インターロイキン16
- 関
- IL-16、IL16
WordNet
- any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/02 20:36:06」(JST)
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Interleukin 16 |
PDB rendering based on 1i16. |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1I16, 1X6D
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Identifiers |
Symbols |
IL16; LCF; NIL16; PRIL16; prIL-16 |
External IDs |
OMIM: 603035 MGI: 1270855 HomoloGene: 18157 GeneCards: IL16 Gene |
Gene Ontology |
Molecular function |
• cytokine activity
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Cellular component |
• extracellular space
• nucleus
• cytoplasm
• plasma membrane
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Biological process |
• transcription, DNA-dependent
• regulation of transcription, DNA-dependent
• immune response
• virus-host interaction
• leukocyte chemotaxis
• induction of positive chemotaxis
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
3603 |
16170 |
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Ensembl |
ENSG00000172349 |
ENSMUSG00000001741 |
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UniProt |
Q14005 |
O54824 |
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RefSeq (mRNA) |
NM_001172128.1 |
NM_010551.3 |
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RefSeq (protein) |
NP_001165599.1 |
NP_034681.2 |
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Location (UCSC) |
Chr 15:
81.45 – 81.61 Mb |
Chr 7:
83.64 – 83.75 Mb |
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PubMed search |
[1] |
[2] |
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Pro-interleukin-16 is a protein that in humans is encoded by the IL16 gene.[1][2] This gene was discovered in 1982 at Boston University by Dr. David Center and Dr. William Cruikshank.[3]
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]
Interleukin 16 (IL-16) is a cytokine that released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4.
IL-16 was originally described as a factor that could attract activated T cells in humans, it was previously called lymphocyte chemoattractant factor (LCF).[3] Since then, this interleukin has been shown to recruit and activate many other cells expressing the CD4 molecule, including monocytes, eosinophils, and dendritic cells.[4]
The structure of IL-16 was determined following its cloning in 1994.[5] This cytokine is produced as a precursor peptide (pro-IL-16) that requires processing by an enzyme called caspase-3 to become active. CD4 is the cell signaling receptor for mature IL-16.
Interactions
Interleukin 16 has been shown to interact with Kir2.1,[6] KCNJ10,[6] GRIN2D,[6] GRIN2A,[6] PPP1R12B,[7] PPP1R12A[7] and KCNJ15.[6]
References
- ^ Baier M, Bannert N, Werner A, Lang K, Kurth R (Jun 1997). "Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor". Proc Natl Acad Sci U S A 94 (10): 5273–7. doi:10.1073/pnas.94.10.5273. PMC 24668. PMID 9144227. //www.ncbi.nlm.nih.gov/pmc/articles/PMC24668/.
- ^ a b "Entrez Gene: IL16 interleukin 16 (lymphocyte chemoattractant factor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3603.
- ^ a b Cruikshank W, Center DM (1982). "Modulation of lymphocyte migration by human lymphokines. II. Purification of a lymphotactic factor (LCF)". J. Immunol. 128 (6): 2569–74. PMID 7042841. http://www.jimmunol.org/cgi/reprint/128/6/2569.
- ^ Cruikshank WW, Kornfeld H, Center DM (2000). "Interleukin-16". J. Leukoc. Biol. 67 (6): 757–66. PMID 10857846. http://www.jleukbio.org/cgi/content/abstract/67/6/757.
- ^ Cruikshank WW, Center DM, Nisar N, Wu M, Natke B, Theodore AC, Kornfeld H (1994). "Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5109–13. doi:10.1073/pnas.91.11.5109. PMC 43941. PMID 7910967. //www.ncbi.nlm.nih.gov/pmc/articles/PMC43941/.
- ^ a b c d e Kurschner, C; Yuzaki M (Sep. 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". J. Neurosci. (UNITED STATES) 19 (18): 7770–80. PMID 10479680.
