English Journal

Sutton KS1, Dasgupta A1, McCarty D1, Doering CB1, Spencer HT2.
Cytotherapy.Cytotherapy.2016 Jul;18(7):881-92. doi: 10.1016/j.jcyt.2016.04.001.
BACKGROUND AIMS: Cellular immunotherapy relies on several highly variable patient-specific parameters, such as (i) cell number before and after expansion, (ii) targeting of cells to tumors, (iii) cell survival and function after infusion, and (iv) on- and off-target adverse events. Cellular approach
PMID 27260209

Injectable alginate hydrogel for enhanced spatiotemporal control of lentivector delivery in murine skeletal muscle.

Stilhano RS1, Madrigal JL2, Wong K2, Williams PA2, Martin PK1, Yamaguchi FS3, Samoto VY1, Han SW4, Silva EA5.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2016 Jul 1;237:42-49. doi: 10.1016/j.jconrel.2016.06.047. [Epub ahead of print]
Hydrogels are an especially appealing class of biomaterials for gene delivery vehicles as they can be introduced into the body with minimally invasive procedures and are often applied in tissue engineering and regenerative medicine strategies. In this study, we show for the first time the use of an
PMID 27374631

A novel dendritic cell-targeted lentiviral vector, encoding Ag85A-ESAT6 fusion gene of Mycobacterium tuberculosis, could elicit potent cell-mediated immune responses in mice.

Shakouri M1, Moazzeni SM2, Ghanei M3, Arashkia A4, Etemadzadeh MH5, Azadmanesh K6.
Molecular immunology.Mol Immunol.2016 Jul;75:101-11. doi: 10.1016/j.molimm.2016.04.014. Epub 2016 Jun 3.
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), leading to high mortality worldwide. It is well-established that cellular immunity plays a critical role to control Mtb infection. Dendritic Cells (DCs) are potent antigen presenting cells, which play an important
PMID 27267270

Japanese Journal

Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection

Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment

Third-generation, self-inactivating gp91 (phox) lentivector corrects the oxidase defect in NOD/SCID mouse-repopulating peripheral blood-mobilized CD34+ cells from patients with X-linked chronic granulomatous disease