knockdown

WordNet

(furniture) easily assembled and dismantled; "I bought a knockdown chest at the do-it-yourself store"
a blow that knocks the opponent off his feet
extremely violent; "a knock-down-and-drag-out fight" (同)knock-down-and-drag-out

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/17 08:10:00」(JST)

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Negative modulation of the epigenetic regulator, UHRF1, by thyroid hormone receptors suppresses liver cancer cell growth.

Wu SM1, Cheng WL, Liao CJ, Chi HC, Lin YH, Tseng YH, Tsai CY, Chen CY, Lin SL, Chen WJ, Yeh YH, Huang CY, Chen MH, Yeh YC, Lin KH.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Jul 1;137(1):37-49. doi: 10.1002/ijc.29368. Epub 2014 Dec 10.
The thyroid hormone, 3,3',5-triiodo-l-thyronine (T3 ), mediates several physiological processes, including embryonic development, cellular differentiation, metabolism and regulation of cell proliferation. Thyroid hormone (T3 ) and its receptor (TR) are involved in metabolism and growth. In addition
PMID 25430639

TGF-β1 up-regulates connexin43 expression: A potential mechanism for human trophoblast cell differentiation.

Cheng JC1, Chang HM, Fang L, Sun YP, Leung PC.
Journal of cellular physiology.J Cell Physiol.2015 Jul;230(7):1558-66. doi: 10.1002/jcp.24902.
Connexin43 (Cx43)-mediated gap junctional intercellular communication (GJIC) are required for human trophoblast differentiation. To date, whether Cx43 mediates TGF-β1-induced trophoblast differentiation has not been determined. We showed that treatment with TGF-β1 increased Cx43 expression and GJI
PMID 25560303

Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia.

Tsuboi I1, Yamashita T, Nagano M, Kimura K, To'a Salazar G, Ohneda O.
Journal of cellular physiology.J Cell Physiol.2015 Jul;230(7):1534-48. doi: 10.1002/jcp.24899.
Erythropoiesis is strongly influenced by the interactions between stromal cells and erythroid progenitors, as well as by a key regulatory factor, erythropoietin (EPO). We previously generated mice with a knockdown mutation of Hif-2α (referred to as kd/kd) and found that these kd/kd mice exhibited n
PMID 25557133

Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1.

Zhang X1, Liang D2, Guo L3, Liang W1, Jiang Y1, Li H2, Zhao Y4, Lu S1, Chi ZH5.
Molecular medicine reports.Mol Med Rep.2015 Jul;12(1):1347-55. doi: 10.3892/mmr.2015.3556. Epub 2015 Mar 27.
Curcumin has been observed to exhibit an anti-fibrotic effect in the liver, lung and gallbladder. However, the mechanisms underlying the cytoprotective effects of curcumin remain to be elucidated. The epithelial‑to‑mesenchymal transition (EMT) of mature tubular epithelial cells in the kidney is
PMID 25823828

Chaves Luis Fernando,Kawashima Emiko,Futami Kyoko,Minakawa Noboru,Marin Rodriguez Rodrigo
Bulletin of Insectology 68(1), 61-63, 2015-06
… Use of insecticides has led to the fixation of alleles for single amino acid changes in the voltage gated sodium channel (VGSC) associated with knockdown resistance (kdr) in insects of agricultural or medical importance. …
NAID 120005611340

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

Watanabe Masashi,Takahashi Hidehisa,Saeki Yasushi,Ozaki Takashi,Itoh Shihori,Suzuki Masanobu,Mizushima Wataru,Tanaka Keiji,Hatakeyama Shigetsugu
Elife 4, e05615, 2015-04-23
… TRIM23 knockdown caused a marked decrease in PPAR gamma protein abundance during preadipocyte differentiation, resulting in a severe defect in late adipogenic differentiation, whereas it did not affect the formation of early enhanceosomes. …
NAID 120005617283

NLRP3 Mediates NF-κB activation and cytokine induction in microbially induced and sterile inflammation

Kinoshita Takeshi,Imamura Ryu,Kushiyama Hiroko,Suda Takashi
PLoS ONE 10(3), e0119179, 2015-03-15
… To clarify the physiological relevance of this latter function, we examined the effect of NLRP3 on NF-κB activation and cytokine induction in RNA-interferencebased NLRP3-knockdown cell lines generated from the human monocytic cell line THP-1. …
NAID 120005611526