- ^ a b Bannert, Norbert; Vollhardt Karin, Asomuddinov Bakhtier, Haag Marion, König Herbert, Norley Stephen, Kurth Reinhard (Oct. 2003). "PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits". J. Biol. Chem. (United States) 278 (43): 42190–9. doi:10.1074/jbc.M306669200. ISSN 0021-9258. PMID 12923170.
Further reading
- Wilson KC, Center DM, Cruikshank WW (2005). "The effect of interleukin-16 and its precursor on T lymphocyte activation and growth". Growth Factors 22 (2): 97–104. doi:10.1080/08977190410001704679. PMID 15253385.
- Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini reviews in medicinal chemistry 5 (12): 1093–101. doi:10.2174/138955705774933383. PMID 16375755.
- Rand TH, Cruikshank WW, Center DM, Weller PF (1991). "CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration". J. Exp. Med. 173 (6): 1521–8. doi:10.1084/jem.173.6.1521. PMC 2190841. PMID 1851800. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2190841/.
- Ryan TC, Cruikshank WW, Kornfeld H, et al. (1995). "The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration". J. Biol. Chem. 270 (29): 17081–6. doi:10.1074/jbc.270.29.17081. PMID 7615501.
- Cruikshank WW, Center DM, Nisar N, et al. (1994). "Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5109–13. doi:10.1073/pnas.91.11.5109. PMC 43941. PMID 7910967. //www.ncbi.nlm.nih.gov/pmc/articles/PMC43941/.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Parada NA, Cruikshank WW, Danis HL, et al. (1996). "IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C". Cell. Immunol. 168 (1): 100–6. doi:10.1006/cimm.1996.0054. PMID 8599832.
- Bannert N, Baier M, Werner A, Kurth R (1996). "Interleukin-16 or not?". Nature 381 (6577): 30. doi:10.1038/381030a0. PMID 8609984.
- Maciaszek JW, Parada NA, Cruikshank WW, et al. (1997). "IL-16 represses HIV-1 promoter activity". J. Immunol. 158 (1): 5–8. PMID 8977168.
- Laberge S, Ernst P, Ghaffar O, et al. (1997). "Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma". Am. J. Respir. Cell Mol. Biol. 17 (2): 193–202. PMID 9271307.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Zhang Y, Center DM, Wu DM, et al. (1998). "Processing and activation of pro-interleukin-16 by caspase-3". J. Biol. Chem. 273 (2): 1144–9. doi:10.1074/jbc.273.2.1144. PMID 9422780.
- Mühlhahn P, Zweckstetter M, Georgescu J, et al. (1998). "Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site". Nat. Struct. Biol. 5 (8): 682–6. doi:10.1038/1376. PMID 9699630.
- Chupp GL, Wright EA, Wu D, et al. (1998). "Tissue and T cell distribution of precursor and mature IL-16". J. Immunol. 161 (6): 3114–9. PMID 9743378.
- Bannert N, Avots A, Baier M, et al. (1999). "GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1541–6. doi:10.1073/pnas.96.4.1541. PMC 15509. PMID 9990060. //www.ncbi.nlm.nih.gov/pmc/articles/PMC15509/.
- Kim HS (1999). "Assignment of human interleukin 16 (IL16) to chromosome 15q26.3 by radiation hybrid mapping". Cytogenet. Cell Genet. 84 (1–2): 93. doi:10.1159/000015224. PMID 10343113.
- Liu Y, Cruikshank WW, O'Loughlin T, et al. (1999). "Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation". J. Biol. Chem. 274 (33): 23387–95. doi:10.1074/jbc.274.33.23387. PMID 10438516.
- Kaser A, Dunzendorfer S, Offner FA, et al. (1999). "A role for IL-16 in the cross-talk between dendritic cells and T cells". J. Immunol. 163 (6): 3232–8. PMID 10477592.
- Kurschner C, Yuzaki M (1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". J. Neurosci. 19 (18): 7770–80. PMID 10479680.
