イオトロラン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/23 12:26:57」(JST)
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Iotrolan
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Systematic (IUPAC) name |
2,4,6-triiodo-5-{N-methyl-2-[methyl({2,4,6-triiodo-3,5-bis[(1,3,4-trihydroxybutan-2-yl)carbamoyl]phenyl})carbamoyl]acetamido}-1-N,3-N-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy |
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Legal status |
Legal status |
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Identifiers |
CASRN |
79770-24-4 Y |
ATC code |
V08AB06 (WHO) |
PubChem |
CID 3738 |
UNII |
16FL47B687 N |
KEGG |
D01714 Y |
ChEMBL |
CHEMBL1200555 N |
Chemical data |
Formula |
C37H48I6N6O18 |
Molar mass |
1626.23 g/mol |
NY (what is this?) (verify) |
Iotrolan (trade name Isovist) is a radiocontrast agent, a substance used to improve the visibility of body structures on images obtained by X-ray techniques. It is particularly used to image spaces surrounding the central nervous system, such as the ventricles, after injection into the cerebrospinal fluid.[1] It can also be used to image joint spaces and in endoscopic retrograde cholangiopancreatography (ERCP).[citation needed]
Chemically, the substance is a dimer of triiodinated isophthalic acid derivatives.
References
Contrast media (V08)
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X-ray and CT |
Iodinated,
Water soluble
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Nephrotropic,
high osmolar
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- Diatrizoic acid#
- Metrizoic acid
- Iodamide
- Iotalamic acid
- Ioxitalamic acid
- Ioglicic acid
- Acetrizoic acid
- Iocarmic acid
- Methiodal
- Diodone
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Nephrotropic,
low osmolar
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- Metrizamide
- Iohexol#
- Ioxaglic acid
- Iopamidol
- Iopromide
- Iotrolan
- Ioversol
- Iopentol
- Iodixanol
- Iomeprol
- Iobitridol
- Ioxilan
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Hepatotropic
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- Iodoxamic acid
- Iotroxic acid
- Ioglycamic acid
- Adipiodone
- Iobenzamic acid
- Iopanoic acid
- Iocetamic acid
- Sodium iopodate
- Tyropanoic acid
- Calcium iopodate
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Iodinated,
Water insoluble
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- Ethyl esters of iodised fatty acids
- Iopydol
- Propyliodone
- Iofendylate
- Lipiodol
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Non-iodinated
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MRI |
Paramagnetic
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- Gadolinium-based: Gadobenic acid
- Gadobutrol
- Gadodiamide
- Gadofosveset
- Gadolinium
- Gadopentetic acid
- Gadoteric acid
- Gadoteridol
- Gadoversetamide
- Gadoxetic acid
Other: Ferric ammonium citrate
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Superparamagnetic
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- Ferumoxsil
- Ferristene
- Iron oxide, nanoparticles
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Other
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Ultrasound |
- Microspheres of human albumin
- Microparticles of galactose
- Perflenapent
- Microspheres of phospholipids
- Sulfur hexafluoride
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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English Journal
- Adverse skin reactions to iodinated x-ray contrast agents in healthy rats.
- Lenhard DC1, May E, Morgenroth C, Jost G, Haider W, Pietsch H.
- Investigative radiology.Invest Radiol.2014 Dec;49(12):779-87. doi: 10.1097/RLI.0000000000000084.
- PURPOSE: The aim of this preclinical study on healthy Sprague-Dawley rats was to determine whether differences exist in the induction of adverse skin reactions after the intravenous administration of a monomeric and 2 dimeric iodinated nonionic contrast agents.MATERIALS AND METHODS: After intravenou
- PMID 24988006
- Cytotoxic effects of the radiocontrast agent iotrolan and anesthetic agents bupivacaine and lidocaine in three-dimensional cultures of human intervertebral disc nucleus pulposus cells: identification of the apoptotic pathways.
