イントラクライン、細胞内分泌
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/07 17:31:41」(JST)
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Intracrine refers to a hormone that acts inside a cell, regulating intracellular events. Steroid hormones act through intracellular (mostly nuclear) receptors and, thus, may be considered to be intracrines. In contrast, peptide or protein hormones, in general, act as endocrines, autocrines, or paracrines by binding to their receptors present on the cell surface. Several peptide/protein hormones or their isoforms also act inside the cell through different mechanisms. These peptide/protein hormones, which have intracellular functions, are also called intracrines. The term 'intracrine' is thought to have been coined to represent peptide/protein hormones that also have intracellular actions.
The biological effects produced by intracellular actions are referred as intracrine effects, whereas those produced by binding to cell surface receptors are called endocrine, autocrine, or paracrine effects, depending on the origin of the hormone. The intracrine effect of some of the peptide/protein hormones are similar to their endocrine, autocrine, or paracrine effects; however, these effects are different for some other hormones.
Intracrine can also refer to a hormone acting within the cell that synthesizes it.[1]
See also
References
- ^ "intracrine - definition of intracrine in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia". Medical-dictionary.thefreedictionary.com. Retrieved 2011-11-08.
- Re, RN (Apr 2003). "The intracrine hypothesis and intracellular peptide hormone action". BioEssays 25 (4): 401–9. doi:10.1002/bies.10248. PMID 12655647.
- Re, RN (Jan 2002). "The origins of intracrine hormone action". Am J Med Sci. 323 (1): 43–8. doi:10.1097/00000441-200201000-00008. PMID 11814142.
- Kumar R, Singh VP, Baker KM. "The intracellular renin-angiotensin system: a new paradigm. Trends Endocrinol Metab. 2007 May 15. doi:10.1016/j.tem.2007.05.001 PMID 17509892.
- Fiaschi-Taesch, NM; Stewart, AF (Feb 2003). "Minireview: parathyroid hormone-related protein as an intracrine factor--trafficking mechanisms and functional consequences". Endocrinology 144 (2): 407–11. doi:10.1210/en.2002-220818. PMID 12538599.
- Sorensen, V; Nilsen, T; Wiedlocha, A (May 2006). "Functional diversity of FGF-2 isoforms by intracellular sorting". BioEssays 28 (5): 504–14. doi:10.1002/bies.20405. PMID 16615083.
- Singh, VP; Baker, KM; Kumar, R (Apr 2008). "Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production". Am J Physiol Heart Circ Physiol 294 (4): 1675–84. doi:10.1152/ajpheart.91493.2007. PMID 18296558.
Cell physiology: Cell signaling / Signal transduction
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Signaling pathways |
- GPCR
- RTK
- Notch
- JAK-STAT
- Akt/PKB
- Fas apoptosis
- Hippo
- PI3K/AKT/mTOR pathway
- Integrin receptors
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Agents |
Receptor ligands |
- Hormones
- Neurotransmitters/Neuropeptides/Neurohormones
- Cytokines
- Growth factors
- Signaling molecules
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Receptors |
- Cell surface
- Intracellular
- Co-receptor
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2nd messenger |
- cAMP-dependent pathway
- Ca2+ signaling
- Lipid signaling
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Assistants: |
- Signal transducing adaptor protein
- Scaffold protein
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Transcription factors |
- General
- Transcription preinitiation complex
- TFIID
- TFIIH
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By distance |
- Juxtacrine
- Autocrine / Paracrine
- Endocrine
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Other concepts |
- Intracrine action
- Neurocrine signaling
- Synaptic transmission
- Chemical synapse
- Neuroendocrine signaling
- Exocrine signalling
- Mechanotransduction
- Phototransduction
- Ion channel gating
- Gap junction
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Index of signal transduction
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Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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English Journal
- Could Intracrine Biology Play a Role in the Pathogenesis of Transmissable Spongiform Encephalopathies, Alzheimer's Disease and Other Neurodegenerative Diseases?
- Re RN.SourceResearch Division, Ochsner Clinic Foundation, Ochsner Health System, New Orleans, Louisiana.
- The American journal of the medical sciences.Am J Med Sci.2013 Oct 31. [Epub ahead of print]
- : Transmissible spongiform encephalopathies have been shown to result from the misfolding of normal cellular prion proteins in neurons caused by a transmissible abnormal form of the protein. In recent years, similar transmission of abnormal proteins capable of inducing abnormal folding of their norm
- PMID 24185262
- Lymphocyte GH-axis hormones in immunity.
- Weigent DA.SourceDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd., MCLM894, Birmingham, AL 35294-0005, United States. Electronic address: Weigent@uab.edu.
- Cellular immunology.Cell Immunol.2013 Oct 19;285(1-2):118-132. doi: 10.1016/j.cellimm.2013.10.003. [Epub ahead of print]
- The production and utilization of common ligands and their receptors by cells of the immune and neuroendocrine systems constitutes a biochemical information circuit between and within the immune and neuroendocrine systems. The sharing of ligands and receptors allows the immune system to serve as the
- PMID 24177252
- Vitamin D and DBP: The free hormone hypothesis revisited.
- Chun RF, Peercy BE, Orwoll ES, Nielson CM, Adams JS, Hewison M.SourceOrthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA.
- The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2013 Oct 4. pii: S0960-0760(13)00186-6. doi: 10.1016/j.jsbmb.2013.09.012. [Epub ahead of print]
- The last five years have witnessed a remarkable renaissance in vitamin D research and a complete re-evaluation of its benefits to human health. Two key factors have catalyzed these changes. First, it now seems likely that localized, tissue-specific, conversion of 25-hydroxyvitamin D (25OHD) to 1,25-
- PMID 24095930
Japanese Journal
- Healthy human salivary glands contain a DHEA-sulphate processing intracrine machinery, which is deranged in primary Sjogren's syndrome
- Spaan Michelle,Porola Pauliina,Laine Mikael,Rozman Blaz,Azuma Masayuki,Konttinen Yrjo T.
- JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13(7), 1261-1270, 2009
- NAID 120004710273
- The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription
- <最近のトピックス>ペプチドホルモンの細胞内作用 : イントラクリン仮説
Related Links
- Intracrine refers to a hormone that acts inside a cell. Steroid hormones act through intracellular (mostly nuclear) receptors and, thus, may be considered to be intracrines. In contrast, peptide or protein hormones, in general, act as endocrines, ...
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