関: isopropamide

WordNet

a salt or ester of hydriodic acid

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ヨウ化物

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/23 15:04:57」(JST)

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Isopropamide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.

References

Seeherman R, Isopropamide iodide: a long-acting anticholinergic, Del Med J. 1957 Oct;29(10):265-9.
Boss EG Jr, Buchanan GC, Effect of isopropamide iodide on basal gastric secretion in the human, Gastroenterology. 1957 Nov;33(5):730-6.

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English Journal

Spectrophotometric determination of isopropamide iodide and trifluoperazine hydrochloride in presence of trifluoperazine oxidative degradate.

Abbas SS1, Zaazaa HE, Abdelkawy M, Abdelrahman MM.Author information 1Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., 11562 Cairo, Egypt.AbstractFour sensitive, selective and precise stability indicating methods for the determination of isopropamide iodide (ISO) and trifluoperazine hydrochloride (TPZ) in their binary mixture and in presence of trifluoperazine oxidative degradate (OXD). Method A is a derivative spectrophotometric one, where ISO was determined by first derivative (D(1)) at 226.4 nm while TPZ was determined by second derivative (D(2)) at 270.2 nm. Method B is the first derivative of the ratio spectra (DD(1)) spectrophotometric method, ISO can be determined by measuring the peak amplitude at 227.4 nm using 5 microg mL(-1) of OXD as a divisor, while TPZ can be determined by measuring the peak amplitude at 249.2 and 261.4 nm using 15 microg mL(-1) of ISO as a divisor. Method C is the isoabsorptive spectrophotometric method. This method allows determination of ISO and TPZ in their binary mixture by measuring total concentration of ISO and TPZ at their isoabsorptive point at lambda(229.8) nm (Aiso1) while TPZ concentration alone can be determined at lambda(max) 311.2 nm, then ISO concentration can be determined by subtraction. On the same basis TPZ can be determined in presence of ISO and OXD, where OXD concentration alone was determined by measuring the peak amplitude at lambda(281.6) and lambda(309.4) nm while total concentration of TPZ and OXD was determined at their isoabsorptive points at (Aiso2 = 270.2 nm), (Aiso3 = 310.6 nm) and (Aiso4 = 331.8 nm) then TPZ concentration was determined by subtraction. Method D is the multivariate calibration techniques [the classical least squares (CLS), principal component regression (PCR) and partial least squares (PLS)], using the information contained in the absorption spectra of ISO, TPZ and OXD mixtures. The selectivity of the proposed methods was checked using laboratory prepared mixtures. The proposed methods have been successfully applied to the analysis of ISO and TPZ in pharmaceutical dosage form without interference from other dosage form additives and the results were statistically compared with the reported method.
Drug testing and analysis.Drug Test Anal.2010 Apr;2(4):168-81. doi: 10.1002/dta.113.
Four sensitive, selective and precise stability indicating methods for the determination of isopropamide iodide (ISO) and trifluoperazine hydrochloride (TPZ) in their binary mixture and in presence of trifluoperazine oxidative degradate (OXD). Method A is a derivative spectrophotometric one, where I
PMID 20376832

Derivative spectrophotometric, thin layer chromatographic-densitometric and high performance liquid chromatographic determination of trifluoperazine hydrochloride in presence of its hydrogen peroxide induced-degradation product.

El-Gindy A1, El-Zeany B, Awad T, Shabana MM.Author information 1Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, 41522, Ismailia, Egypt. ghada74@ismailia.ie-eg.comAbstractThree methods are presented for the determination of trifluoperazine HCl in presence of its hydrogen peroxide induced degradation product. The first method was based on measurement of first (1D) and second (2D) derivative amplitudes of trifluoperazine HCl in 0.1 N hydrochloric acid at the zero crossing point of its sulfoxide derivative, main degradation product, (at 268.4 and 262.5 nm for 1D and 2D, respectively). The second method was based on the separation of trifluoperazine HCl from its sulfoxide derivative followed by densitometric measurement of the intact drug spot at 255 nm. The separation was carried out on Merck aluminum sheet of silica gel 60 F(254), using chloroform-methanol (7:3 v/v) as mobile phase. The third method was based on high performance liquid chromatographic separation of trifluoperazine HCl from its sulfoxide derivative on reversed phase, ODS column, using a mobile phase of acetonitrile-phosphate buffer pH 4.2 (60:40 v/v) at ambient temperature. Quantitation was achieved with UV detection at 255 nm based on peak area. The first derivative spectrophotometric method was utilized to investigate the kinetics of the hydrogen peroxide degradation process at different temperatures. The apparent pseudo first-order rate constant, half life and activation energy were calculated.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2002 Jan 1;27(1-2):9-18.
Three methods are presented for the determination of trifluoperazine HCl in presence of its hydrogen peroxide induced degradation product. The first method was based on measurement of first (1D) and second (2D) derivative amplitudes of trifluoperazine HCl in 0.1 N hydrochloric acid at the zero cross
PMID 11682205

