid8812446-6] Winick JD, Stoffel M, Friedman JM (Feb 1997). "Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1". Genomics. 36 (1): 221–2. PMID 8812446. doi:10.1006/geno.1996.0455.

[pmid19136999-7] Leibel RL (Dec 2008). "Molecular physiology of weight regulation in mice and humans". Int J Obes. 32 (S7): S98–108. PMC 2682360 . PMID 19136999. doi:10.1038/ijo.2008.245.

[8] "Entrez Gene: LEPR leptin receptor".

[9] Nordström V, Willershäuser M, Herzer S, Rozman J, von Bohlen und Halbach O, Meldner S; et al. (March 12, 2013). "Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis". PLoS Biology. 11 (3): e1001506. PMC 3595213 . PMID 23554574. doi:10.1371/journal.pbio.1001506.

[pmid8607834-10] Considine RV, Considine EL, Williams CJ, Nyce MR, Zhang P, Opentanova I, Ohannesian JP, Kolaczynski JW, Bauer TL, Moore JH, Caro JF (March 1996). "Mutation screening and identification of a sequence variation in the human ob gene coding region". Biochem. Biophys. Res. Commun. 220 (3): 735–9. PMID 8607834. doi:10.1006/bbrc.1996.0473.

[pmid18716356-11] Masuo K, Straznicky NE, Lambert GW, Katsuya T, Sugimoto K, Rakugi H, Socratous F, Hastings J, Lambert EA, Ogihara T, Esler MD (June 2008). "Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population". Hypertens. Res. 31 (6): 1093–100. PMID 18716356. doi:10.1291/hypres.31.1093.

[pmid21393862-12] Duggal P, Guo X, Haque R, Peterson KM, Ricklefs S, Mondal D, Alam F, Noor Z, Verkerke HP, Marie C, Leduc CA, Chua SC, Myers MG, Leibel RL, Houpt E, Gilchrist CA, Sher A, Porcella SF, Petri WA (March 2011). "A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children". J. Clin. Invest. 121 (3): 1191–8. PMC 3049405 . PMID 21393862. doi:10.1172/JCI45294.

[pmid12736165-13] Sharma K, McCue P, Dunn SR (June 2003). "Diabetic kidney disease in the db/db mouse". Am. J. Physiol. Renal Physiol. 284 (6): F1138–44. PMID 12736165. doi:10.1152/ajprenal.00315.2002.

[pmid17603293-14] Oh KS, Kim EY, Yoon M, Lee CM (June 2007). "Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins". Experimental & Molecular Medicine. 39 (3): 385–94. PMID 17603293. doi:10.1038/emm.2007.43.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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leptin receptor