junctophilin

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Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress.

Li S1, Zhang L1, Ni R2, Cao T1, Zheng D3, Xiong S1, Greer PA4, Fan GC5, Peng T6.
Biochimica et biophysica acta.Biochim Biophys Acta.2016 Nov;1862(11):2023-2033. doi: 10.1016/j.bbadis.2016.08.005. Epub 2016 Aug 12.
Diabetes and obesity are prevalent in westernized countries. In both conditions, excessive fatty acid uptake by cardiomyocytes induces cardiac lipotoxicity, an important mechanism contributing to diabetic cardiomyopathy. This study investigated the effect of calpain disruption on cardiac lipotoxicit
PMID 27523632

Striated Muscle Preferentially Expressed Protein Kinase (SPEG) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.

Quick AP1, Wang Q1, Philippen LE1, Barreto-Torres G1, Chiang DY2, Beavers DL1, Wang G3, Khalid M4, Reynolds JO1, Campbell HM1, Showell J1, McCauley MD5, Scholten A6, Wehrens XH7.
Circulation research.Circ Res.2016 Oct 11. pii: CIRCRESAHA.116.309977. [Epub ahead of print]
RATIONALE: Junctional membrane complexes (JMC) in myocytes are critical microdomains, in which excitation-contraction coupling occurs. Structural and functional disruption of JMCs underlies contractile dysfunction in failing hearts. However, the role of newly identified JMC protein striated muscle p
PMID 27729468

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release.

Reynolds JO1, Quick AP1, Wang Q1, Beavers DL2, Philippen LE1, Showell J1, Barreto-Torres G1, Thuerauf DJ3, Doroudgar S4, Glembotski CC3, Wehrens XH5.
International journal of cardiology.Int J Cardiol.2016 Oct 8;225:371-380. doi: 10.1016/j.ijcard.2016.10.021. [Epub ahead of print]
BACKGROUND: Junctophilin-2 (JPH2) is the primary structural protein for the coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 ryanodine receptors on the sarcoplasmic reticulum within junctional membrane complexes (JMCs) in cardiomyocytes. Effective signaling between
PMID 27760414