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Dreier JP, Drenckhahn C, Woitzik J, Major S, Offenhauser N, Weber-Carstens S, Wolf S, Strong AJ, Vajkoczy P, Hartings JA; For the COSBID Study Group.SourceCenter for Stroke Research Berlin, Campus Charité Mitte, Charité University Medicine Berlin, Charitéplatz 1, Berlin, 10117, Germany, jens.dreier@charite.de.
Acta neurochirurgica. Supplement.Acta Neurochir Suppl.2013;115:125-129.
Spreading depolarization (SD) is a wave of mass neuronal and glial depolarization associated with net influx of cations and water. Prolonged SDs facilitate neuronal death. SD induces tone alterations in cerebral resistance arterioles, leading to either transient hyperperfusion (physiological neurova
PMID 22890658

Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke.

He S, Wang C, Dong H, Xia F, Zhou H, Jiang X, Pei C, Ren H, Li H, Li R, Xu H.SourceDepartment of Immunology; Harbin Medical University; Harbin, China.
Autophagy.Autophagy.2012 Nov 1;8(11). [Epub ahead of print]
Autophagy is an important cellular recycling mechanism through self-digestion in responses to cellular stress such as starvation. Studies have shown that autophagy is involved in maintaining the homeostasis of neural system during stroke. However, molecular mechanisms underlying neuronal autophagy i
PMID 22874556

Chronic treatment with a water-soluble extract from the culture medium of Ganoderma lucidum mycelia (MAK) prevents apoptosis and necroptosis in hypoxia/ischemia-induced injury of type 2 diabetic mouse brain

玄美燕,岡﨑真理,岩田直洋,浅野哲,神内伸也,松崎広和,坂本武史,Miyano Yoshiyuki,飯塚博,日比野康英
Evidence-based complementary and alternative medicine 2015(865986), 1-29, 2015-02-03
… Type 2 diabetes mellitus has been known to increase systemic oxidative stress by chronic hyperglycemia and visceral obesity and aggravate cerebral ischemic injury. … Histochemical analysis showed that MAK significantly suppressed superoxide production, neuronal cell death, and vacuolation in the ischemic penumbra, which was accompanied by a decrease in the numbers of TUNEL- or cleaved caspase-3-positive cells. …
NAID 120005590299

祖母井龍,須山武裕,下里倫,松田康,富永良子,村上昌宏,乾敏彦,山里景祥,北野昌彦,長谷川洋,富永紳介
脳神経血管内治療 advpub(0), 2015
… 動脈閉塞による急性期脳梗塞に対しPenumbra system による血行再建と頚動脈ステントの併用により良好な経過を得た2 症例を経験したので報告する．【症例1】72 歳男性．左片麻痺を主訴に当院に搬送された．脳血管撮影の所見から，右内頚動脈起始部高度狭窄に由来するアテローム血栓性塞栓により内頚動脈閉塞に至った脳梗塞と診断し，まず内頚動脈の血栓をPenumbra system で回収した．遠位塞栓をきた …
NAID 130005066500