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English Journal
- Characterization of the excited states of DNA building blocks: a coupled cluster computational study.
- Benda Z1, Szalay PG.
- Physical chemistry chemical physics : PCCP.Phys Chem Chem Phys.2016 Sep 14;18(34):23596-606. doi: 10.1039/c6cp02969h. Epub 2016 Aug 10.
- DNA building blocks consisting of up to four nucleobases are investigated using the EOM-CCSD and CC2-LR methods in two B-DNA-like arrangements of a poly-adenine:poly-thymine (poly-A:poly-T) system. Excitation energies and oscillator strengths are presented and the characteristics of the excited stat
- PMID 27506397
- Preparation of Intrastrand {G}O(6) -Alkylene-O(6) {G} Cross-Linked Oligonucleotides.
- O'Flaherty DK1, Wilds CJ1.
- Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.].Curr Protoc Nucleic Acid Chem.2016 Sep 1;66:5.17.1-5.17.24. doi: 10.1002/cpnc.14.
- This unit describes the preparation O(6) -2'-deoxyguanosine-butylene-O(6) -2'-deoxyguanosine dimer phosphoramidites and precursors for incorporation of site-specific intrastrand cross-links (IaCL) into DNA oligonucleotides. Protected 2'-deoxyguanosine dimers are produced using the Mitsunobu reaction
- PMID 27584704
- Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival.
- Dai CH1, Chen P2, Li J2, Lan T3, Chen YC3, Qian H3, Chen K2, Li MY2.
- Oncotarget.Oncotarget.2016 Aug 11. doi: 10.18632/oncotarget.11214. [Epub ahead of print]
- Cisplatin exert its anticancer effect by creating intrastrand and interstrand DNA cross-links which block DNA replication and is a major drug used to treat lung cancer. However, the main obstacle of the efficacy of treatment is drug resistance. Here, we show that expression of translesion synthesis
- PMID 27533083
Japanese Journal
- In vivo制がん活性を有するアゾラト架橋白金(Ⅱ)二核錯体の創薬研究
- 米田 誠治
- 薬学雑誌 132(3), 253-259, 2012
- … Therefore, we synthesized a series of azolato-bridged dinuclear Pt(II) complexes with a general formula, [{cis-Pt(NH3)2}2(μ-OH)(μ-azolato)]2+, which can form 1,2-intrastrand crosslinks with a minimal DNA distortion, whereas clinical platinum-based drugs provide 1,2-intrastrand crosslink with severe DNA distortion. …
- NAID 130001872018
- Cross-Link Dimer Formation of the Acetaldehyde-Derived Cyclic 1,N2-Propano-2'-deoxyguanosine Adduct Using Electrochemical Oxidation
- Murakami Hiroya,Esaka Yukihiro,Uno Bunji
- Chemical and Pharmaceutical Bulletin 57(12), 1434-1436, 2009
- … The dimer has been deduced to be an intrastrand cross-link generated specifically in the G–G sequence in duplex DNA, which is expected to contribute to acetaldehyde-mediated genotoxicity. …
- NAID 130000124551
- Mutation Spectra in Cisplatin- and Transplatin-treated GDL1 Cells Clarified the Different Mode of Action of These Compounds in Mammalian Cells
- Takeiri Akira,Mishima Masayuki,Tanaka Kenji [他],Shioda Akifumi,Harada Asako,Masumura Ken-ichi,Nohmi Takehiko
- 環境変異原研究 = Genes and environment : the official journal of the Japanese Environmental Mutagen Society 29(3), 89-99, 2007-08-31
- … These findings are consistent with previous reports using cell-free systems that cisplatin induces intrastrand crosslinks between two purine bases in 5'-GG-3', 5'-AG-3', and 5'-GNG-3' and that transplatin primarily forms mono adducts in the guanine bases and needs multiple guanine adducts to form crosslinks. …
- NAID 110006391303
Related Links
- intrastrand (not comparable) Within a strand. Retrieved from "https://en.wiktionary.org/w/index.php?title=intrastrand&oldid=27578233" Categories: English words prefixed with intra-English lemmas English adjectives Personal tools ...
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