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- intrathymically
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English Journal
- Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy.
- Tuckett AZ1, Thornton RH, Shono Y, Smith OM, Levy ER, Kreines FM, van den Brink MR, Zakrzewski JL.
- Blood.Blood.2014 May 1;123(18):2797-805. doi: 10.1182/blood-2013-10-535401. Epub 2014 Mar 20.
- T-cell deficiency related to disease, medical treatment, or aging represents a major clinical challenge and is associated with significant morbidity and mortality in cancer and bone marrow transplantation recipients. This study describes several innovative and clinically relevant strategies to manip
- PMID 24652996
- CCR7-mediated migration in the thymus controls γδ T-cell development.
- Reinhardt A1, Ravens S, Fleige H, Haas JD, Oberdörfer L, Lyszkiewicz M, Förster R, Prinz I.
- European journal of immunology.Eur J Immunol.2014 May;44(5):1320-9. doi: 10.1002/eji.201344330. Epub 2014 Mar 7.
- αβ T-cell development and selection proceed while thymocytes successively migrate through distinct regions of the thymus. For γδ T cells, the interplay of intrathymic migration and cell differentiation is less well understood. Here, we crossed C-C chemokine receptor (CCR)7-deficient (Ccr7(-/-) )
- PMID 24500801
- An overview of the intrathymic intricacies of T cell development.
- Shah DK1, Zúñiga-Pflücker JC.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 May 1;192(9):4017-23. doi: 10.4049/jimmunol.1302259.
- The generation of a functional and diverse repertoire of T cells occurs in the thymus from precursors arriving from the bone marrow. In this article, we introduce the various stages of mouse thymocyte development and highlight recent work using various in vivo, and, where appropriate, in vitro model
- PMID 24748636
Japanese Journal
- Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpα + dendritic cells: A murine model
- Baba Tomohisa,Badr M.E.S.,Tomaru Utano,Ishizu Akihiro,Mukaida Naofumi
- PLoS ONE 7(7), e41154, 2012-07-16
- … However, it remains elusive on the precise cellular mechanism of intrathymic immune tolerance against tumor antigens. … Finally, intrathymic negative selection similarly ensued in CCR2-competent mice once the tumor-specific antigen was secreted into bloodstream. … Thus, we demonstrated that thymic Sirpα + cDCs crucially contribute to this novel process of intrathymic tumor immune tolerance. …
- NAID 120004419373
- ナチュラルキラーT(natural killer T: NKT)細胞の分化と機能(前編)
- Hyperparathyroidism due to Eutopic PTH Secretion from an Ectopic Intrathymic Parathyroid Cyst
- HOI Wai Han,LEOW Melvin Khee-Shing,SULE Ashish,LEE Hwei Yee,AGASTHIAN T,TAY Jam Chin
- Annals of thoracic and cardiovascular surgery 17(5), 511-513, 2011-10-01
- … Histology confirmed an intrathymic parathyroid cyst. …
- NAID 10030235278
Related Links
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- intrathymic、intrathymically
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- intrathymic