核融解

WordNet

disintegration and dissolution of a cell nucleus when a cell dies

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/18 23:32:32」(JST)

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Morphological characteristics of karyolysis and other forms of nuclear destruction.

Karyolysis (from Greek κάρυον karyon, "kernel, seed or nucleus", and λύσις lysis from λύειν lyein, "to separate") is the complete dissolution of the chromatin of a dying cell due to the enzymatic degradation by endonucleases. The whole cell will eventually stain uniformly with eosin after karyolysis. It is usually associated with karyorrhexis and occurs mainly as a result of necrosis, while in apoptosis after karyorrhexis the nucleus usually dissolves into apoptotic bodies.^[1]

Additional images

Micrograph showing karyolysis and contraction band necrosis in an individual that had a myocardial infarction (heart attack).
Micrograph showing karyolysis and contraction band necrosis (left of image) and ischemic (nucleated) cardiac myocytes (right of image) in an individual that had a myocardial infarction.

References

^ Cotran; Kumar, Collins (1998). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.

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English Journal

Bio-monitoring for the genotoxic assessment in road construction workers as determined by the buccal micronucleus cytome assay.

Celik A, Yildirim S, Ekinci SY, Taşdelen B.SourceMersin University, Faculty of Science and Letters, Department of Biology, 33343 Mersin, Turkey. Electronic address: aylace67@gmail.com.
Ecotoxicology and environmental safety.Ecotoxicol Environ Saf.2013 Mar 5. pii: S0147-6513(13)00048-1. doi: 10.1016/j.ecoenv.2013.01.030. [Epub ahead of print]
Buccal micronucleus cytome (BMCyt) assay monitors genetic damage, cell proliferation and cell death in humans exposed to occupational and environmental agents. BMCyt is used as an indicator of genotoxic exposure, since it is associated with chromosomal instability. There is little research on the oc
PMID 23474067

Induction of nuclear anomalies in exfoliated buccal cells of coca chewers: results of a field study.

Nersesyan A, Kundi M, Krupitza G, Barcelos G, Mišík M, Wultsch G, Carrion J, Carrion-Carrera G, Knasmueller S.SourceDepartment of Internal Medicine 1, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8A, 1090, Vienna, Austria.
Archives of toxicology.Arch Toxicol.2013 Mar;87(3):529-34. doi: 10.1007/s00204-012-0969-1. Epub 2012 Nov 6.
The leaves of coca (Erythroxylum coca var. coca), a South American shrub which contains cocaine, other alkaloids and phenolics are widely used by indigenous populations of the Andes. It is currently not known if coca consumption causes genotoxic effects in humans. This information is important to pr
PMID 23128829

Genotoxicity in gingival cells of patients undergoing tooth restoration with two different dental composite materials.

Tadin A, Galic N, Mladinic M, Marovic D, Kovacic I, Zeljezic D.SourceStudy of Dental Medicine, School of Medicine, University of Split, Soltanska 2, 21 000, Split, Croatia, atadin@mefst.hr.
Clinical oral investigations.Clin Oral Investig.2013 Feb 5. [Epub ahead of print]
OBJECTIVES: Dental composite materials come into direct contact with oral tissue, especially gingival cells. This study was performed to evaluate possible DNA damage to gingival cells exposed to resin composite dental materials.MATERIALS AND METHODS: Class V restorations were placed in 30 adult pati
PMID 23385426

Japanese Journal

Abnormal Expression of 8-Nitroguanine in the Brain of Mice Exposed to Arsenic Subchronically

PIAO Fengyuan,LI Sheng,LI Qiujuan,YE Jianxin,LIU Shuang
Industrial Health 49(2), 151-157, 2011
… Nervous cells in the brain of mice exposed to As showed disappearances of axons, vacuolar degeneration in cytoplasm and karyolysis, whereas no such pathological changes were observed in the control group. …
NAID 130004828602

Relative Biological Effectiveness of Carbon Ions for Causing Fatal Liver Failure after Partial Hepatectomy in Mice

Tomizawa Minoru,Miyamoto Tadaaki,Kato Hirotoshi [他],OTSU HIROSHI
Journal of radiation research 41(2), 151-161, 2000-06
… Hepatocytes showed karyorrhexis and karyolysis in carbon ion irradiated and spotty necrosis in X-ray irradiated mice, suggesting nuclear damage. …
NAID 110002328805

ガンマ線照射によるウリミバエ雌の不妊化機構の超微形態学的観察

桜井宏紀,田畑幸司,照屋匡,小濱継雄
岐阜大学農学部研究報告 61, 31-38, 1996-11-28
ガンマ線照射によるウリミバエ(Dacus cucurbitae Coquillett)雌の不妊化機構を解明するため,卵形成と中腸に及ぼすガンマ線照射の影響を超微形態学的に検討した。正常虫では羽化後直ちに第1卵胞が交互栄養室型卵管の生殖巣より分化した。栄養細胞と濾胞上皮細胞は卵母細胞の成長に関連した形態学的変化を示し,羽化後8日以降に成熟卵が形成された。一方,照射虫の卵巣小管では卵原細胞は核濃縮や核 …
NAID 110001000875