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English Journal

Intra-carotid angiotensin II activates tyrosine hydroxylase expressing rostral ventrolateral medulla neurons following blood-brain barrier disruption in rats.

Yao ST, May CN.SourceThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, 3010, Australia. Electronic address: song.yao@florey.edu.au.
Neuroscience.Neuroscience.2013 Apr 19. pii: S0306-4522(13)00341-2. doi: 10.1016/j.neuroscience.2013.04.023. [Epub ahead of print]
Angiotensin II (Ang II) in the periphery and within the brain plays important roles in blood pressure control. Circulating angiotensin is normally excluded from the brain by the blood-brain-barrier (BBB), but there is evidence that in some diseases there is disruption of the BBB that could allow cir
PMID 23608099

Intravenous mannitol does not increase blood-brain barrier permeability to inert dyes in the adult rat forebrain.

Chen KB, Wei VC, Yen LF, Poon KS, Liu YC, Cheng KS, Chang CS, Lai TW.SourceGraduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.
Neuroreport.Neuroreport.2013 Apr 17;24(6):303-7. doi: 10.1097/WNR.0b013e32835f8acb.
Intravenous mannitol (IV-M) is widely administered in the clinic to lower intracranial pressure in patients with brain trauma and stroke. However, intracarotid arterial mannitol (ICA-M) is known to potently open the blood-brain barrier (BBB) to serum protein tracers such as the Evans blue dye (EBD).
PMID 23426109

Development of a preclinical therapeutic model of human brain metastasis with chemoradiotherapy.

Martínez-Aranda A, Hernández V, Picón C, Modolell I, Sierra A.SourceBiological Clues of the Invasive and Metastatic Phenotype Group, Bellvitge Biomedical Research Institute (IDIBELL), L' Hospitalet de Llobregat, Barcelona 08907, Spain. asierra@idibell.cat.
International journal of molecular sciences.Int J Mol Sci.2013 Apr 16;14(4):8306-27. doi: 10.3390/ijms14048306.
Currently, survival of breast cancer patients with brain metastasis ranges from 2 to 16 months. In experimental brain metastasis studies, only 10% of lesions with the highest permeability exhibited cytotoxic responses to paclitaxel or doxorubicin. Therefore, radiation is the most frequently used tre
PMID 23591844

Intravenous Methylprednisolone Reduces the Risk of Propofol-Induced Adverse Effects During Wada Testing

MIKUNI Nobuhiro,YOKOYAMA Youhei,MATSUMOTO Atsuhito,KIKUCHI Takayuki,YAMADA Shigeki,HASHIMOTO Nobuo,MIYAMOTO Susumu
Neurologia medico-chirurgica = 神経外科 50(8), 622-626, 2010-08-15
… The adverse effects and risks associated with intracarotid propofol injection during Wada testing were retrospectively compared in two groups of patients with (n = 75) and without (n = 58) intravenous methylprednisolone administered before intracarotid propofol injection. …
NAID 10026651242

Intracarotid injection of granulocyte-macrophage colony-stimulating factor induces neuroprotection in a rat transient middle cerebral artery occlusion model