WordNet

the act of spotting or staining something (同)spotting, maculation
(histology) the use of a dye to color specimens for microscopic study
any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system
located or occurring within a cell or cells; "intracellular fluid"

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1. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
2. 免疫系におけるサイトカインの役割 role of cytokines in the immune system
3. 心不全における一酸化窒素、その他のホルモン、サイトカイン、およびケモカイン nitric oxide other hormones cytokines and chemokines in heart failure
4. リウマチ性疾患におけるサイトカインの役割 role of cytokines in rheumatic diseases
5. 肥満細胞：増殖・分化、識別、および生理学的役割 mast cells development identification and physiologic roles

English Journal

Poor HIV control in HLA-B*27 and B*57/58 noncontrollers is associated with limited number of polyfunctional Gag p24-specific CD8+ T cells.

Techakriengkrai N, Tansiri Y, Hansasuta P.SourceaDivision of Virology, Department of Microbiology, Faculty of Medicine bInterdisciplinary Program of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand.
AIDS (London, England).AIDS.2013 Jan 2;27(1):17-27. doi: 10.1097/QAD.0b013e32835ac0e1.
OBJECTIVES: : Analysis of immune response in HIV controllers, a unique group of infected individuals who are able to control HIV naturally, has provided us a chance to investigate the roles of host immune responses in HIV control.DESIGN: : In this study, the functional quality of HIV Gag p24-specifi
PMID 23079801

Enriched CD161high CCR6+ γδ T Cells in the Cerebrospinal Fluid of Patients With Multiple Sclerosis.

Schirmer L, Rothhammer V, Hemmer B, Korn T.AbstractOBJECTIVE To investigate the expression of CD161 (KLRB1) and CCR6 on human γδ T cells in blood and cerebrospinal fluid (CSF) of patients with a clinically isolated syndrome (CIS) and multiple sclerosis (MS) in relapse. DESIGN Flow cytometry analysis of CD161 and CCR6 expression and intracellular cytokine staining for interleukin 17 and interferon-γ on human γδ T cells in blood and CSF samples. SETTING Department of Neurology, Klinikum rechts der Isar, Technische Universität München, a tertiary referral center. PATIENTS Twenty-six patients with CIS/MS in active relapse, 10 patients with other autoimmune disorders, 12 patients with neuroinfectious diseases, and 15 patients with noninflammatory neurological diseases. MAIN OUTCOME MEASURES Frequencies of CD161high and CCR6+ γδ T cells in blood and CSF samples of patients with CIS/MS in relapse and control patients. RESULTS γδ T cells were increased in both blood and CSF of patients with CIS/MS in relapse as compared with controls with noninflammatory disease. The fraction of CD161high CCR6+ γδ T cells was significantly higher in the CSF of patients with CIS/MS in relapse than of those with systemic autoimmune disorders or controls with noninflammatory disease. The CD161high CCR6+ double-positive γδ T-cell population was further enriched in the CSF in relation to blood in patients with CIS/MS in relapse but not in patients with infectious disease or the other control groups. The CD161high CCR6+ γδ T-cell population was characterized by its capacity to produce interleukin 17. CONCLUSION Interleukin 17-producing CD161high CCR6+ γδ T cells might contribute to the compartmentalized inflammatory process in the central nervous system of patients with MS.
Archives of neurology.Arch Neurol.2012 Dec 17:1-7. doi: 10.1001/2013.jamaneurol.409. [Epub ahead of print]
OBJECTIVE To investigate the expression of CD161 (KLRB1) and CCR6 on human γδ T cells in blood and cerebrospinal fluid (CSF) of patients with a clinically isolated syndrome (CIS) and multiple sclerosis (MS) in relapse. DESIGN Flow cytometry analysis of CD161 and CCR6 expression and intracellular c
PMID 23247910

Japanese Journal

NKG2D+CD4+ T Cells with Immune Suppressive Property Increase in Patients with Colorectal Cancer

Yamamoto Manabu,Saito Hiroaki,Kihara Kyoichi,Katano Kuniyuki,Ikeguchi Masahide
Yonago Acta medica 53(1), 9-16, 2010-3
… Furthermore, intracellular cytokine staining was carried out to determine the cytokine profile of NKG2D+CD4+ T cells in colorectal cancer patients. …
NAID 120002003945

ヒト関節リウマチにおけるTh17

山田久方
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 32(4), 249-255, 2009-08-31
関節炎など自己免疫疾患動物モデルの多くは，Th1免疫反応により発症すると長年考えられてきたが，近年IL-17と，それを産生する新しいヘルパーCD4T細胞サブセットのTh17細胞がこれらの発症に重要なことが明らかとなってきた．ヒト関節リウマチ（RA）も同様にTh17細胞が重要な役割を担うと考えられるようになり，RA関節でのIL-17検出も報告されている．またIL-17の示す種 …
NAID 10026352183