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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/01 22:22:42」(JST)

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Kitasamycin (INN) is a macrolide antibiotic. It is produced by streptomyces kitasatoensis.^{[citation needed]} The drug has antimicrobial activity against a wide spectrum of pathogens. There are several generic names of this drug such as-

•Kitasamycin (OS: BAN, JAN, USAN)

•Kitasamycine (OS: DCF) •C 637 (IS) •Katasamycin (IS) •Leucomycin (IS) •Kitasamycin (PH: JP XV) •Kitasamycin Acetate (OS: JAN) •Leucomycin Acetate (IS) •Kitasamycin Acetate (PH: JP XV) •Kitasamycin Tartrate (OS: JAN) •Leucomycin Tartrate (IS) •Kitasamycin Tartrate (PH: JP XV)

("Kitasamycin." - Drugs.com. N.p., n.d. Web. 05 July 2013.)

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English Journal

Decline in extractable kitasamycin during the composting of kitasamycin manufacturing waste with dairy manure and sawdust.

Ding N1, Li W2, Liu C1, Fu Q1, Guo B3, Li H1, Li N1, Lin Y1.Author information 1Institute of Environment, Resource, Soil and Fertilizer, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.2Department of Science, Qianjiang College of Hangzhou Normal University, Hangzhou 310012, China.3Institute of Environment, Resource, Soil and Fertilizer, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. Electronic address: ndgb@163.com.AbstractThe aim of this study was to propose a feasible treatment of kitasamycin manufacturing waste by examining extractable kitasamycin and evaluating its compost maturity during the composting of waste with different ratios of dairy manure and sawdust over a 40-day period (volume/volume/volume; M1, 0/80/20; M2, 10/70/20; and M3, 30/50/20). During composting, the concentration of extractable kitasamycin in kitasamycin-contaminated composts declined rapidly, and was undetectable in M2 within 15 days. M2 also achieved the highest fertility compost, which was characterised by the following final parameters: electrical conductivity, 2.34 dS cm(-1); pH, 8.15; total C/N, 22.2; water-soluble NH4(+), P, and K, 0.37, 3.43, and 1.05 g kg(-1), respectively; and plant germination index values, 92%. Furthermore, DGGE analysis showed a dramatic increase in the diversity of bacterial species during composting. In contrast, a high concentration (121 mg kg(-1)) of extractable kitasamycin still remained in the M3 compost, which exerted an inhibitory effect on the composting, resulting in reduced bacterial diversity, high values of electrical conductivity and water-soluble NH4(+), a low C/N ratio, and a low plant germination index value. Furthermore, 3.86 log (CFU g(-1)) kitasamycin-resistant bacteria were still present on day 40, indicating the biological degradation contributed to the decline of extractable kitasamycin.
Journal of environmental management.J Environ Manage.2014 Feb 15;134:39-46. doi: 10.1016/j.jenvman.2013.12.030. Epub 2014 Jan 23.
The aim of this study was to propose a feasible treatment of kitasamycin manufacturing waste by examining extractable kitasamycin and evaluating its compost maturity during the composting of waste with different ratios of dairy manure and sawdust over a 40-day period (volume/volume/volume; M1, 0/80/
PMID 24463847

Monoclonal antibody production and the development of an indirect competitive enzyme-linked immunosorbent assay for screening spiramycin in milk.

Jiang W1, Zhang H, Li X, Liu X, Zhang S, Shi W, Shen J, Wang Z.Author information 1College of Veterinary Medicine, China Agricultural University , Beijing 100193, People's Republic of China.AbstractTo monitor spiramycin (SP) residue in milk, a monoclonal antibody (mAb)-based indirect competitive enzyme-linked immunosorbent assay (icELISA) was developed. This study described the preparation of three immunogens and the production of a high-affinity mAb. After optimization, the 50% inhibition concentration (IC50) for the developed icELISA was estimated as 0.97 ng/mL in the assay buffer, and the limit of detection and limit of quantitation were 2.51 and 4.40 μg/L in the milk matrix. The newly developed assay demonstrated negligible cross-reactivity with 15 other macrolide antibiotics, but not with kitasamycin (23.4%). The mean recoveries ranged from 81 to 103% for the spiked samples (5, 10, and 50 μg/L), and the coefficient of variation ranged from 5.4 to 9.6%. The icELISA was validated by LC-MS/MS method, and all results demonstrated that it was a suitable screening method for detecting SP residue in milk without requiring a cleanup process.
Journal of agricultural and food chemistry.J Agric Food Chem.2013 Nov 20;61(46):10925-31. doi: 10.1021/jf404027b. Epub 2013 Nov 5.
To monitor spiramycin (SP) residue in milk, a monoclonal antibody (mAb)-based indirect competitive enzyme-linked immunosorbent assay (icELISA) was developed. This study described the preparation of three immunogens and the production of a high-affinity mAb. After optimization, the 50% inhibition con
PMID 24147865

Effects of the antimicrobial peptide cecropin AD on performance and intestinal health in weaned piglets challenged with Escherichia coli.

