English Journal

Rapid Restoration of Vascularity and Oxygenation in Mouse and Human Islets Transplanted to Omentum May Contribute to Their Superior Function Compared to Intraportally Transplanted Islets.

Espes D1,2, Lau J1,2, Quach M1, Ullsten S1, Christoffersson G1,3, Carlsson PO1,2.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.Am J Transplant.2016 Jun 20. doi: 10.1111/ajt.13927. [Epub ahead of print]
Transplantation of islets into the liver confers several site-specific challenges including a delayed vascularization and prevailing hypoxia. The greater omentum has in several experimental studies been suggested as an alternative implantation site for clinical use, but there has been no direct func
PMID 27321369

Positron Emission Tomography to assess the outcome of intraportal islet transplantation.

Eriksson O1, Selvaraju R2, Eich T3, Willny M2, Brismar TB4, Carlbom L5, Ahlström H5, Tufvesson G5, Lundgren T6, Korsgren O3.
Diabetes.Diabetes.2016 Jun 20. pii: db160222. [Epub ahead of print]
There currently exists no imaging methodology to monitor viable islet mass following clinical intraportal islet transplantation. We investigated the potential of the endocrine positron emission tomography (PET) marker [11C]5-hydroxy-tryptophan ([11C]5-HTP) for this purpose. In a preclinical proof of
PMID 27325286

Hepatic, gastric and intestinal first-pass effects of vitexin-2-O-rhamnoside in rats by ultra-high-performance liquid chromatography.

Gao Y1, Du Y2, Ying Z3, Leng A2, Zhang W1, Meng Y1, Li C1, Xu L1, Ying X1, Kang T1.
Biomedical chromatography : BMC.Biomed Chromatogr.2016 Feb;30(2):111-6. doi: 10.1002/bmc.3522. Epub 2015 Jun 26.
Previous research in our laboratory found that the absolute bioavailability of vitexin-2-O-rhamnoside (VR) was quite low at 4.89%. A rapid and sensitive UHPLC method using hesperidin as an internal standard was therefore developed and validated to investigate the reasons for this by determining VR
PMID 26031900