- 関
- IL-5 receptor、IL5 receptor
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/08 12:16:55」(JST)
[Wiki en表示]
| interleukin 5 receptor, alpha |
| Identifiers |
| Symbol |
IL5RA |
| Alt. symbols |
IL5R |
| Entrez |
3568 |
| HUGO |
6017 |
| OMIM |
147851 |
| RefSeq |
NM_175725 |
| UniProt |
Q01344 |
| Other data |
| Locus |
Chr. 3 p26-p24 |
| colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
| Identifiers |
| Symbol |
CSF2RB |
| Alt. symbols |
IL3RB |
| Entrez |
1439 |
| HUGO |
2436 |
| OMIM |
138981 |
| RefSeq |
NM_000395 |
| UniProt |
P32927 |
| Other data |
| Locus |
Chr. 22 q12.2-13.1 |
The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB.[1][2]
The IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer composed of two polypeptide chains, one α subunit, which binds IL-5 and confers upon the receptor cytokine specificity, and one β subunit, which contains the signal transduction domains.
Contents
- 1 α-subunit
- 2 β-subunit
- 3 References
- 4 External links
α-subunit[edit]
The IL-5Rα chain is exclusively expressed by eosinophils, some basophils and murine B1 cells or B cell precursors.[3] Like many other cytokine receptors, alternative splicing of the α-chain gene results in expression of either a membrane bound or soluble form of the bα-chain. The soluble form does not lead to signal transduction and therefore has an antagonistic effect on IL-5 signaling. Both monomeric forms of IL-5Rα are low affinity receptors, while dimerization with the β-chain produces a high affinity receptor.[4] In either case, the α-chain exclusively binds IL-5 and the intra-cellular portion of IL-5Rα is associated with Janus kinase (JAK) 2, a protein tyrosine-kinase essential in IL-5 signal transduction.[5][6]
β-subunit[edit]
The β-subunit of the IL-5 receptor is responsible for signal transduction and contains several intracellular signaling domains. Unlike the α-chain, the β-chain does not bind IL-5, is not specific to this cytokine, and is expressed on practically all leukocytes. In fact, the β-subunit of the IL-5 receptor is also found in IL-3 and GM-CSF receptors where it is associated with IL-3Rα and GM-CSFRα subunits respectively.[7] Therefore, it is known as the common β receptor or βc. As with the IL-5Rα subunit, the β subunit’s cytoplasmic domain is constitutively associated with JAK2,[8] as well as LYN,[9] another tyrosine kinase, which are both essential for IL-5 signal transduction.[10]
References[edit]
- ^ Takatsu K, Tominaga A (1991). "Interleukin 5 and its receptor". Prog. Growth Factor Res. 3 (2): 87–102. doi:10.1016/S0955-2235(05)80001-8. PMID 1773042.
- ^ Murata Y, Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K (1992). "Molecular cloning and expression of the human interleukin 5 receptor". J. Exp. Med. 175 (2): 341–51. doi:10.1084/jem.175.2.341. PMC 2119102. PMID 1732409.
- ^ Geijsen N, Koenderman L, Coffer PJ (March 2001). "Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family". Cytokine Growth Factor Rev. 12 (1): 19–25. doi:10.1016/S1359-6101(00)00019-8. PMID 11312115.
- ^ Tavernier J, Devos R, Cornelis S, Tuypens T, Van der Heyden J, Fiers W, Plaetinck G (September 1991). "A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF". Cell 66 (6): 1175–84. doi:10.1016/0092-8674(91)90040-6. PMID 1833065.
- ^ Ogata N, Kouro T, Yamada A, Koike M, Hanai N, Ishikawa T, Takatsu K (April 1998). "JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation". Blood 91 (7): 2264–71. PMID 9516124.
- ^ Takaki S, Kanazawa H, Shiiba M, Takatsu K (November 1994). "A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction". Mol. Cell. Biol. 14 (11): 7404–13. PMC 359275. PMID 7935454.
- ^ Martinez-Moczygemba M, Huston DP (October 2003). "Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF". J. Allergy Clin. Immunol. 112 (4): 653–65; quiz 666. doi:10.1016/j.jaci.2003.08.015. PMID 14564341.
- ^ Quelle FW, Sato N, Witthuhn BA, Inhorn RC, Eder M, Miyajima A, Griffin JD, Ihle JN (July 1994). "JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region". Mol. Cell. Biol. 14 (7): 4335–41. PMC 358804. PMID 8007942.
