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within the molecule; occurring by a reaction between different parts of the same molecule

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ATP-Adenosine-Glutathione Cross-Linked Hemoglobin as Clinically Useful Oxygen Carrier.

Simoni J, Simoni G, Wesson DE, Feola M.SourceResearch Professor Texas Tech University Health Sciences Center 3601 4th Street Lubbock, TX 79430, USA. jan.simoni@ttuhsc.edu.
Current drug discovery technologies.Curr Drug Discov Technol.2012 Sep 1;9(3):173-87.
To attenuate hemoglobin's (Hb) intrinsic toxicity, Texas Tech University scientists developed a novel concept of "pharmacologic cross-linking" to formulate an effective oxygen carrier, HemoTech, which consists of purified bovine Hb cross-linked intramolecularly with ATP and intermolecularly with ade
PMID 21902624

Canto I, Soh UJ, Trejo J.SourceDepartment of Pharmacology, University of California, San Diego, Biomedical Sciences Building, Room 3044A, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA. joanntrejo@ucsd.edu.
Mini reviews in medicinal chemistry.Mini Rev Med Chem.2012 Aug 1;12(9):804-11.
The protease-activated receptors (PARs) are G protein-coupled receptors (GPCRs) that are uniquely activated by proteolysis. PARs mediate hemostasis, thrombosis, inflammation, embryonic development and progression of certain malignant cancers. The family of PARs include four members: PAR1, PAR2, PAR3
PMID 22681248