WordNet

a substance (an atom or molecule or radical or ion) that forms a complex around a central atom

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Benton CB1, Ravandi F1.
Future oncology (London, England).Future Oncol.2017 Jan;13(2):125-133. Epub 2016 Sep 12.
Vosaroxin is a quinolone compound that intercalates DNA and induces TP53-independent apoptosis, demonstrating activity against acute myeloid leukemia (AML) in Phase I-III trials. Here, we examine vosaroxin's mechanism of action and pharmacology, and we review its use in AML to date, focusing on deta
PMID 27615555

Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.

Hu MH1, Chen SB1, Wang B1, Ou TM1, Gu LQ1, Tan JH2, Huang ZS3.
Nucleic acids research.Nucleic Acids Res.2016 Dec 6. pii: gkw1195. [Epub ahead of print]
Multiple G-quadruplex units in the 3'-terminal overhang of human telomeric DNA can associate and form multimeric structures. The specific targeting of such distinctive higher-order G-quadruplexes might be a promising strategy for developing selective anticancer agents with fewer side effects. Howeve
PMID 27923993

Almaqwashi AA1,2, Andersson J3,4, Lincoln P4, Rouzina I5, Westerlund F6, Williams MC1.
Scientific reports.Sci Rep.2016 Dec 5;6:37993. doi: 10.1038/srep37993.
The diverse properties of DNA intercalators, varying in affinity and kinetics over several orders of magnitude, provide a wide range of applications for DNA-ligand assemblies. Unconventional intercalation mechanisms may exhibit high affinity and slow kinetics, properties desired for potential therap
PMID 27917863

Discrimination of the Length of Double-stranded DNA Fragments by the Bis-intercalating Ligand (Proceedings of Asianalysis 4--The Fourth Asian Conference on Analytical Sciences)