ketolide antibiotic

WordNet

a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs" (同)antibiotic drug
of or relating to antibiotic drugs

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The slow dissociation rate of K-1602 contributes to the enhanced inhibitory activity of this novel alkyl-aryl-bearing fluoroketolide.

Krokidis M1, Bougas A2, Stavropoulou M3, Kalpaxis D2, Dinos GP2.
Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2016 Apr;31(2):276-82. doi: 10.3109/14756366.2015.1018246. Epub 2015 Mar 25.
Ketolides belong to the latest generation of macrolides and are not only effective against macrolide susceptible bacterial strains but also against some macrolide resistant strains. Here we present data providing insights into the mechanism of action of K-1602, a novel alkyl-aryl-bearing fluoroketol
PMID 25807301

Nascent peptide assists the ribosome in recognizing chemically distinct small molecules.

Gupta P1, Liu B2, Klepacki D1, Gupta V1, Schulten K2, Mankin AS1, Vázquez-Laslop N1.
Nature chemical biology.Nat Chem Biol.2016 Jan 4. doi: 10.1038/nchembio.1998. [Epub ahead of print]
Regulation of gene expression in response to the changing environment is critical for cell survival. For instance, binding of macrolide antibiotics to the ribosome promotes translation arrest at the leader open reading frames ermCL and ermBL, which is necessary for inducing the antibiotic resistance
PMID 26727240

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides.

Almutairi MM1, Park SR2, Rose S3, Hansen DA4, Vázquez-Laslop N1, Douthwaite S3, Sherman DH5, Mankin AS6.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Oct 20;112(42):12956-61. doi: 10.1073/pnas.1512090112. Epub 2015 Oct 5.
Ketolides are promising new antimicrobials effective against a broad range of Gram-positive pathogens, in part because of the low propensity of these drugs to trigger the expression of resistance genes. A natural ketolide pikromycin and a related compound methymycin are produced by Streptomyces vene
PMID 26438831

The First Telithromycin-Resistant Streptococus pneumoniae Isolate in Japan Associated with erm(B) and Mutations in 23S rRNA and Riboprotein L4