- Iwasaki K1, Sudo H2, Yamada K1, Ito M2, Iwasaki N1.
- PloS one.PLoS One.2014 Mar 18;9(3):e92442. doi: 10.1371/journal.pone.0092442. eCollection 2014.
- BACKGROUND: Discography and discoblock are imaging procedures used to diagnose discogenic low back pain. Although needle puncture of the intervertebral disc (IVD) itself induces disc degeneration, the agents used in these procedures may also have harmful effects on IVD cells. The purpose of this stu
- PMID 24642945
- Pilot study on basophil activation induced by contrast medium.
- Böhm I1, Speck U, Schild HH.
- Fundamental & clinical pharmacology.Fundam Clin Pharmacol.2011 Apr;25(2):267-76. doi: 10.1111/j.1472-8206.2010.00826.x.
- The purpose was to analyze the influence of both mono-/dimeric X-ray contrast media (CM) and immunological co-factors on basophil degranulation. The study has been conducted in 31 adult patients who received nonionic CM injection for enhanced routine computed tomography examination. Plasma histamine
- PMID 20412314
Japanese Journal
- Cytotoxic Effects of the Radiocontrast Agent Iotrolan and Anesthetic Agents Bupivacaine and Lidocaine in Three-Dimensional Cultures of Human Intervertebral Disc Nucleus Pulposus Cells: Identification of the Apoptotic Pathways
- Iwasaki Koji,Sudo Hideki,Yamada Katsuhisa,Ito Manabu,Iwasaki Norimasa
- PLOS ONE 9(3), e92442, 2014-03-18
- … Methods: Healthy human NP cells were cultured for 7 days in three-dimensional (3D) cell-alginate bead composites, and were then exposed to clinically relevant doses of a radiocontrast agent (iotrolan) or local anesthetic (lidocaine or bupivacaine). … Results: The radiocontrast agent iotrolan did not affect NP cell viability or induce apoptosis. … Conclusions/Significance: The present study demonstrates that iotrolan does not affect the viability of healthy human NP cells. …
- NAID 120005434500
- 犬における脊髄造影での造影効果の違い : イオヘキソール(180mgI/ml),イオヘキソール(240mgI/ml)およびイオトロラン(240mgI/ml)の比較(外科学)
- 清水 純一郎,山田 一孝,岸本 海織 [他],岩崎 利郎,三宅 陽一
- The journal of veterinary medical science 70(7), 659-663, 2008-07-25
- 3種類の造影剤製剤(イオヘキソール180mgI/ml,イオヘキソール240mgI/mlおよびイオトロラン240mgI/ml)におけるConventionalおよびCT Myelographyの造影効果を比較した.ビーグル犬3頭を用いて各造影剤製剤についてそれぞれ3頭のクロスオーバー(のべ9頭)により実験を行った. CT Myelographyの評価では注入5分後では,尾側は粘稠度の高いイオトロラン …
- NAID 110006839585
- 横山 正尚
- 日本臨床麻酔学会誌 25(1), 71-80, 2005
- 硬膜外ブロックの無痛域が硬膜外造影で予測できるかを90例の患者で調べた. 無痛域は1.5%リドカインを5ml注入, 硬膜外造影はイオトロラン240mgI・ml -1 を5ml注入して調べた. 患者をカテーテル先端の位置により3群 (C群: C-T4, T群: T5-T10, L群: T11-L) に分け, 広がりのパターンを比較した. 硬膜外造影は無痛域とよく相関した (右側: Y=0.81X …
- NAID 130004449489
Related Links
- 非イオン性ダイマー型造影剤 (Iotrolan) の血管透過性及び血流動態に関する実験的検討-dynamic CT及び血管造影における ... Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed.
- Definition of iotrolan in the Medical Dictionary. iotrolan explanation. Information about iotrolan in Free online English dictionary. What is iotrolan? Meaning of iotrolan medical term. What does iotrolan mean? iotrolan - definition of ...
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