- ^ Li Y, Shen BF, Karanes C, Sensenbrenner L, Chen B (August 1995). "Association between Lyn protein tyrosine kinase (p53/56lyn) and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e)". J. Immunol. 155 (4): 2165–74. PMID 7636265.
- ^ Sato N, Sakamaki K, Terada N, Arai K, Miyajima A (November 1993). "Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling". EMBO J. 12 (11): 4181–9. PMC 413712. PMID 8223433.
External links[edit]
- Receptors, Interleukin-5 at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Cytokine receptors
|
|
Chemokine receptor
(GPCRs) |
| CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
|
|
| CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
|
|
| Other |
|
|
|
| TNF receptor |
| 1-10 |
- TNFRSF1 (CD120)
- TNFRSF1A (CD120a)
- TNFRSF1B (CD120b)
- TNFRSF3 (Lymphotoxin beta receptor)
- TNFRSF4 (CD134)
- TNFRSF5 (CD40)
- TNFRSF6 (FAS)
- TNFRSF6B
- TNFRSF7 (CD27)
- TNFRSF8 (CD30)
- TNFRSF9 (CD137)
|
|
| 11-20 |
- TNFRSF10A (CD261)
- TNFRSF10B (CD262)
- TNFRSF10C (CD263)
- TNFRSF10D (CD264)
- TNFRSF11A (CD265/RANK)
- TNFRSF11B (Osteoprotegerin)
- TNFRSF12A (CD266)
- TNFRSF13B (CD267)
- TNFRSF13C
- TNFRSF14 (CD268)
- TNFRSF16 (Nerve growth factor receptor)
- TNFRSF17 (CD269)
- TNFRSF18
- TNFRSF19
|
|
| 21-25 |
- TNFRSF21
- TNFRSF25
- TNFRSF27
|
|
|
| JAK-STAT |
| Type I |
| γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
|
|
| β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
|
|
| gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
|
|
| IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
|
|
| Other |
- hormone receptor: GH
- prolactin
|
|
|
| Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
|
|
|
| Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
|
|
| IL 17 family |
- IL-17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
|
|
| S/T |
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
UpToDate Contents
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English Journal
- A Sensitive and Versatile Cytokine Bioassay Based on Type I Interferon Signaling in 2fTGH Cells.
- Zabeau L, Van der Heyden J, Tavernier J.SourceDepartment of Medical Protein Research, Flanders Institute for Biotechnology, Ghent University, Faculty of Medicine and Health Sciences, Ghent, BE, 9000, Belgium.
- Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2012;820:231-7.
- We have designed a sensitive and versatile bioassay for quantification of series of cytokines. The assay makes use of chimeric receptors composed of the extracellular, ligand-binding part of the cognate cytokine receptor and the transmembrane and cytosolic part of the type I interferon receptor. Rec
- PMID 22131035
- Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Rα.
- Patino E, Kotzsch A, Saremba S, Nickel J, Schmitz W, Sebald W, Mueller TD.SourceLehrstuhl für Molekulare Pflanzenphysiologie und Biophysik, Julius-von-Sachs Institut der Universität Würzburg, Julius-von-Sachs Platz 2, D-97082 Würzburg, Germany.
- Structure (London, England : 1993).Structure.2011 Dec 7;19(12):1864-75.
- Interleukin-5 (IL-5) is the key mediator for the function of eosinophil granulocytes, whose deregulation is characteristic of hypereosinophilic diseases and presumably contributes to allergic asthma. IL-5 signaling involves two transmembrane receptors, IL-5Rα and the common β chain, which upon for
- PMID 22153509
Japanese Journal
- Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement
- Interleukin-5 and IL-5 receptor in health and diseases
- 腹水と蛋白漏出性胃腸症をともなった好酸球性胃腸炎の1例
- 日本消化器病學會雜誌 = The Japanese journal of gastro-enterology 106(11), 1625-1635, 2009-11-05
- NAID 10026134201
Related Links
- The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB. [edit] References. ^ Takatsu K, Tominaga A (1991). "Interleukin 5 and its receptor". Prog. Growth Factor Res. ...
Related Pictures
★リンクテーブル★
[★]
- 関
- IL5 receptor、interleukin-5 receptor
[★]
- 英
- interleukin-5 receptor、IL-5 receptor
- 関
- IL-5受容体、インターロイキン5レセプター、IL-5レセプター
[★]
- 英
- interleukin-5 receptor、IL-5 receptor
- 関
- IL-5受容体、インターロイキン5受容体、IL-5レセプター
[★]
[★]
インターロイキン IL
[★]
インターロイキン IL