関: anakinra

WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
a drug that neutralizes or counteracts the effects of another drug
a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

PrepTutorEJDIC

蛋白(たんばく)質
対立する人,敵対者,競争相手(opponent)
=sense organ / 受信装置

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1. クリオピリン関連周期性発熱症候群および関連疾患 cryopyrin associated periodic syndromes and related disorders
2. 周期性発熱症候群およびその他の自己炎症性疾患：概要 periodic fever syndromes and other autoinflammatory diseases an overview
3. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
4. リウマチ性疾患における生物学的製剤の概要 overview of biologic agents in the rheumatic diseases
5. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases

English Journal

Short- and long-term effects of platelet-rich plasma upon healthy equine joints: Clinical and laboratory aspects.

Moraes AP1, Moreira JJ1, Brossi PM1, Machado TS1, Michelacci YM1, Baccarin RY1.
The Canadian veterinary journal. La revue vétérinaire canadienne.Can Vet J.2015 Aug;56(8):831-8.
in

English, FrenchEffets à court et à long terme de le plasma riche en plaquettes sur les articulations sains chez les équines : aspects cliniques et laboratoiren. Cette étude a pour but de vérifier si les réactions inflammatoires passagères induites par l’administration intra articulai

PMID 26246629

Serum concentrations of canine interleukin-1 receptor antagonist protein in healthy dogs after incubation using an autologous serum processing system.

Huggins SS1, Suchodolski JS2, Bearden RN1, Steiner JM2, Saunders WB3.
Research in veterinary science.Res Vet Sci.2015 Aug;101:28-33. doi: 10.1016/j.rvsc.2015.05.012. Epub 2015 May 27.
The objectives of this study were to optimize and validate a canine IL-1RA ELISA using commercially available reagents and to determine the effect of an autologous serum processing system (IRAP II) on IL-1RA concentrations in canine serum. The clinical detection limit of the optimized ELISA was 188.
PMID 26267085

Target Inhibition of IL-1 Receptor Prevents Ifosfamide Induced Hemorrhagic Cystitis in Mice.

Leite CA1, Alencar VT2, Melo DL2, Mota JM3, Melo PH4, Mourão LT2, Wong DV2, Magalhães PJ2, Santos AA2, Brito GA5, Lima-Júnior RC2, Cunha FQ6, Ribeiro RA7.
The Journal of urology.J Urol.2015 Jul 26. pii: S0022-5347(15)04490-0. doi: 10.1016/j.juro.2015.07.088. [Epub ahead of print]
PURPOSE: Hemorrhagic cystitis is an important dose limiting side effect of ifosfamide based cancer chemotherapy. Despite chemoprophylaxis inflammation can still be found in cystoscopy guided biopsies. Previous studies confirmed the role of TNF-α and IL-1β. We evaluated the protective effect of the
PMID 26220217

Japanese Journal

Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice

Fujii Hiroshi,Baba Tomohisa,Ishida Yuko,Kondo Toshikazu,Yamagishi Masakazu,Kawano Mitsuhiro,Mukaida Naofumi
Arthritis and Rheumatism 63(1), 96-106, 2011-01-00
… Given the role of intraarticular macrophage infiltration in RA, this study was undertaken to address the pathogenic role of CCR2, a chemokine receptor that is abundantly expressed by macrophages, in Il1rn-deficient mice, a mouse model of RA. … Methods Il1rn-deficient and Il1rn and Ccr2-double-deficient mice were subjected to clinical assessment of arthritis and histologic examination. …
NAID 120002754103

Inhibitory Effect of Vitamin K2 on Interleukin-1.BETA.-Stimulated Proliferation of Human Osteoblasts

Matsuda Tomohiro,Kondo Ayami,Tsunashima Yoshihiko [他],Togari Akifumi
Biological and Pharmaceutical Bulletin 33(5), 804-808, 2010
… The effect of the proinflammatory cytokine interleukin (IL)-1β on the cellular proliferation of human osteoblastic cells (SaM-1) and osteosarcoma-derived cells (SaOS-2, HOS, and MG-63) was examined. … IL-1β stimulated the proliferation of SaM-1 and MG-63 cells, but had no effect on that of SaOS-2 or HOS cells. …
NAID 130000248040

Angiotensin 11 Enhances Interleukin-1.BETA.-Induced MMP-9 Secretion in Adult Rat Cardiac Fibroblasts

Okada Muneyoshi,Yamawaki Hideyuki,Hara Yukio
日本獣醫學会会誌 72(6), 735-739, 2010
… Inflammatory cytokine, interleukin (IL)-1β induces MMP-9 secretion in cultured cardiac fibroblasts. … In the present study, we investigated the effect of angiotensin II on basal and IL-1β-induced MMP-9 secretion in adult rat cardiac fibroblasts. …
NAID 130000168026