Spectrophotometric determination of trifluoperazine HCl and isopropamide iodide in binary mixture using second derivative and second derivative of the ratio spectra methods.

El-Gindy A1, El-Zeany B, Awad T, Shabana MM.Author information 1Faculty of Pharmacy, Pharmaceutical Analytical Chemistry Department, Suez Canal University, Ismailia 41522, Egypt. ghada74@ismailia.ie-eg.comAbstractTwo methods are presented for the simultaneous determination of trifluoperazine hydrochloride and isopropamide iodide in binary mixture. The first method depends on second derivative ((2)D) ultraviolet spectrophotometry, with zero crossing and peak to base measurement. The second derivative amplitudes at 270.4 and 230.2 nm were selected for the assay of trifluoperazine hydrochloride and isopropamide iodide, respectively. The second method depends on second derivative of the ratio spectra by division of the absorption spectrum of the binary mixture by a normalized spectrum of one of the components and then calculating the second derivative of the ratio spectrum. The second derivative of the ratio amplitudes at 257 and 228 nm were selected for the determination of trifluoperazine hydrochloride and isopropamide iodide, respectively. The two proposed methods were successfully applied to the determination of the two drugs in laboratory prepared mixtures and in commercial tablets.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2001 Sep;26(2):203-10.
Two methods are presented for the simultaneous determination of trifluoperazine hydrochloride and isopropamide iodide in binary mixture. The first method depends on second derivative ((2)D) ultraviolet spectrophotometry, with zero crossing and peak to base measurement. The second derivative amplitud
PMID 11470197

Japanese Journal

Isopropamide Iodideのラット胃腸管吸収におよぼすトリクロロ酢酸の併用効果

後藤茂,吉富博則,福池厚子
藥學雜誌 97(8), 867-872, 1977-08-25
… Pharmacological response and diameter of a pupil in the rat were examined after oral administration of isopropamide iodide when given in combination with 50-fold molar excess of trichloroacetate in solution and compared with those after single administration of isopropamide iodide. …
NAID 110003661247

胃内容排出におよぼす4級アンモニウム塩の影響

後藤茂,吉富博則,藤井勝蔵
藥學雜誌 97(7), 801-804, 1977-07-25
… On the other hand, when these quaternary ammonium salts were administered subcutaneously, a retardation of stomach emptying rate was observed thirty minutes after oral administration of phenol red and its extent was given in the following order, isopropamide iodie>benzilonium bromide>benactyzine methobromide=anisotropine methobromide>propantheline bromide. …
NAID 110003652607

「イソプロパミド」

Isopropamide
Systematic (IUPAC) name
	4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium
Clinical data
MedlinePlus	a694006
Pregnancy cat.	?
Legal status	Rx-only, Unscheduled (US) Unscheduled
Routes	Oral
Identifiers
CAS number	7492-32-2
ATC code	A03AB09
PubChem	CID 3775
DrugBank	DB01625
ChemSpider	3643
UNII	8B9I31H724
ChEMBL	CHEMBL1201232
Chemical data
Formula	C23H33N2O1 +
Mol. mass	353.52092 g/mol
	SMILES O=C(N)C(c1ccccc1)(c2ccccc2)CC[N+](C(C)C)(C(C)C)C;
	InChI InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1 ; Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O ;
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　　[★]

英: isopropamide、isopropamide iodide
関: ヨウ化イソプロパミド

「ヨウ化イソプロパミド」

　　[★]

英: isopropamide iodide
関: イソプロパミド

「iodide」

　　[★]

n.

ヨウ化物、ヨウ化

adj.

ヨウ素の

関: I、I2、iodine、iodo

「isopropamide」

　　[★]

イソプロパミド

関: isopropamide iodide

リンク元	「イソプロパミド」「ヨウ化イソプロパミド」
関連記事	「iodide」「isopropamide」

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案内

案内

isopropamide iodide