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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/05/20 05:16:29」(JST)

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Interleukin 19 (IL19) is a protein that in humans is encoded by the IL19 gene.^[5]

Function

The protein encoded by this gene is a cytokine that belongs to the IL-10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the interleukin-20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.^[5]

Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 gene is expressed in resting monocytes and B cells. It is up-regulated in monocytes following stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF), lipopolysaccharide, or Pam3CSK4.^[6] and ^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142224 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016524 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ ^a ^b "Entrez Gene: Interleukin 19".
^ Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A (Jan 2003). "Crystal structure of interleukin-19 defines a new subfamily of helical cytokines". The Journal of Biological Chemistry. 278 (5): 3308–13. doi:10.1074/jbc.M208602200. PMID 12403790.
^ Kragstrup TW, Andersen T, Holm C, Schiøttz-Christensen B, Jurik AG, Hvid M, Deleuran B (May 2015). "Toll-like receptor 2 and 4 induced interleukin-19 dampens immune reactions and associates inversely with spondyloarthritis disease activity". Clinical and Experimental Immunology. 180 (2): 233–42. doi:10.1111/cei.12577. PMC 4408158. PMID 25639337.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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…induction of Th17 pathway genes amongst the ichthyosis subgroups tested, with striking upregulation of IL-19, which leads to amplification of IL-17 effects on keratinocytes. NS is characterized by the classic…

English Journal

Assessment and Clinical Relevance of Serum IL-19 Levels in Psoriasis and Atopic Dermatitis Using a Sensitive and Specific Novel Immunoassay.

Konrad RJ, Higgs RE, Rodgers GH, Ming W, Qian YW, Bivi N, Mack JK, Siegel RW, Nickoloff BJ.
Scientific reports. 2019 Mar;9(1)5211.
Because development of reliable biomarkers in psoriasis and atopic dermatitis has lagged behind therapeutic progress, we created a blood-based test to fill the void in objective methods available for dermatological assessments. Our novel interleukin-19 (IL-19) immunoassay was initially tested to det
PMID 30914699

Exogenous IL-19 attenuates acute ischaemic injury and improves survival in male mice with myocardial infarction.

An W, Yu Y, Zhang Y, Zhang Z, Yu Y, Zhao X.
British journal of pharmacology. 2019 Mar;176(5)699-710.
Myocardial infarction (MI) is one of the leading causes of death in China and often results in the development of heart failure. In this work, we tested the therapeutic role of Interleukin-19 (IL-19) in mice with MI and investigated the underlying molecular mechanism. Mice were subjected to MI by li
PMID 30460984

Expression of interleukin (IL)-10 family cytokines in aqueous humour of patients with specific endogenous uveitic entities: elevated levels of IL-19 in human leucocyte antigen-B27-associated uveitis.

Abu El-Asrar AM, Berghmans N, Al-Obeidan SA, Gikandi PW, Opdenakker G, Van Damme J, Struyf S.
Acta ophthalmologica. 2019 Feb;().
Evidence exists that the interleukin (IL)-10 family of cytokines is involved in autoimmune diseases. The aim of this study was to analyse the levels of the IL-10 family cytokines IL-10, IL-19, IL-20, IL-22, IL-26, IL-28A and IL-29 in aqueous humour (AH) samples from patients with specific uveitic en
PMID 30761764

Japanese Journal

The Role of Interleukin-19 in Contact Hypersensitivity

Fujimoto Yasuyuki,Fujita Takashi,Kuramoto Nobuyuki,Kuwamura Mitsuru,Izawa Takeshi,Nishiyama Kazuhiro,Yoshida Natsuho,Nakajima Hidemitsu,Takeuchi Tadayoshi,Azuma Yasu-Taka
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 41(2), 182-189, 2018
… <p>Interleukin (IL)-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. … The gastrointestinal tissues of IL-19 knockout mice show exacerbated experimental colitis mediated by the innate immune system and T cells. … There is an increasing focus on the interaction and relationship of IL-19 with the function of T cells. … Therefore, we asked whether IL-19 causes CHS. …
NAID 130006329250

Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis

Fujimoto Yasuyuki,Azuma Yasu-Taka,Matsuo Yukiko,Kuwamura Mitsuru,Kuramoto Nobuyuki,Miki Mariko,Azuma Naoki,Teramoto Midori,Nishiyama Kazuhiro,Izawa Takeshi,Nakajima Hidemitsu,Takeuchi Tadayoshi,東泰孝
Naunyn-Schmiedeberg's Archives of Pharmacology 390(3), 261-268, 2017-03
NAID 120006399470

Methylmercury induces expression of interleukin-1β and interleukin-19 in mice brains

Takahashi Tsutomu,Iwai-Shimada Miyuki,Syakushi Yukina,Kim Min-Seok,Hwang Gi-Wook,Miura Nobuhiko,Naganuma Akira
Fundamental Toxicological Sciences 2(6), 239-243, 2015
… We examined the effect of methylmercury administration on expression of interleukin genes in brain of mice. … We found that gene expression of IL-1β and IL-19 was increased in the brain after the administration of methylmercury. …
NAID 130005114963

「インターロイキン19」

IL19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N1F
Identifiers
Aliases	IL19, IL-10C, MDA1, NG.1, ZMDA1, Interleukin 19, IL-19
External IDs	MGI: 1890472 HomoloGene: 17813 GeneCards: IL19
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,842,981 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	130,940,115 bp
Gene ontology
Molecular function	• cytokine activity; • protein binding;
Cellular component	• extracellular region; • extracellular space;
Biological process	• interleukin-6 biosynthetic process; • negative regulation of extrinsic apoptotic signaling pathway; • positive regulation of apoptotic signaling pathway; • positive regulation of intrinsic apoptotic signaling pathway; • signal transduction; • reactive oxygen species metabolic process; • apoptotic process; • immune response; • regulation of receptor activity; • cytokine-mediated signaling pathway; • negative regulation of low-density lipoprotein particle clearance;
	Sources:Amigo / QuickGO
Orthologs
	29949
	329244
	ENSG00000142224
	ENSMUSG00000016524
	Q9UHD0
	Q8CJ70
	NM_013371; NM_153758; NM_001369605
	NM_001009940; NM_001355135
	NP_037503; NP_715639; NP_001356534
	NP_001009940; NP_001342064
	Wikidata
View/Edit Human	View/Edit Mouse