WordNet

change into an isomer (同)isomerise
cause to change into an isomer (同)isomerise
the conversion of a compound into an isomer of itself (同)isomerisation

English Journal

Pin1 and nuclear receptors: A new language?

La Montagna R, Caligiuri I, Giordano A, Rizzolio F.SourceSbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA; Human Health Foundation, Terni and Spoleto (PG), Italy.
Journal of cellular physiology.J Cell Physiol.2012 Dec 31. doi: 10.1002/jcp.24316. [Epub ahead of print]
Pin1 is a unique enzyme that can isomerize specific phospho-Ser/Thr-Pro peptide bonds, inducing a conformational change in the target protein. Such activity represents a novel and tightly controlled signaling mechanism regulating a spectrum of protein functions during the normal physiology of the ce
PMID 23280577

Cytotoxicity and Fluorescence Visualization of Ergot Alkaloids in Human Cell Lines.

Mulac D, Lepski S, Ebert F, Schwerdtle T, Humpf HU.AbstractThe ergot alkaloids as secondary metabolites from fungi of the species Claviceps are in the focus of many investigations due to their pharmacological and toxicological properties. The main effects of ergot alkaloids are referred to an interaction with several receptor systems in the human body. It is well known that ergot alkaloids are able to isomerize with one isomer being biologically active and one being only weakly active, whereas the activity is restricted to receptor interactions. Latest investigations have proven that ergot alkaloids also show cytotoxic effects and induce apoptosis in human primary cells. These effects seem to correlate with accumulation properties. It was the aim of our current study to determine such effects in cancer cell lines, as ergot derivatives are also used in tumor therapy. Our results confirm the apoptotic effects in two cancer cell lines (HepG2, HT 29) in a high range and accumulation measurements show an important correlation between alkaloid concentration in cell lysate of the receptor inactive isomers and cytotoxicity. In addition the strong accumulative effects were firstly visualized by fluorescence microscopy by taking advantage of the natural fluorescence properties of ergot alkaloids.
Journal of agricultural and food chemistry.J Agric Food Chem.2012 Dec 20. [Epub ahead of print]
The ergot alkaloids as secondary metabolites from fungi of the species Claviceps are in the focus of many investigations due to their pharmacological and toxicological properties. The main effects of ergot alkaloids are referred to an interaction with several receptor systems in the human body. It i
PMID 23256872

Atmospheric Oxidation Mechanism of 2,7-Dimethylnaphthalene is Different from That of Monocyclic Aromatic Benzenes. A Theoretical Study.

Zhang Z, Xu X, Wang L.SourceSchool of Materials Science & Engineering and ‡School of Chemistry & Chemical Engineering, South China University of Technology , Guangzhou 510640, China.
The journal of physical chemistry. A.J Phys Chem A.2012 Dec 19. [Epub ahead of print]
The atmospheric oxidation mechanism of 2,7-dimethylnaphthalene (27DMN) initiated by OH radical is investigated at levels of BB1K and G3MP2-RAD//BH&HLYP. The reaction is mainly initiated by OH addition to the C(1) position to form radical adduct R1. In the atmosphere, R1 reacts with O(2) via two
PMID 23215026

Japanese Journal

Abnormal Protein Aggregation Due to the Presence of D-Aspartyl Residues in Cataractous Lenses

Fujii Noriko,Fujii Norihiko,Sugiyama Masaaki
Transactions of the Materials Research Society of Japan 37(2), 131-134, 2012
… Here we describe three important aspects of our research: (i) a method for detecting D-β-Asp at specific sites in particular proteins, (ii) a likely spontaneous mechanism by which Asp residues in proteins invert and isomerize to the D-β-form, (iii) a discussion of factors that favor such a reaction. …
NAID 130003399066

アリールチオ基を有するテトラヘドランの合成及び反応性

落合達海,中本真晃,関口章
基礎有機化学討論会要旨集（基礎有機化学連合討論会予稿集） 2010(0), 2P19-2P19, 2011
テトラヘドラニルリチウムを前駆体として、初めて硫黄置換テトラヘドランの合成に成功した。化合物は、NMR、紫外可視吸収スペクトル、X線結晶構造解析により同定した。また、4-nitrophenyl tetrahedranyl sulfide は光照射によりシクロブタジエンに異性化し、熱反応では2分子のアセチレンに分解することを明らかにした。
NAID 130004729157

アシロイン水素移動反応の速度論的研究

窪内大輝,狩野真啓,山高博
基礎有機化学討論会要旨集（基礎有機化学連合討論会予稿集） 2011(0), 317-317, 2011
反応基質の化学変化と溶媒和-脱溶媒和がどのようなタイミングで起こるのかという問題は有機反応において大変重要である。この問題の解明に向けてアシロインの水素移動反応を取り上げた。アシロインは酸性、塩基性条件で分子内水素移動を起こすことが予想される。これらの条件におけるアシロイン誘導体の水素移動反応について反応速度や平衡定数を測定し、速度論的解析を行った。
NAID 130004645831