UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

Agonist stimulation, talin-1, and kindlin-3 are crucial for α(IIb)β(3) activation in a human megakaryoblastic cell line, CMK.

Nakazawa T, Tadokoro S, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y.SourceDepartment of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Experimental hematology.Exp Hematol.2013 Jan;41(1):79-90.e1. doi: 10.1016/j.exphem.2012.09.011. Epub 2012 Sep 26.
Platelet integrin α(IIb)β(3) activation is regulated by inside-out signaling via agonist stimulation. However, when α(IIb)β(3) was exogenously expressed in cell lines such as Chinese hamster ovarian cells, physiological agonists hardly induced α(IIb)β(3) activation. To overcome this disadvanta
PMID 23022222

Distinct roles for the α, β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.

Alrehani N, Pradhan S, Khatlani T, Kailasam L, Vijayan KV.SourceK. Vinod Vijayan, PhD, Thrombosis Research, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USA, Tel.: +1 713 798 8677, Fax: +1 713 798 3415, E-mail: vvijayan@bcm.edu.
Thrombosis and haemostasis.Thromb Haemost.2012 Nov 29;109(1). [Epub ahead of print]
Although protein kinases and phosphatases participate in integrin αIIbβ3 signalling, whether integrin functions are regulated by the catalytic subunit of protein phosphatase 1 (PP1c) isoforms are unclear. We show that siRNA mediated knockdown of all PP1c isoforms (α, β and γ1) in 293 αIIbβ
PMID 23197154

Remorino A, Hochstrasser RM.SourceDepartment of Chemistry, University of Pennsylvania , Philadelphia Pa 19104.
Accounts of chemical research.Acc Chem Res.2012 Nov 20;45(11):1896-905. doi: 10.1021/ar3000025. Epub 2012 Mar 29.
The development of experiments that can generate molecular movies of changing chemical structures is a major challenge for physical chemistry. But to realize this dream, we not only need to significantly improve existing approaches but also must invent new technologies. Most of the known protein str
PMID 22458539