Topical surfactant-induced pruritus: Involvement of histamine released from epidermal keratinocytes.
Inami Y, Andoh T, Sasaki A, Kuraishi Y.SourceUniversity of Toyama.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2012 Dec 5. [Epub ahead of print]
Surfactants, an important component of cleansers, often cause itch in humans. Topical application of sodium laurate and N-lauroylsarcosine sodium salt to the skin of mice immediately (for 1-1.5 h) increased scratching, and the former increased scratching again between 2 and 3 h after application. Th
Surfactant-induced Itching and the Involvement of Histamine Released from Keratinocytes.
Inami Y, Andoh T, Sasaki A, Kuraishi Y.SourceDepartment of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.Yakugaku Zasshi.2012;132(11):1225-30.
The primary function of surfactants is to remove dirt, exfoliated corneum cells, and microorganisms from the skin. However, the use of toiletries such as soaps and shampoos containing surfactants may cause adverse effects such as cutaneous irritation, dryness, and itching. Recently, skin pathologies
… We found that topical application of an anionic surfactant sodium laurate at an alkaline pH, but not N-lauroylsarcosine sodium salt at neutral pH, to mouse skin induced scratching, an itch-related response. …
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