PDB gallery
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1i16: STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES
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1x6d: Solution structures of the PDZ domain of human Interleukin-16
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Cell signaling: cytokines
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- Elevated circulating levels of the pro-inflammatory cytokine macrophage migration inhibitory factor in individuals with acute spinal cord injury.
- Bank M1, Stein A2, Sison C3, Glazer A1, Jassal N2, McCarthy D2, Shatzer M2, Hahn B4, Chugh R5, Davies P5, Bloom O6.
- Archives of physical medicine and rehabilitation.Arch Phys Med Rehabil.2015 Apr;96(4):633-44. doi: 10.1016/j.apmr.2014.10.021. Epub 2014 Nov 15.
- OBJECTIVE: To test the hypothesis that macrophage migration inhibitory factor (MIF) is elevated in the circulation of individuals with acute spinal cord injury (SCI) compared with uninjured individuals.DESIGN: Prospective, observational pilot study.SETTING: Academic medical center.PARTICIPANTS: Adul
- PMID 25461821
- Emerging role of IL-16 in cytokine-mediated regulation of multiple sclerosis.
- Skundric DS1, Cruikshank WW2, Montgomery PC1, Lisak RP3, Tse HY4.
- Cytokine.Cytokine.2015 Feb 18. pii: S1043-4666(15)00009-5. doi: 10.1016/j.cyto.2015.01.005. [Epub ahead of print]
- Cytokines are pleiotropic soluble mediators of cellular functions. Cytokines are critical in immune pathogenesis of human diseases, including autoimmune CD4+ T cell mediated chronic inflammatory, demyelinating and neurodegenerative diseases of the central nervous system (CNS), multiple sclerosis (MS
- PMID 25703787
- Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca²⁺ and GTPγS.
- Balletta A1, Lorenz D2, Rummel A3, Gerhard R4, Bigalke H5, Wegner F6.
- Toxicology.Toxicology.2015 Feb 3;328:48-56. doi: 10.1016/j.tox.2014.12.006. Epub 2014 Dec 11.
- Clostridium difficile toxins A and B (TcdA and TcdB) belong to the class of large clostridial cytotoxins and inactivate by glucosylation some low molecular mass GTPases of the Rho-family (predominantly Rho, Rac and Cdc42), known as regulators of the actin cytoskeleton. TcdA and B also represent the
- PMID 25497110
Japanese Journal
- 血液疾患における免疫異常(<特集>医学研究のUP-to-DATE)
- 小池 道明
- 順天堂医学 51(1), 11-17, 2005-03-31
- … また,ビタミンD_3は以前より分化誘導物質として考えられており,各種悪性腫瘍に効果のあるアナログの検討がなされている.多発性骨髄腫の末梢血のCD4/CD8比が低下していることと,CD8^+T cellより産生され,CD4^+T cellを制御するIL-16を測定すると,病状が進行している症例で,高くなることが分かった.骨髄移植や分子標的療法の進歩が見られる中で,抗サイトカイン療法や,分化誘導療法も益々重要性が増してきていると考えられる. …
- NAID 110004616593
- Interleukin-16 in patients with alopecia areata
- TANYASIRI Kanlaya,HIRA Kayako,MITSUISHI Kouichi,UEKI Rie,SEKIGAWA Iwao,OGAWA Hideoki
- Journal of dermatological science 37(1), 55-57, 2005-01-01
- NAID 10018030437
Related Links
- The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product ...
- forum Join the Word of the Day Mailing List For webmasters TheFreeDictionary Google Bing? Word / Article Starts with Ends with Text ... in·ter·leu·kin-16 (in'tĕr-lū'kin), A cytokine made by T cells that is a potent chemotactant for CD4 + ...
Related Pictures
★リンクテーブル★
[★]
- 英
- interleukin-16、IL-16
- 関
- インターロイキン-16
[★]
- 関
- IL16、interleukin-16
[★]
- 英
- interleukin-16
- 関
- インターロイキン16
[★]
- 関
- IL-16 receptor
[★]
インターロイキン IL
[★]
インターロイキン IL