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English Journal

Boron containing magnetic nanoparticles for neutron capture therapy - an innovative approach for specifically targeting tumors.

Tietze R1, Unterweger H1, Dürr S1, Lyer S1, Canella L2, Kudejova P2, Wagner FM2, Petry W2, Taccardi N3, Alexiou C4.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.Appl Radiat Isot.2015 Dec;106:151-5. doi: 10.1016/j.apradiso.2015.07.028. Epub 2015 Jul 26.
The selective delivery of (10)B into the tumor tissue remains to be further improved for successful and reliable Boron Neutron Capture Therapy applications. Magnetic Drug Targeting using intraarterially administered superparamagnetic nanoparticles and external magnetic fields already exhibited convi
PMID 26242559

Intraarterial Microdosing: A Novel Drug Development Approach, Proof-of-Concept PET Study in Rats.

Burt T1, Rouse DC2, Lee K3, Wu H2, Layton AT2, Hawk TC2, Weitzel DH2, Chin BB2, Cohen-Wolkowiez M2, Chow SC2, Noveck RJ2.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.J Nucl Med.2015 Nov;56(11):1793-9. doi: 10.2967/jnumed.115.160986. Epub 2015 Aug 27.
Intraarterial microdosing (IAM) is a novel drug development approach combining intraarterial drug delivery and microdosing. We aimed to demonstrate that IAM leads to target exposure similar to that of systemic full-dose administration but with minimal systemic exposure. IAM could enable the safe, in
PMID 26315828

ICAM1 depletion reduces spinal metastasis formation in vivo and improves neurological outcome.

Broggini T1, Czabanka M2, Piffko A1, Harms C3, Hoffmann C3, Mrowka R4, Wenke F4, Deutsch U5, Grötzinger C6, Vajkoczy P1.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society.Eur Spine J.2015 Oct;24(10):2173-81. doi: 10.1007/s00586-015-3811-7. Epub 2015 Feb 25.
INTRODUCTION: Clinical treatment of spinal metastasis is gaining in complexity while the underlying biology remains unknown. Insufficient biological understanding is due to a lack of suitable experimental animal models. Intercellular adhesion molecule-1 (ICAM1) has been implicated in metastasis form
PMID 25711910

小山淳一,花岡吉亀,佐藤篤
脳神経血管内治療 7(3), 215-220, 2013
【目的】Angio-Seal使用時にコラーゲンスポンジが血管内留置され止血不全となったが，「route regaining technique」により応急的に止血することができた1例を報告する．【症例】66歳，女性．脳動脈瘤に対しコイル塞栓術施行後，Angio-Sealによる止血を試みた．コラーゲンスポンジが血管内で展開され止血不全となった．本技法により，同じ血管穿刺部を経由して再度血管内腔に到達 …
NAID 130003388049

松丸克彦,石井耕司,和久井紀貴 [他],篠原正夫,永井英成,大塚由一郎,渡邊正志,野中博子,住野泰清,三木一正
肝臓 47(8), 398-404, 2006
症例56歳男性．大腸癌の手術1カ月後から肝転移に対して5-FU（1500mg/body/週，総投与量76.5g，投与期間18カ月）を用いて動注化学療法を施行した．病巣は縮小傾向にあり有効と判断して治療を継続していたが，18カ月の治療期間中に血清トランスアミナーゼ値の変動は全くなかったにもかかわらず，治療開始6カ月後より，血小板減少，肝予備能の著明な低下，18カ月後には腹水が貯留した．抗癌剤投与を中 …
NAID 40007384613

高里良男,正岡博幸,早川隆宣,秋元秀昭,倉本憲明
脳卒中 22(3), 435-439, 2000
予後不良が高頻度とされる急性脳主幹動脈閉塞の予後向上を目指して局所動注血栓溶解(A群21例)を行い,さらに脳低体温を追加(B群21例)した.両群を比較分析した.A群は平均67.6歳の意識障害(平均GCS 8.6)と局所神経脱落症状を呈した初期21例の患者で,マイクロカテーテルで血栓を破砕しながらpro-urokinase (pro-UK)の局所動注を行った.B群は上記治療後に脳低体温(35℃×3日 …
NAID 130003439081