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English Journal

Xu J, Guo P, Liu C, Sun Z, Gui L, Guo Y, Yamakuni T, Ohizumi Y.SourceCollege of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University.
Bioscience, biotechnology, and biochemistry.Biosci Biotechnol Biochem.2011 Jul 23;75(7):1386-8. Epub 2011 Jul 7.
The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed
PMID 21737919

Anti-neuroinflammatory Activity of Kamebakaurin From Isodon japonicus via Inhibition of c-Jun NH(2)-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Pathway in Activated Microglial Cells.

Kim BW, Koppula S, Kim IS, Lim HW, Hong SM, Han SD, Hwang BY, Choi DK.SourceDepartment of Biotechnology, Konkuk University, Korea.
Journal of pharmacological sciences.J Pharmacol Sci.2011 Jul 15;116(3):296-308. Epub 2011 Jun 25.
Compelling evidence supports the notion that the majority of neurodegenerative diseases are associated with microglia-mediated neuroinflammation. Therefore, quelling of microglial activation may lead to neuronal cell survival. The present study investigated the effects of Kamebakaurin (KMBK), a kaur
PMID 21705843

ent-Kaurane and ent-Pimarane Diterpenes from Siegesbeckia pubescens Inhibit Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglia

Lee Mina,Kim Seung Hyun,Lee Hee Kyoung [他],Cho Yekyung,Kang Jimmy,Sung Sang Hyun
Biological and Pharmaceutical Bulletin 37(1), 152-157, 2014
… Several steps of chromatography yielded eight ent-kaurane diterpenes (1–8) and one ent-pimarane diterpene (9) from the 90% MeOH fraction. … These results suggest that ent-kaurane and ent-pimarane diterpenes isolated from S. …
NAID 130003382091

Xu Jing,Guo Ping,Liu Cuizhou [他],SUN Zhanping,GUI Liping,GUO Yuanqiang,YAMAKUNI Tohru,OHIZUMI Yasushi
Bioscience, biotechnology, and biochemistry 75(7), 1386-1388, 2011-07-23
… The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. …
NAID 10029329566

Anti-neuroinflammatory Activity of Kamebakaurin From Isodon japonicus via Inhibition of c-Jun NH_2-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Pathway in Activated Microglial Cells

Kim Byung-Wook,Koppula Sushruta,Kim In Su [他],LIM Hyung-Woo,HONG Sun-Min,HAN Sang-Don,HWANG Bang-Yeon,CHOI Dong-Kug
Journal of pharmacological sciences 116(3), 296-308, 2011-07-20
… The present study investigated the effects of Kamebakaurin (KMBK), a kaurane diterpene isolated from Isodon japonicus …
NAID 10029895231