Wu S1, Zhang F, Huang Z, Liu H, Xie C, Zhang J, Thacker PA, Qiao S.Author information 1State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, China Agricultural University, Beijing 100193, China.AbstractThis study was conducted to determine the effects of the antimicrobial peptide cecropin on performance and intestinal health in piglets. Newly weaned barrows were randomly assigned to one of three treatments (n=8), including a corn-soybean basal diet or similar diets supplemented with antibiotics (100 mg/kg kitasamycin plus 800 mg/kg colistin sulfate) or 400 mg/kg cecropin AD. On day 13, all piglets were orally challenged with 10(9)CFU/mL of Escherichia coli K88. On day 19, all piglets were euthanized and sampled. Before challenge, piglets fed antibiotics had greater weight gain, feed efficiency, nitrogen and energy retention than the control (P<0.05). E. coli challenge decreased weight gain, feed intake and feed efficiency for the control piglets (P<0.05) but not for the antibiotic or cecropin AD treated piglets. The incidence of diarrhea post-challenge in the antibiotic and cecropin AD treatments decreased compared with the control piglets. The total viable counts of cecal E. coli were lower while the Lactobacilli counts were higher in the antibiotic and cecropin AD treatments compared with the control (P<0.05). Cecropin AD treatment decreased total aerobes while increasing total anaerobes in the ileum (P<0.05). A higher villus height to crypt depth ratio in the jejunum and ileum as well as a deeper crypt depth in the jejunum and higher villus height in the ileum were observed in piglets fed antibiotics or cecropin AD compared with control piglets (P<0.05). Piglets fed the control diet had lower levels of secretory IgA in their jejunum and lower serum IgA, IgG, interleukin-1β and interleukin-6 compared with the other treatments (P<0.05). Overall, these data suggest that cecropin AD enhances pig performance through increasing immune status and nitrogen and energy retention as well as reducing intestinal pathogens in weaned piglets.
Peptides.Peptides.2012 Jun;35(2):225-30. doi: 10.1016/j.peptides.2012.03.030. Epub 2012 Apr 3.
This study was conducted to determine the effects of the antimicrobial peptide cecropin on performance and intestinal health in piglets. Newly weaned barrows were randomly assigned to one of three treatments (n=8), including a corn-soybean basal diet or similar diets supplemented with antibiotics (1
PMID 22490448

Japanese Journal

高速液体クロマトグラフィー/質量分析法による乳中のマクロライド系抗生物質の定量(<特集>若手研究者の初論文)

竹上晴美,堀江正一,中澤裕之
分析化学 55(9), 651-659, 2006-09-05
高速液体クロマトグラフ/質量分析計(LC/MS)を用いた簡易かつ感度の高い乳中のマクロライド系抗生物質,具体的にはエリスロマシン,オレアンドマイシン,キタサマイシン,ジョサマイシン,ミロサマイシン,ネオスピラマイシン,スピラマイシン,チルミコシン及びタイロシンの同時分析法を検討した.試料の前処理には抽出にアセトニトリルを採用し,ヘキサンによる液液抽出によりクリーンアップを行った.高速液体クロマトグ …
NAID 110004833099

最近分離された Nocardia seriolae の薬剤感受性

板野公一,川上秀昌
魚病研究 37(3), 152-153, 2002-09-15
… Resistance to oxolinic acid and fosfomycin was found in all the isolates and some of the isolates showed resistance to erythromycin, spiramycin and kitasamycin. …
NAID 10019223626

バイオオートグラフィーによるプレミックス中のキタサマイシンの確認試験法

風間鈴子,荒木誠士
飼料研究報告 27, 102-111, 2002-04
NAID 40005509127

Related Pictures

★リンクテーブル★

リンク元	「キタサマイシン」「Leucomycin」
拡張検索	「kitasamycin tartrate」

「キタサマイシン」

Kitasamycin
Systematic (IUPAC) name
	2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	39405-35-1
ATCvet code	QJ01FA93
PubChem	CID 5282189
ChEMBL	CHEMBL1909061
Synonyms	Turimycin
Chemical data
Formula	C35H59NO13
Mol. mass	701.84 g/mol
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