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English Journal

Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for osteoarthritis therapy.

Verma P1, Dalal K1, Chopra M2.
Journal of molecular modeling.J Mol Model.2016 Aug;22(8):178. doi: 10.1007/s00894-016-3035-8. Epub 2016 Jul 11.
In the development of osteoarthritis, aggrecan degrades prior to cartilage destruction. Aggrecanase-1 (ADAMTS-4) is considered to be the major enzyme responsible for cleaving the Glu373-Ala374 bond in the interglobular domain of aggrecan in humans. Therefore, inhibitors of ADAMTS-4 have therapeutic
PMID 27401455

Zweifler LE1, Ao M2, Yadav M3, Kuss P3, Narisawa S3, Kolli TN1, Wimer HF4, Farquharson C5, Somerman MJ2, Millán JL3, Foster BL6.
Journal of dental research.J Dent Res.2016 Jul;95(7):742-51. doi: 10.1177/0022034516640246. Epub 2016 Mar 25.
The tooth root and periodontal apparatus, including the acellular and cellular cementum, periodontal ligament (PDL), and alveolar bone, are critical for tooth function. Cementum and bone mineralization is regulated by factors including enzymes and extracellular matrix proteins that promote or inhibi
PMID 27016531

Reoxygenation enhances tumour necrosis factor alpha-induced degradation of the extracellular matrix produced by chondrogenic cells.

Markway BD1, Cho H, Anderson DE, Holden P, Ravi V, Little CB, Johnstone B.
European cells & materials.Eur Cell Mater.2016 Jun 24;31:425-39.
Mesenchymal stem cells (MSCs) have been considered as a potential source for cell-based therapies in arthritic diseases for both their chondrogenic and anti-inflammatory properties. Thus, we examined how MSC-based neocartilage responds to tumour necrosis factor alpha (TNF-α) compared to articular c
PMID 27341301

熊澤海道
小児歯科学雑誌 52(4), 480-486, 2014
乳幼児期に罹患した中耳炎の治療などに処方されるペニシリン系抗菌薬Amoxicillin によって，永久歯に色調異常や実質欠損を伴う形成不全が出現することが報告されている。しかし，本剤が歯の形成不全を引き起こすメカニズムについては未だ明らかでない。本研究は，ラットにAmoxicillin を投与した場合に，歯の形成に起こる変化について形態学的に検討した。その結果，Amoxicillin 投与群におい …
NAID 130005111637

Effect of Sulfur and Oxygen on Engulfment and Pushing of Deoxidation Particles of ZrO_2 and Al_2O_3 during Solidification of Fe-10mass%Ni Alloy

OHTA Hiroki,SUITO Hideaki
ISIJ international 46(4), 472-479, 2006-04-15
… particles are pushed to the interglobular region where the particle coagulation takes place with an increase in sulfur content. … particles are pushed to the interglobular region with an increase in oxygen content. …
NAID 10017618957

土谷昌広,笹野泰之,秋葉陽介,佐藤繁久,加賀山学,渡辺誠
日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society 46(108), 193, 2002-10-11
NAID 10010631194